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Genetics (transcription) PhD Projects, Programs & Scholarships

We have 70 Genetics (transcription) PhD Projects, Programs & Scholarships

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  Post-translational regulation of transcription dynamics in plant immunity
  Research Group: Institute of Molecular Plant Sciences
  Dr S Spoel, Dr E Bayne
Application Deadline: 5 January 2020

Funding Type

PhD Type

Precise regulation of gene transcription is vital for all organisms. In eukaryotes, dynamic changes in gene transcription orchestrate cell development and cellular responses to the ever changing environment.
  Biochemical analysis of the interaction of pluripotency transcription factors with RNA polymerase enzymes
  Research Group: Institute of Stem Cell Research
  Prof I Chambers
Application Deadline: 5 January 2020

Funding Type

PhD Type

Pluripotent stem cells possess the dual defining properties of self-renewal and multi-lineage differentiation potential. To retain an effective differentiation capacity, self-renewal must occur at high efficiency.
  Stopping transcription at the end of mammalian protein coding genes: How is this achieved and why does this matter
  Prof N J Proudfoot
Application Deadline: 10 January 2020

Funding Type

PhD Type

This research project will focus on my lab’s recent development of genomic methodology for nascent transcription analysis (1).
  Selective control of tRNA gene transcription by steroid receptors and BRCA1.
  Prof R J White, Dr W Brackenbury
Application Deadline: 5 January 2020

Funding Type

PhD Type

BRCA1 is an important tumour suppressor protein with roles in DNA repair. and transcription. BRCA1 binds many tRNA genes, but its role there is.
  Epigenetic regulation of meiotic genes by the transcription factor Hac1i
  Dr M Schroeder
Applications accepted all year round

Funding Type

PhD Type

A self-funded PhD studentship to investigate how the transcription factor Hac1i achieves epigenetic regulation of early meiotic genes is available in the group of Dr.
  Transcription factors mediating light input to the Arabidopsis circadian clock
  Dr P Devlin
Applications accepted all year round

Funding Type

PhD Type

The circadian clock is tightly tied to the light environment. Transcriptional feedback loops are able to generate a self-sustaining rhythm of approximately 24 hours which impinges on almost every aspect of physiology in higher organisms.
  Effects of transcription on genome stability
  Prof N J Savery
Applications accepted all year round

Funding Type

PhD Type

Transcription-coupled DNA repair (TCR) pathways prioritise the repair of certain lesions in "active" genes. These pathways help maintain genome integrity throughout the lifetime of multi-cellular organisms, and thus help prevent the occurrence of mutation that might cause cancer or other disorders.
  Precision Medicine DTP - Dissecting the biophysics of ocular transcription factors in vivo
  Research Group: MRC Human Genetics Unit
  Dr D Papadopoulos, Prof W Bickmore, Prof V Vukojevic
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. Of the ~1,600 human TF genes, up to ~25% (~400 genes) are expected to be haploinsufficient with a plethora of them leading to developmental disorders1, underlining that transcription factor (TF) abundance (dosage) plays a major role during cell and tissue specification.
  The role of cyclin-dependent kinases (CDKs) in transcription and cell cycle control.
  Prof C Norbury, Prof S Murphy
Application Deadline: 10 January 2020

Funding Type

PhD Type

Cyclin-dependent kinases (CDKs), including CDK1, 2, 4 and 6, act as master regulators of the cell cycle through phosphorylation of numerous protein targets (1).
  Replication and transcription machinery collisions in Escherichia coli.
  Dr M Hawkins, Prof M Leake
Application Deadline: 5 January 2020

Funding Type

PhD Type

DNA duplication is essential for life but replication forks can be blocked when. they collide with proteins bound to DNA. Exactly how multiple rescue.
  Transcription control and immune evasion in African trypanosomes
  Research Group: Division of Cell & Molecular Biology
  Prof G Rudenko
Applications accepted all year round

Funding Type

PhD Type

Trypanosomes are unicellular eukaryotes which cause African Sleeping Sickness, which is endemic to subSaharan Africa. Trypanosomes can be easily grown as suspension cell lines in the laboratory, where they are straightforward to manipulate and genetically modify.
  Kinase regulation of HOX transcription factors – a potential target in cancer?
  Research Group: Institute of Cancer Therapeutics
  Prof R Morgan, Dr S Shnyder
Applications accepted all year round

Funding Type

PhD Type

The HOX genes are a family of transcription factors that have a number of important functions in cancer, including cell survival and metastasis.
  An ancient transcription factor controlling cuticle development and water transport in the liverwort Marchantia polymorpha
  Research Group: Institute of Molecular Plant Sciences
  Dr W J Goodrich, Dr C Kidner
Application Deadline: 5 January 2020

Funding Type

PhD Type

We identified a basic helix loop helix transcription factor (called ZOU) which is specifically expressed in the endosperm of seed in flowering plants.
  EASTBIO An ancient transcription factor controlling cuticle development and water transport in the liverwort Marchantia polymorpha
  Research Group: Institute of Molecular Plant Sciences
  Dr W J Goodrich, Dr C A Kidner
Application Deadline: 5 January 2020

Funding Type

PhD Type

We identified a basic helix loop helix transcription factor (called ZOU) which is specifically expressed in the endosperm of seed in flowering plants.
  The impact of mixed radiation and chemicals exposure on neuronal cytotoxicity, ageing and transcription
  Dr R Anderson
Application Deadline: 6 January 2020

Funding Type

PhD Type

A 3-year funded PhD studentship is available in the College of Health and Life Sciences at Brunel University London. Project description.
  New ways of terminating transcription in bacterial pathogens
  Dr C Brown
Applications accepted all year round

