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University of Birmingham Genetics PhD Projects, Programs & Scholarships

We have 26 University of Birmingham Genetics PhD Projects, Programs & Scholarships

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Showing 1 to 26 of 26
  Investigating the role of lysine methylation in the DNA damage response.
  Dr M Higgs
Applications accepted all year round

Funding Type

PhD Type

Our genomic DNA is under constant attack from DNA damaging agents, which are a continuing threat to genomic integrity. Defective resolution of DNA damage underlies several human diseases, including haematopoietic abnormalities and developmental disorders as well as cancer.
  Regulation of autophagy in human embryonic stem cells and its therapeutic application in induced pluripotent stem cell-based disease models
  Dr S Sarkar
Applications accepted all year round

Funding Type

PhD Type

Project background. Regulation of proteostasis is critical for maintaining tissue homeostasis. Autophagy, a major intracellular degradation pathway essential for cellular and energy homeostasis, functions in the clearance of aggregation-prone proteins and damaged organelles.
  The importance of the DNA damage response in neurodegeneration
  Dr R Tuxworth
Applications accepted all year round

Funding Type

PhD Type

DNA damage occurs in early-stage neurodegenerative diseases. The response of neurons to the damage may contribute to disease progression by inducing senescence, cell-cycle and apoptosis.
  The impact of genomics education on professional practice
  Dr S Buckley, Prof J Parry, Dr H Brown
Application Deadline: 29 September 2019

Funding Type

PhD Type

In October 2018, NHS England launched a world leading Genomic Medicine Service that builds on 30+ years’ experience of delivering clinical and laboratory genetic services, and on advances in whole genome sequencing resulting from the 100,000 genomes project.
  Analysing immune responses to metastatic ovarian tumours to identify therapeutic targets
  Dr J H Caamano, Dr D Withers
Applications accepted all year round

Funding Type

PhD Type

Research interests/description of main research theme. Ovarian cancer remains the most lethal gynaecological malignancy for women over 50 years old (1).
  Investigating how ovarian tumours avoid immune responses in cancer patients
  Dr J H Caamano, Dr D Withers
Applications accepted all year round

Funding Type

PhD Type

Research interests/description of main research theme. Ovarian cancer remains the most lethal gynaecological malignancy for women over 50 years old (1).
  Identification of novel regulators of pancreatic beta-cell identity
  Dr I Akerman
Application Deadline: 31 October 2019

Funding Type

PhD Type

Diabetes is the largest epidemic in human history that affects 1 in 12 adults worldwide. Due to our modern lifestyle, it is one of the few diseases where the incidence is set to rise dramatically, with projections putting 650 million people at risk by 2040.
  Polo-like kinase inhibitors for targeted therapy in adrenocortical carcinoma
  Dr C L Ronchi, Dr P Foster
Applications accepted all year round

Funding Type

PhD Type

Adrenocortical carcinoma (ACC) is a rare cancer with a generally poor prognosis and partially unknown pathogenesis.
  Repairing DNA Damage in Response to BRAF Mutation
  Dr C McCabe, Prof G Stewart
Applications accepted all year round

Funding Type

PhD Type

We are the leading thyroid cancer research group in the UK; we work on other neoplasias as well, including breast and head and neck etc.
  Elucidating the emergence of multi-drug resistant Enterococcus faecium
  Prof W Van Schaik, Dr A McNally
Applications accepted all year round

Funding Type

PhD Type

The Gram-positive bacterium Enterococcus faecium is a commensal of the intestinal tract of humans and animals. However, over the last two decades a clone of E.
  Analysis of pathogen determinants recognized by the hypervariable immune receptor Dscam
  Dr M Soller
Applications accepted all year round

Funding Type

PhD Type

Background. To mount an immune response, host organisms must first recognize the pathogen with which they are infected. The first line of defense against pathogen infection in animals is provided through the innate immune response.
  BBSRC MIBTP - Identification of pathways deregulating neuronal ELAV/Hu RNA binding proteins and alternative splicing in neurodegeneration
  Research Group: BBSRC MIBTP
  Dr M Soller, Dr M Tomlinson
Applications accepted all year round

Funding Type

PhD Type

ELAV/Hu proteins comprise a family of highly conserved neuronal RNA binding proteins important for the development of the nervous system and for neuronal functions.
  Biodiversity conservation ex situ or in situ with a focus on genetic diversity.
  Dr N Maxted
Applications accepted all year round

