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Genetics (science communication) PhD Projects, Programs & Scholarships

We have 72 Genetics (science communication) PhD Projects, Programs & Scholarships

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  MRC DiMeN Doctoral Training Partnership: Are microbes the hidden influencers? Unravelling the genomic network of host-microbe interactions
  Dr D Rico, Prof S Hambleton, Dr C Lamb, Prof R Hirt
Application Deadline: 6 January 2020

Funding Type

PhD Type

Background and hypotheses. Each of us has a genome. The genome is the same in every cell of our organism but its three-dimensional (3D) structure is different in every cell type.
  MRC DiMeN Doctoral Training Partnership: RNA modifications: cracking the RNA code in health and disease
  Prof K Stellos, Prof I Spyridopoulos, Dr A Gatsiou, Dr S Tual-Chalot
Application Deadline: 6 January 2020

Funding Type

PhD Type

Inflammation comprises a fundamental biological process tasked to protect our body against invasion of microorganisms (e.g virus, bacteria, etc).
  MRC DiMeN Doctoral Training Partnership: Metadata Integration in Biological Networks to Identify New Therapeutic Targets in Giant Cell Arteritis
  Dr L Cutillo, Prof A Morgan
Application Deadline: 6 January 2020

Funding Type

PhD Type

This PhD’s primary focus is to use genotypic data to elucidate the pathogenesis of giant cell arteritis (GCA) and related clinical phenotypes to identify new treatment targets.
  MRC DiMeN Doctoral Training Partnership: How do non-coding enhancer RNAs confer genetic risk in Amyotrophic Lateral Sclerosis (ALS)?
  Dr Dan Bose, Dr J Cooper-Knock
Application Deadline: 6 January 2020

Funding Type

PhD Type

Project. Amyotrophic Lateral Sclerosis (ALS) is an aggressive neurodegenerative disease with no effective therapy. The established genetic causes of ALS can only explain a small fraction of the observed disease phenotypes.
  MRC DiMeN Doctoral Training Partnership: Building integrated machine learning and genomic approaches to quantitate bone quality and fracture risk
  Prof M Wilkinson, Prof A Frangi, Prof E Zeggini
Application Deadline: 6 January 2020

Funding Type

PhD Type

Is this project for you?. This PhD Project would suit a student inspired by the prospect of participating in a truly multidisciplinary team.
  MRC DiMeN Doctoral Training Partnership: How do non-coding enhancer RNAs confer genetic risk in Amyotrophic Lateral Sclerosis (ALS)?
  Dr Dan Bose, Dr J Cooper-Knock
Application Deadline: 6 January 2020

Funding Type

PhD Type

Project. Amyotrophic Lateral Sclerosis (ALS) is an aggressive neurodegenerative disease with no effective therapy. The established genetic causes of ALS can only explain a small fraction of the observed disease phenotypes.
  MRC DiMeN Doctoral Training Partnership: Investigating the in vivo targets and mechanism of action of a toxic acetylcholinesterase-derived peptide upregulated in Alzheimer’s disease
  Dr M Collins, Prof S Greenfield
Application Deadline: 6 January 2020

Funding Type

PhD Type

Alzheimer’s disease (AD) is a progressive neurodegenerative disease that is characterised by the deposition and accumulation of amyloid beta plaques and phosphorylated tau filaments in the brain, the latter correlating with the onset of symptoms.
  MRC DiMeN Doctoral Training Partnership: Targeting ageing mitochondrial metabolism with dietary interventions to combat colorectal cancer
  Dr M J P Simons, Dr K Campbell, Dr L Greaves
Application Deadline: 6 January 2020

Funding Type

PhD Type

Background. Colorectal cancer is the second most common cause of death by cancer in the UK. Diet in particular, impacts on colorectal cancer development.
  Artificial skyglow impacts on the chronobiology of marine organisms
  Dr A Ellison, Dr S Jenkins
Application Deadline: 17 January 2020

Funding Type

PhD Type

The ecological impact of artificial light at night has been a rapidly growing field of global change science in recent years.
  MRC DiMeN Doctoral Training Partnership: A New Front in Microbial Warfare—Delivery of Antifungal Effectors by the Type VI Secretion System
  Prof J Quinn, Dr C Stewart
Application Deadline: 6 January 2020

