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Genetics (decision) PhD Projects, Programs & Scholarships

We have 47 Genetics (decision) PhD Projects, Programs & Scholarships

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  Markers of Expertise in Sport and Physical Activity: Triangulated Approaches
  Dr D Broadbent, Dr D Bishop, Dr A Cocks, Dr A Nowicky
Applications accepted all year round

Funding Type

PhD Type

The aim of this project is to adopt a mixed methods approach to determine the various factors – innate, learnt, and environmental – that ultimately contribute to skill acquisition and/or expertise within a specified domain.
  Scholarships available for SECReT: The International Training Centre for Security and Crime Related Research Degrees

Funding Type

PhD Type

SECReT. The International Training Centre for Security and Crime Related Research Degrees.
  Regulation of cell cycle progression in skeletal muscle stem cells
  Dr A G Borycki
Applications accepted all year round

Funding Type

PhD Type

The ability of skeletal muscles to regenerate in response to injury, exercise, growth or disease depends on a population of adult skeletal muscle stem cells called satellite cells.
  Integrated analysis of the Intra-tumour Heterogeneity of Oral squamous cell carcinoma
  Dr I Sequeira
Applications accepted all year round

Funding Type

PhD Type

Cancer is a heterogeneous disease with unique genomic and phenotypic features that differ between individual patients and among different regions within the same tumour.
  Regulation of gene expression in Drosophila ovarian germline stem cells
  Prof H Ashe, Prof M Ashe
Applications accepted all year round

Funding Type

PhD Type

Drosophila germline stem cells (GSCs) are a premier model for understanding stem cell regulation. Upon division, one GSC daughter remains a stem cell, whereas the other differentiates into a cystoblast (CB).
  Soma-Germline communication and the role of cortical polarity in signalling regulation during Drosophila spermatogenesis
  Dr F Papagiannouli
Application Deadline: 31 March 2020

Funding Type

PhD Type

Stem cells are critical for multi-cellular development, since they supply the cells that build up our bodies and replenish, as we age, worn out, damaged, and diseased tissues.
  EPSRC Centre for Doctoral Training in Sustainable Approaches to Biomedical Science: Responsible and Reproducible Research - SABS

Funding Type

PhD Type

Good degree in the Physical or Life Sciences? Interested in biological or medical research? We offer fully-funded PhD places across the Oxford Doctoral Training Centre programmes.
  Normal and malignant blood stem cell biology
  Dr D G Kent, Prof I Hitchcock
Application Deadline: 30 June 2020

Funding Type

PhD Type

One of the simplest and most provocative concepts in all of stem cell biology is how a single stem cell can give rise to any of the highly specialised cell types of a given tissue while also having the capacity to make a new equally potent stem cell.
  Biodiversity conservation ex situ or in situ with a focus on genetic diversity.
  Dr N Maxted
Applications accepted all year round

Funding Type

PhD Type

Field studies, ecogeography, geographic information systems and estimation of patterns of genetic diversity, IUCN taxonomic and genetic threat assessment will help elucidate conservation strategies and taxonomic clarity of critically endanged plant species.
  Build and destroy: investigating targeted protein degradation in plant development and stress-response
  Dr D Gibbs
Applications accepted all year round

Funding Type

PhD Type

In order to effectively co-ordinate their growth and development, plants need to be able to respond to changes in their environment, whether it is adapting to the seasons or coping with stresses.
  Determining novel molecular regulators of necrosis controlling premature cell death
  Dr Y Fan
Applications accepted all year round

Funding Type

PhD Type

Necrosis, a form of premature cell death, is frequently caused by excessive insults such as trauma, infection and toxins. It has been implicated in many human diseases including cancer, neurodegenerative disorders and inflammatory diseases.
  Discovering molecular genetic mechanisms of central nervous system regeneration
  Dr A Hidalgo
Applications accepted all year round

Funding Type

PhD Type

Is it possible to promote regeneration of the central nervous system after injury, damage or disease? During normal development, neutrons and glia interact to coordinate the generations of neutrons and glia, and direct cell migration patterns, axonal navigation, dendritic arborisation and the emergence of neural circuits.
  Genetic analysis of the bacterial translocation machinery
  Dr D Huber
Applications accepted all year round

Funding Type

PhD Type

Every subcellular compartment in a cell contains proteins, and yet all of these proteins are initially synthesised in the same compartment.
  Identifying the evolutionary origins of the MADS-box floral quartet mechanism in seedless vascular plants
  Dr A.R.G Plackett, Dr J C Coates
Application Deadline: 31 March 2020

Funding Type

PhD Type

Despite its commonplace occurrence in today’s environment, the reproduction of plants via flowers and seeds is a recent evolutionary innovation arising from an ancestral seedless reproductive system similar to that still found in a subset of today’s plants (e.g.
  Investigating the influence of polyploidy on the evolution of a major human fungal pathogen
  Dr E Ballou
Applications accepted all year round

