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University of Sheffield, Department of Molecular Biology and Biotechnology Genetics PhD Projects, Programs & Scholarships

We have 12 University of Sheffield, Department of Molecular Biology and Biotechnology Genetics PhD Projects, Programs & Scholarships

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  BBSRC White Rose DTP Studentship - A novel bacteriophage defence system to control antibiotic resistant Campylobacter jejuni, the most prevalent food-borne pathogen
  Prof D J Kelly, Dr J Rafferty
Application Deadline: 6 January 2020

Funding Type

PhD Type

Campylobacter jejuni is the most common cause of food-borne gastroenteritis in the western world. Human infections result from consumption of contaminated chicken and the incidence has increased in recent years, including the emergence of multi-drug resistant campylobacters.
  BBSRC White Rose DTP Studentship - How increases in night-time temperature reduce seed yields
  Dr S Casson, Prof J Gray
Application Deadline: 6 January 2020

Funding Type

PhD Type

Rising global temperatures are predicted to have a major impact on crop productivity and global Food Security. One solution to this problem is to generate crops that show increased thermotolerance.
  Development of Intronless Expression Plasmids for Biomanufacturing of Therapeutic Proteins
  Prof S A Wilson, Dr E Thomson, Dr I Sudbery
Application Deadline: 10 January 2020

Funding Type

PhD Type

Therapeutic proteins such as antibodies are a successful class of biologic drug used to treat a wide range of diseases in areas such as oncology, respiratory, inflammation, autoimmunity and cardiology.
  Dissecting the mechanisms of antibiotic resistance in Clostridium difficile
  Dr R Fagan
Applications accepted all year round

Funding Type

PhD Type

Antibiotic resistance in pathogenic bacteria is one of the greatest health challenges facing humanity today.
  How do antibiotics kill bacteria?
  Prof S J Foster
Applications accepted all year round

Funding Type

PhD Type

Despite being a lynchpin of modern healthcare we still do not understand how cell wall active antibiotics such as penicillin and vancomycin kill growing bacteria, although several theories have been proposed.
  MRC DiMeN Doctoral Training Partnership: Development of an automated analysis pipeline to study bacterial cell wall structure and resistance to beta-lactam antibiotics
  Dr S Mesnage, Dr M Collins
Application Deadline: 6 January 2020

Funding Type

PhD Type

The most widely used antibiotics ever discovered (beta-lactams) are targeting the enzymes that polymerize peptidoglycan (PG), the essential component of the bacterial cell wall.
  MRC DiMeN Doctoral Training Partnership: How do non-coding enhancer RNAs confer genetic risk in Amyotrophic Lateral Sclerosis (ALS)?
  Dr Dan Bose, Dr J Cooper-Knock
Application Deadline: 6 January 2020

Funding Type

PhD Type

Project. Amyotrophic Lateral Sclerosis (ALS) is an aggressive neurodegenerative disease with no effective therapy. The established genetic causes of ALS can only explain a small fraction of the observed disease phenotypes.
  MRC DiMeN Doctoral Training Partnership: How does the human innate immune system kill the Streptococcus pneumoniae bacterium during infection?
  Dr A Fenton, Dr L Prince
Application Deadline: 6 January 2020

Funding Type

PhD Type

Background. The bacterium Streptococcus pneumoniae is a highly successful human pathogen and a leading cause of pneumonia, a disease responsible for millions of deaths every year.
  MRC DiMeN Doctoral Training Partnership: How to kill a difficult superbug: understanding the evolution of antimicrobial resistance in Clostridioides difficile
  Dr R Fagan, Prof M Brockhurst
Application Deadline: 6 January 2020

Funding Type

PhD Type

Increasing resistance to antibiotics is one of the greatest health challenges facing humanity today. Clostridioides difficile is the primary cause of antibiotic-associated infections in UK hospitals and antibiotic-induced disruption of the gut microbiota is a prerequisite for infection.
  Photoreceptor regulation of plant development
  Dr S Casson
Applications accepted all year round

Funding Type

PhD Type

Plant growth and development is highly dependent on the light environment. Light provides energy to drive photosynthesis but light quality and quantity is also perceived by photoreceptors, which signal to regulate responses enabling plants to adapt to their environment.
  Tetraspanin structure and function
  Dr L J Partridge
Applications accepted all year round

Funding Type

PhD Type

The tetraspanins are a diverse, conserved family of eukaryotic membrane proteins. Their principal feature is the ability to form dynamic multi-molecular assemblies in cell membranes known as tetraspanin enriched microdomains (TEM).
  The regulation of Staphylococcus aureus cell division
  Prof S J Foster
Applications accepted all year round

Funding Type

PhD Type

Staphylococcus aureus is a major human pathogen causing significant death and disease around the world. The problem is exacerbated by the spread of antibiotic resistant strains.
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