Funding Type

PhD Type

The type VI secretion system (T6SS) is widely used by bacteria to fire diverse effector proteins directly into neighbouring target cells.
  MRC DiMeN Doctoral Training Partnership: Interbacterial competition during Mycobacterium abscessus colonisation of the lung in people with cystic fibrosis
  Dr T Palmer, Dr M Brodlie
Application Deadline: 6 January 2020

Funding Type

PhD Type

Cystic fibrosis (CF) is the most common life-limiting genetic disorder in the UK. Respiratory infection is responsible for the majority of morbidity and mortality.
  MRC DiMeN Doctoral Training Partnership: Investigating the mechanisms leading to CHK1 inhibitor resistance in cancer therapy
  Prof N Perkins, Prof S Rocha, Dr J Hunter
Application Deadline: 6 January 2020

Funding Type

PhD Type

DNA replication stress results from stalled DNA replication forks and is a feature of cancer cells, where it can lead to the genomic instability driving tumorigenesis.
  MRC DiMeN Doctoral Training Partnership: Mitochondrial DNA mutations in blood: Why do they decline?
  Dr S Pickett, Prof M Collins, Dr O Russell
Application Deadline: 6 January 2020

Funding Type

PhD Type

Mitochondrial diseases are caused by mutations in nuclear and mitochondrial (mt) genomes and there is currently no cure for these debilitating disorders.
  MRC DiMeN Doctoral Training Partnership: The role of circular RNAs in the development and progression of Parkinson’s disease
  Dr M Jackson, Dr M Santibanez-Koref, Dr G Hudson, Dr O Izuogy
Application Deadline: 6 January 2020

Funding Type

PhD Type

In the UK alone there are currently 145,000 people diagnosed with Parkinson’s disease (PD). In an increasingly aged population, this number is rising, with on average 2 people every hour told that they have PD.
  MRC DiMeN Doctoral Training Partnership: Towards specialised treatments for childhood-onset neurological diseases
  Dr C Schneider, Prof R Horvath
Application Deadline: 6 January 2020

Funding Type

PhD Type

Neurodegeneration is a feature of many debilitating, incurable diseases with underlying defects in RNA metabolism (e.g. spinal muscular atrophy, ALS), but the link between RNA biology and neuronal death is poorly understood.
  Conservation genomic management for endangered species breeding programmes
  Dr R Ogden, Dr G Gorjanc, Prof J Hickey, Dr E Humble
Application Deadline: 9 January 2020

Funding Type

PhD Type

Background. Ex-situ management, including captive breeding, plays a vital role in the conservation of endangered and threatened species (McGowan et al., 2017).
  MRC DiMeN Doctoral Training Partnership: Developing microfluidic devices for cellular modelling of inherited eye diseases
  Prof C A Johnson, Prof C Wälti
Application Deadline: 6 January 2020

Funding Type

PhD Type

Inherited retinal dystrophies are a leading cause of blindness and visual loss. Over 20,000 individuals in the UK are registered blind or partially sighted because of these conditions, caused by mutations in over 260 genes.
  MRC DiMeN Doctoral Training Partnership: Dissecting the function of long non-coding RNAs during neuronal differentiation and neuronal diseases
  Dr J Aspden, Dr G Hautbergue, Dr J Fontana
Application Deadline: 6 January 2020

Funding Type

PhD Type

Whilst 85% of our genome is transcribed, only 4% is protein-coding. In fact, many non-coding RNAs exist, some of which are similarly processed to mRNAs, termed long non-coding RNAs (lncRNAs).
  MRC DiMeN Doctoral Training Partnership: From atoms to organoids: understanding how abnormal cilia cause a neurodevelopmental disorder
  Dr T Ochi, Prof CA Johnson
Application Deadline: 6 January 2020

Funding Type

PhD Type

Eukaryotic primary cilia are the “antennae” of eukaryotic cells that detect and integrate a wide variety of environmental signals essential for photosensation in the eyes, chemosensation in the nose, and mechanosensation in the kidneys.
  MRC DiMeN Doctoral Training Partnership: Individualised heteroclitic peptide immunotherapies for hepatocellular carcinoma
  Dr A Samson, Dr R Tooze
Application Deadline: 6 January 2020

Funding Type

PhD Type

Background. Hepatocellular carcinoma (HCC) is a cancer of unmet need, with 12% five-year survival across all stages, due to late diagnosis and inadequate non-personalised therapies.
  MRC DiMeN Doctoral Training Partnership: Understanding proteotoxicity of alpha- and gamma-synuclein in neuronal C. elegans models of neurodegeneration
  Dr P van Oosten-Hawle, Prof S E Radford
Application Deadline: 6 January 2020