Funding Type

PhD Type

An excellent PhD candidate (’A’ grades) interested in researching the fundamental process of gene expression in bacteria is being recruited to join a multidisciplinary team led at University of Otago, Dunedin, New Zealand.
  BBSRC MIBTP: Transcriptional regulators of gene expression in human cells
  Dr P Grzechnik, Dr S Brogna
Application Deadline: 12 January 2020

Funding Type

PhD Type

Position for a PhD student is available in the group of Dr Pawel Grzechnik at the University of Birmingham. The aim of the project is to uncover novel roles for transcriptional factors and to investigate how mRNA processing alters gene expression in human cells.
  Understanding the role that the RNA helicase UPF1 plays in sorting ribonucleoprotein (RNP) complexes and the mechanism by which this role of UPF1 might reduce cellular stress and cell degeneration.
  Dr S Brogna
Application Deadline: 7 January 2020

Funding Type

PhD Type

This project’s specific objective is to study the molecular role(s) that the RNA helicase UPF1 plays in RNA processing. UPF1 is a key player in nonsense-mediated mRNA decay (NMD), it is universally conserved in eukaryotes and is essential to the development of many organisms [1].
  Hypoxia links the unfolded proteim response with the DNA damage response
  Prof E Hammond, Prof A Giaccia
Application Deadline: 10 January 2020

Funding Type

PhD Type

THE PROJECT. Regions of hypoxia (insufficient oxygen) occur in most if not all solid tumours and are clinically relevant as they correlate with poor patient prognosis and therapy resistance.
  Functions of cyclin-dependent kinase 11 (CDK11) in regulation of gene expression
  Dr D Blažek, Assoc Prof Z Zdráhal, Dr P Alexiou
Application Deadline: 18 December 2019

Funding Type

PhD Type

CDK11 is ubiquitously expressed in all tissues and the CDK11 null mouse is lethal at an early stage of development indicating an important role for Cdk11 in the adult as well as during development.
  Using statistical and functional analysis to investigate the contrasting disease specific roles of IL6R and the chr17q12 locus in the development of rheumatoid arthritis and asthma
  Dr J Curtin, Prof A Simpson
Applications accepted all year round

Funding Type

PhD Type

The Arthritis Research UK and Respiratory Centres at the University of Manchester have extensive research programmes investigating the genetic components of rheumatoid arthritis (RA) and asthma.
  Using synthetic biology to understand the evolution of antibiotic resistance
  Dr M Lagator, Dr C Knight
Applications accepted all year round

Funding Type

PhD Type

Imagine an architect, tasked with converting an old stadium into a building with a different function, without demolishing it.
  Protein glycosylation as a novel biomarker for bile duct cancer and other liver diseases
  Dr P-S Jayaraman
Application Deadline: 12 January 2020

Funding Type

PhD Type

Protein modifications are important in many diseases including fibrosis and cancer. In protein glycosylation carbohydrate polymers, or glycans, are covalently attached to proteins forming glycoproteins.
  Build and destroy: investigating targeted protein degradation in plant development and stress-response
  Dr D Gibbs
Applications accepted all year round

Funding Type

PhD Type

In order to effectively co-ordinate their growth and development, plants need to be able to respond to changes in their environment, whether it is adapting to the seasons or coping with stresses.
  RNA metabolism in response to cellular stress
  Dr P Grzechnik, Dr S Brogna
Application Deadline: 31 January 2020

Funding Type

PhD Type

The aim of the project is to understand roles for mRNA processing during the stress response in eukaryotic cells. Exposure to acute stress reduces cell viability or fitness and therefore immediate adaption is crucial for cell survival.
  EASTBIO A quantitative approach to understanding regulation of developmental genes by bivalent promoters
  Research Group: Institute of Cell Biology
  Dr P Voigt, Dr G Sanguinetti
Application Deadline: 5 January 2020

Funding Type

PhD Type

Histone modifications play key roles in the regulation of gene expression. In embryonic stem cells, promoters of developmental genes carry a signature combination of histone H3 lysine 4 trimethylation (H3K4me3), which is usually found at active promoters, and H3K27me3, a hallmark of repressive chromatin.
  EASTBIO Defining the structural basis of Tdp1-dependent DNA repair
  Research Group: Institute of Quantitative Biology, Biochemistry and Biotechnology
  Dr J Richardson, Dr H Interthal
Application Deadline: 5 January 2020

Funding Type

PhD Type

DNA topoisomerases are described as “magicians of the DNA world”. They allow DNA strands and double helices to “pass through each other” thereby resolving topological strain created during DNA replication and transcription.
  Plant Stem Cell formation
  Prof T Laux
Applications accepted all year round

Funding Type

PhD Type

We are seeking highly motivated candidates for a newly funded PhD position in plant embryo development. The goal is to investigate how the stem cells of the shoot meristem are formed during embryo development.
  The molecular mechanisms underlying reproductive organ photosynthesis
  Dr D O'Maoileidigh
Applications accepted all year round

Funding Type

PhD Type

Increasing crop yields while decreasing environmental impacts of agriculture is one of the major challenges facing modern society.
  Molecular mechanisms regulating the developmental plasticity of pancreatic cancer cells #NDORMS-2020/6
  Dr S Pauklin
Application Deadline: 10 January 2020

Funding Type

PhD Type

Pancreatic cancers are among the most lethal malignancies in human due to highly metastatic characteristics and the poor responsiveness to currently used cancer therapeutics.
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