Funding Type

PhD Type

Field studies, ecogeography, geographic information systems and estimation of patterns of genetic diversity, IUCN taxonomic and genetic threat assessment will help elucidate conservation strategies and taxonomic clarity of critically endanged plant species.
  Eukaryotic gene expression: understanding the role of UPF1 in global mRNA processing and amyotrophic lateral sclerosis (ALS)
  Dr S Brogna
Applications accepted all year round

Funding Type

PhD Type

This project’s specific objective is to study the molecular role(s) that the RNA helicase UPF1 plays in RNA processing. UPF1 is a key player in nonsense-mediated mRNA decay (NMD), it is universally conserved in eukaryotes and is essential to the development of many organisms [1].
  Genetic and molecular mechanisms of brain structural plasticity and neurodegeneration
  Research Group: BBSRC MIBTP
  Dr A Hidalgo
Applications accepted all year round

Funding Type

PhD Type

The project will test the potential of a molecular mechanism that we recently discovered, in modulating brain structural plasticity versus neurodegeneration.
  Genetic and molecular mechanisms of nervous regeneration and repair
  Dr A Hidalgo
Applications accepted all year round

Funding Type

PhD Type

The project will aim to discover novel molecular mechanisms that could promote central nervous system regeneration. The focus will be on how neurons and glia interact to match their cell populations and functions, and on the regenerative potential of glial cells.
  Investigating the influence of polyploidy on the evolution of a major human fungal pathogen
  Dr E Ballou
Applications accepted all year round

Funding Type

PhD Type

The human fungal pathogen Cryptococcus neoformans undergoes an unusual morphological transition from haploid yeast to highly polyploid Titan cells during infection of the human host.
  Methods for quantitative genetic analyses in autotetraploids
  Prof Z Luo
Applications accepted all year round

Funding Type

PhD Type

Methods for quantitative genetic analysis have been well established in almost all important diploid plants and animal including humans, and have served as essential tools for dissecting the genetic architectures underlying agronomically, evolutionarily and medically interesting quantitative and complex traits.
  Molecular genetic characterization of Drosophila reproductive behaviours for exploitation in insect population control
  Research Group: BBSRC MIBTP
  Dr M Soller
Applications accepted all year round

Funding Type

PhD Type

Female reproductive behaviours in most insects profoundly change after mating leading to rejection of courting males and induction of egg laying.
  mRNA epigenetics: Charaterization of a novel layer of gene regulation for essential brain functions
  Research Group: BBSRC MIBTP
  Dr M Soller, Dr PG Grzechnik
Applications accepted all year round

Funding Type

PhD Type

For over 40 years we know about modified nucleotides in mRNA, but the functions for these essential modifications are largely elusive.
  Multimerisation of ELAV/Hu proteins – a key mechanism ensuring specificity for RNA recognition in health and disease
  Dr M Soller, Dr T Knowles
Applications accepted all year round

Funding Type

PhD Type

Aims. Determine the structure of the ELAV dodecameric complex bound to target RNA by cryoEM and functionally probe interaction interfaces in vitro and in vivo in transgenic Drosophila models for neurodegeneration and cancer.
  Neural basis underlying mating decisions in fruit flies
  Dr C Rezaval
Applications accepted all year round

Funding Type

PhD Type

Mate choice is an essential behavioural process with profound consequences in evolution. How do animals choose with whom to mate? How do they evaluate the features of a potential mate to maximise their reproductive success?.
  Statistical and Molecular Genetics of Complex Traits
  Prof Z Luo
Applications accepted all year round

Funding Type

PhD Type

Most characters of any living organism are polygenically controlled and environmentally modified, including those threatening human health and those important in breeding for high yield, better quality and improved adaption of animals, plants and microbes.
  Statistical genetics and genomics of complex traits
  Dr L Leach, Prof Z Luo
Applications accepted all year round

Funding Type

PhD Type

A highly motivated student is sought to train as a statistical geneticist working on the dissection of complex trait phenotypes in human, plant and animal populations into their underlying genetic components.
  Statistical methods for integrating multi-omics sequence data and unveiling molecular underpinnings of non-small cell lung cancer
  Prof Z Luo, Dr L Leach
Applications accepted all year round

Funding Type

PhD Type

The past decade has witnessed tremendous advancements in sequencing technologies, enabling collection of highly accurate and high resolution data on the structure and function of the genome.
  Understanding cholera pandemics
  Research Group: BBSRC MIBTP
  Dr D Grainger, Dr P A Lund
Applications accepted all year round

Funding Type

PhD Type

Vibrio cholerae is the causative agent of Cholera. Millions of cases of the disease occur every year and these are responsible for $3.1 billion dollar financial losses.
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