Funding Type

PhD Type

The human fungal pathogen Cryptococcus neoformans undergoes an unusual morphological transition from haploid yeast to highly polyploid Titan cells during infection of the human host.
  Molecular and genetic mechanisms of brain structural plasticity and neurodegeneration in the fruit-fly Drosophila.
  Dr A Hidalgo
Applications accepted all year round

Funding Type

PhD Type

The brain changes throughout life. brain plasticity enables the brain to adjust in response to experience, whereas during aging natural neurodegeneration takes over.
  Regulation of apoptosis-induced compensatory cell proliferation and its implications for cancer and tissue regeneration
  Dr Y Fan
Applications accepted all year round

Funding Type

PhD Type

In multi-cellular organisms, coordinated cell death (e.g. apoptosis) and cell replacement is critical for tissue recovery in response to stress or damage.
  Understanding signalling networks underpinning key developmental processes during plant evolution
  Research Group: BBSRC MIBTP
  Dr J C Coates
Applications accepted all year round

Funding Type

PhD Type

Plants first appeared on land almost half a billion years ago. All land plants likely evolved from a single aquatic green algal ancestor.
  A multiple modality approach for targeting treatment-resistant ovarian cancer
  Dr E. Sanij, Prof R. Pearson
Applications accepted all year round

Funding Type

PhD Type

High-grade serous ovarian cancer (HGSOC) accounts for 70% of ovarian cancer (OvCa) deaths and its five-year survival rate is 43%.
  Analytic methods for detecting and making sense of somatic genomic rearrangements
  Prof A Papenfuss
Applications accepted all year round

Funding Type

PhD Type

Bioinformatics is the application of mathematics, statistics and computational methods to the analysis of molecular biology data.
  Cellular cross-talk at the perivascular niche and the blood brain barrier
  Prof B Hogan
Applications accepted all year round

Funding Type

PhD Type

Much research on vasculature has focussed on the endothelial cells that line functional vessels, however the milieu of cells that surround vessels (mural cells) play important and under-appreciated roles in homeostasis and disease.
  Clinical cancer bioinformatics: developing new bioinformatics methods for improved analysis of cancer gene hybridisation capture panels
  Prof A Papenfuss
Applications accepted all year round

Funding Type

PhD Type

Bioinformatics is the application of mathematics, statistics and computational methods to the analysis of molecular biology data.
  Computational simulation of tumour formation and progression
  Dr D. Goode
Applications accepted all year round

Funding Type

PhD Type

Tumours comprise a complex mix of related but distinct cellular subpopulations that both compete and complement one another. These dynamics strongly influence how and when a tumour forms as well as its response to therapy, however there are hard to observe directly.
  Genomic determinants of long-term survival in ovarian cancer
  Research Group: Cancer Genetics & Genomics Laboratory
  Prof D. Bowtell, Dr D Garsed
Applications accepted all year round

Funding Type

PhD Type

High-grade serous ovarian cancer is an aggressive disease in which only ~30% of women survive 5 years or more. Despite a poor prognosis, a subset of patients are highly responsive to chemotherapy, and some become long-term survivors (>10 years survival).
  How does amino acid metabolism affect tumour growth?
  Dr L. Cheng
Applications accepted all year round

Funding Type

PhD Type

The effect of diet on tumour growth is hotly debated but poorly characterized. Due to the heterogeneous nature of the tumours, dietary studies in patients with varied genetic background often led to inconclusive outcome.
  Inhibition of PRMT5 as a cancer therapy
  Dr K. Sheppard
Applications accepted all year round

Funding Type

PhD Type

Targeted therapy has had profound impact on outcomes for cancer patients.
  mRNA translation reprogramming and metabolic re-wiring in response to ribosome-targeted therapies
  Prof R. Pearson, Dr J Kang
Applications accepted all year round

Funding Type

PhD Type

Increased synthesis and activity of ribosomes are associated with oncogenesis downstream of the major oncogenes including MYC, RAS and PI3K.
  RNA Methylation in normal and malignant blood development
  Dr L. Kats
Applications accepted all year round

Funding Type

PhD Type

As is the case with DNA and histones, RNA can also be modified and indeed more than 100 chemical groups that decorate all four canonical RNA nucleotides have been described.
  Role of the tumour microenvironment in gastric cancer
  Dr A. Boussioutas, Dr R. Busuttil
Applications accepted all year round

Funding Type

PhD Type

Gastric cancer (GC) is the fourth most common cancer globally and 7th in incidence in Australia. It has a poor survival rate which can be attributed to the advanced stage at diagnosis in most patients.
  Targeting IDH mutations in acute myeloid leukaemia
  Dr L. Kats
Applications accepted all year round

Funding Type

PhD Type

Acute Myeloid Leukaemia (AML) is an aggressive disease with poor prognosis and development of novel treatment options is urgently needed.
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