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University of Oxford, Radcliffe Department of Medicine Genetics PhD Projects, Programs & Scholarships

We have 8 University of Oxford, Radcliffe Department of Medicine Genetics PhD Projects, Programs & Scholarships

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Radcliffe Department of Medicine  University of Oxford

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We have 8 University of Oxford, Radcliffe Department of Medicine Genetics PhD Projects, Programs & Scholarships

Recombination mechanisms in immunity and cancer

Genomic instability (GI) is a hallmark of cancer that plays a central role in its initiation and development. GI can arise as a result of germline and somatic mutations that compromise a cell’s ability to accurately sense, signal or repair DNA damage. Read more

Origins of Genotoxic metabolism and the DNA damage response in stem and cancer cells

Our work has shown that metabolism both generalized and intrinsic to blood stem cells unleashes reactive metabolites such as the aldehydes – formaldehyde and acetaldehyde. Read more

Single Cell Biology of Hematopoietic Stem- and Progenitor Cells in Blood Cancer and Ageing

The focus of the Nerlov laboratory is combining single cell biology (single cell RNAseq, ATACseq and functional analysis) with advanced mouse genetics to study hematopoietic stem– and progenitor cells in normal development and during ageing. Read more

De Novo Mutations and Human Disease

De novo mutations (DNMs) are a significant contributor to human disease, affecting ~1:300 new births. We study the mechanisms by which these spontaneous mutations arise in the first instance, concentrating on the tissue where most of them originate, the human testis. Read more

Deciphering the role of white and brown adipocytes in metabolic disease

Our work focuses on understanding how obesity drives the development of type 2 diabetes and cardiovascular disease. Specifically, it aims to decipher molecular determinants of adipocyte number and distribution within the body; key factors of susceptibility to obesity-associated cardiometabolic diseases. Read more
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