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Genetics (php) PhD Projects, Programs & Scholarships

We have 15 Genetics (php) PhD Projects, Programs & Scholarships

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  How protective signals from the gut modify neuronal activity and behaviour, using C. elegans as a model system.
  Research Group: Astbury Centre for Structural Molecular Biology
  Dr P van Oosten-Hawle, Prof N Cohen
Applications accepted all year round

Funding Type

PhD Type

Amyloid protein misfolding leading to loss of neuronal function are fundamental pathogenic mechanisms of numerous age-associated neurodegenerative diseases, including Alzheimer’s (AD).
  Machine learning approaches for the clinical diagnosis of autoimmune disease
  Dr A Auer-Fowler, Dr P Green
Application Deadline: 12 April 2020

Funding Type

PhD Type

Autoimmune diseases have a range of complex symptoms and are therefore typically hard to diagnose. Current diagnostic methods are often invasive, painful, and subjective.
  Is breast cancer more aggressive when developed by rural-dwellers compared to those living in the city?
  Prof P Murchie, Prof Z Miedzybrodzka, Prof V Speirs, Dr R Vieira
Application Deadline: 29 May 2020

Funding Type

PhD Type

BACKGROUND.
  PhD Student - Functional Analysis of UHRF1 (f/m/d)
  Dr T Bartke
Applications accepted all year round

Funding Type

PhD Type

As German Research Center for Environmental Health, Helmholtz Zentrum München pursues the goal of developing personalized medical approaches for the prevention and therapy of major common diseases such as diabetes mellitus, allergies and lung diseases.
  Investigate a novel, unexplored link between WNT signalling and regulators of cell migration in cancer progression using CRISPR-Cas9 and advanced live cell imaging.
  Dr M Krause
Applications accepted all year round

Funding Type

PhD Type

Cancer is a devastating disease. more than one in three people in the UK will develop cancer in their lifetime. WNT signalling is a key pathway controlling morphogenesis in embryos and it has been shown that perturbations of this pathway promote cancer progression.
  Investigation of a probiotic strain of Lactobacillus plantarum 2025 and the development of novel antibacterials
  Prof A Karlyshev
Applications accepted all year round

Funding Type

PhD Type

Background. The rise of multidrug resistant forms of microbial pathogens imposes a serious problem to public health worldwide. The rapid spread of antimicrobial resistance is associated with misuse of conventional antibiotics.
  Interneuron Development in the Zebrafish Spinal Cord
  Dr K Lewis
Applications accepted all year round

Funding Type

PhD Type

The Lewis Lab moved to Syracuse University from Cambridge University in the UK in 2010.
  Precision Medicine DTP – Development of clinically relevant models of undifferentiated pleomorphic sarcoma using a genetic screening approach
  Research Group: Edinburgh Cancer Research Centre
  Prof V Brunton, Dr L Boulter, Dr M Taylor, Prof D M Salter
Application Deadline: 6 April 2020

Funding Type

PhD Type

Background. Sarcomas are relatively uncommon cancers thought to arise from pluripotent mesenchymal stem cells. Undifferentiated pleomorphic soft tissue sarcoma (UPS), though one of the commonest sarcoma subtypes encountered, exemplify the limitations of historical progress in sarcoma therapy.
  Precision Medicine DTP - Dissecting the biophysics of ocular transcription factors in vivo
  Research Group: MRC Human Genetics Unit
  Dr D Papadopoulos, Prof W Bickmore, Prof V Vukojevic
Application Deadline: 6 April 2020

Funding Type

PhD Type

Background. Of the ~1,600 human TF genes, up to ~25% (~400 genes) are expected to be haploinsufficient with a plethora of them leading to developmental disorders1, underlining that transcription factor (TF) abundance (dosage) plays a major role during cell and tissue specification.
  Precision Medicine DTP - Illuminating roles of Wnt/b-Catenin signalling in nonalcoholic fatty liver disease (NAFLD)
  Research Group: MRC Centre for Regenerative Medicine
  Dr K Kaji, Dr S Tomlinson, Prof J Fallowfield
Application Deadline: 6 April 2020

Funding Type

PhD Type

Background. Non-Alcoholic Fatty Liver Disease (NAFLD) caused by a high fat diet (HFD) is a growing major public health problem world-wide.
  Precision Medicine DTP – Integration of single-cell RNA sequencing data from human and murine kidney disease to identify novel therapeutic targets
  Dr BC Conway, Dr T Chandra, Dr D Ferenbach
Application Deadline: 6 April 2020

Funding Type

PhD Type

Background. Chronic kidney disease (CKD) is a major risk factor for cardiovascular disease and for end-stage kidney disease (ESRD), at which point patients require dialysis or transplantation.
  Precision Medicine DTP – Investigating the metabolic alterations that initiate pre-neoplastic development in zebrafish and in humans
  Research Group: Centre for Inflammation Research
  Dr Y Feng, Dr K Burgess, Dr R Burchmore, Dr G Ho
Application Deadline: 6 April 2020

Funding Type

PhD Type

Background. “Warburg metabolism” is characterised by an increased uptake of glucose and its conversion to lactate by glycolysis under normoxia.
  Precision Medicine DTP - Leveraging protein quantitative trait loci to discover new biology and therapeutic targets
  Prof J Wilson, Dr P Navarro, Dr L Klaric
Application Deadline: 6 April 2020

Funding Type

PhD Type

Proteins are attractive drug targets, however, a prerequisite for successful drug development is efficacy, which is predicated on the drug target playing a causal role in disease1.
  Precision Medicine DTP - Taming the Hippo in Cancer through Proteogenomics
  Research Group: Centre for Inflammation Research
  Dr C G Hansen, Prof J Lehtio
Application Deadline: 6 April 2020

Funding Type

PhD Type

Background. Pleural Mesothelioma is an asbestos-related cancer, and is one of the deadliest cancer types. Current methods of treatment and early diagnostics are ineffective.
  Precision Medicine DTP – Using Omics to Understand the Genes and Pathways Underlying Alcohol Use Disorder
  Research Group: Centre of Genomic and Experimental Medicine
  Dr K Evans, Dr T-K Clarke, Dr S Glerup
Application Deadline: 6 April 2020

Funding Type

PhD Type

Background. Alcohol misuse is a huge public health problem, and those who attempt to curtail consumption can be hampered by highly aversive withdrawal symptoms.
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