Funding Type

PhD Type

Synucleopathies, such as Parkinson’s Disease (PD), are neurodegenerative diseases characterised by the accumulation of alpha-synuclein (asyn) aggregates into Lewy Bodies in neurons, leading to toxicity and cell death.
  MRC DiMeN Doctoral Training Partnership: A single nucleotide polymorphism (SNP) predisposes people to cardiovascular and musculoskeletal disease: an investigation into altered collagen networks using MSCs, tissue engineering and lncRNA analysis
  Dr EG Laird, Dr JR Henstock, Dr D Young, Prof K Stellos
Application Deadline: 6 January 2020

Funding Type

PhD Type

IMPORTANCE. A single nucleotide polymorphism (SNP) present in one quarter of the population (rs1800012) is associated with osteoporotic fracture, intervertebral disc degeneration and cardiovascular disease.
  MRC DiMeN Doctoral Training Partnership: Functional and genetic analyses of HSPB mutations underlying progressive neuronal deficits in Charcot-Marie-Tooth disease
  Dr J Barclay, Dr E Seward, Dr D Hammond
Application Deadline: 6 January 2020

Funding Type

PhD Type

Understanding the cellular and molecular mechanisms underlying progressive neurological deterioration is a key challenge in modern biomedical research.
  MRC DiMeN Doctoral Training Partnership: Machine learning approaches for the analysis of circulating tumour DNA
  Dr A Auer-Fowler, Dr A Jorgensen, Dr J Cook
Application Deadline: 6 January 2020

Funding Type

PhD Type

Tumour cells arise from genetic variants (usually mutations) in cells, which lead to unrestrained cell division.
  MRC DiMeN Doctoral Training Partnership: Development of an automated analysis pipeline to study bacterial cell wall structure and resistance to beta-lactam antibiotics
  Dr S Mesnage, Dr M Collins
Application Deadline: 6 January 2020

Funding Type

PhD Type

The most widely used antibiotics ever discovered (beta-lactams) are targeting the enzymes that polymerize peptidoglycan (PG), the essential component of the bacterial cell wall.
  MRC DiMeN Doctoral Training Partnership: How does the human innate immune system kill the Streptococcus pneumoniae bacterium during infection?
  Dr A Fenton, Dr L Prince
Application Deadline: 6 January 2020

Funding Type

PhD Type

Background. The bacterium Streptococcus pneumoniae is a highly successful human pathogen and a leading cause of pneumonia, a disease responsible for millions of deaths every year.
  MRC DiMeN Doctoral Training Partnership: How to kill a difficult superbug: understanding the evolution of antimicrobial resistance in Clostridioides difficile
  Dr R Fagan, Prof M Brockhurst
Application Deadline: 6 January 2020

Funding Type

PhD Type

Increasing resistance to antibiotics is one of the greatest health challenges facing humanity today. Clostridioides difficile is the primary cause of antibiotic-associated infections in UK hospitals and antibiotic-induced disruption of the gut microbiota is a prerequisite for infection.
  MRC DiMeN Doctoral Training Partnership: Activation of Aurora Kinase A by DNA damage – understanding the signalling pathway to improve radiotherapy response
  Dr H Bryant, Prof C Eyers, Prof P Eyers
Application Deadline: 6 January 2020

Funding Type

PhD Type

Radiation is a mainstay of cancer therapy, however radioresistance is a significant challenge in the treatment of locally advanced, recurrent and metastatic cancers.
  MRC DiMeN Doctoral Training Partnership: Development of an automated analysis pipeline to study bacterial cell wall structure and resistance to beta-lactam antibiotics
  Dr S Mesnage, Dr M Collins
Application Deadline: 6 January 2020

Funding Type

PhD Type

The most widely used antibiotics ever discovered (beta-lactams) are targeting the enzymes that polymerize peptidoglycan (PG), the essential component of the bacterial cell wall.
  MRC DiMeN Doctoral Training Partnership: How does the human innate immune system kill the Streptococcus pneumoniae bacterium during infection?
  Dr A Fenton, Dr L Prince
Application Deadline: 6 January 2020

Funding Type

PhD Type

Background. The bacterium Streptococcus pneumoniae is a highly successful human pathogen and a leading cause of pneumonia, a disease responsible for millions of deaths every year.
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