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University of Liverpool Genetics PhD Projects, Programs & Scholarships

We have 51 University of Liverpool Genetics PhD Projects, Programs & Scholarships

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Showing 1 to 10 of 51
  Characterization and functional analysis of a novel cancer-associated gene
  Dr JP de Magalhaes
Applications accepted all year round
In order to identify new candidate cancer-related genes, our lab developed a bioinformatics “guilt-by-association” method to identify and rank genes that are co-expressed with known cancer-related genes.
  Developing and applying computational methods to understand the genetics of ageing
  Dr JP de Magalhaes
Applications accepted all year round
Ageing is the chief biomedical challenge of the 21st century, yet it remains a major puzzle of biology. Although it is clear that the process of ageing has a strong genetic component, much work remains to elucidate how the genome regulates ageing.
  Functional and –omics investigation of neutrophil activation in rheumatoid arthritis
  Dr HL Wright, Prof RJ Moots, Dr M Phelan
Applications accepted all year round
Neutrophils are key effector cells in the pathogenesis of autoimmune diseases such as rheumatoid arthritis (RA), systemic lupus erythematosus and vasculitis.
  Identifying nutrient and pesticide modulation of ion channels with Artificial Intelligence (AI)
  Dr R Barrett-Jolley
Application Deadline: 11 January 2019
Many pesticides and food nutrients that animals (including people) are exposed to can have subtle, but potentially dangerous toxic effects by interactions with ion channels.
  microRNAs as tools to regulate senescence of musculoskeletal cells during ageing
  Dr K Whysall, Prof P Clegg
Application Deadline: 22 November 2019
As the ageing population continues to increase, it is important to address ageing-related health issues. There is currently no effective treatments for many common musculoskeletal (MSK) disorders, such as sarcopenia or osteoarthritis, which increase in prevalence during ageing.
  Molecular analysis of neutrophil extracellular traps (NETs) in rheumatoid arthritis
  Dr HL Wright, Prof RJ Moots
Applications accepted all year round
Neutrophil extracellular traps (NETs) kill pathogens via the release of chromatin and anti-microbial granule enzymes in an extracellular mesh or “net”.
  Post-transcriptional gene regulation during chondrogenesis
  Dr S Tew
Application Deadline: 11 January 2019
Healthy cartilage in our joints is essential for us to maintain an active life into old age. The cells that maintain cartilage are called chondrocytes and have a specialised phenotype that is initiated during development and then maintained throughout our lives.
  Targeting ageing: Genes and compounds with pro-longevity, health-preserving effects
  Dr JP de Magalhaes
Applications accepted all year round
Ageing is arguably the major biomedical challenge of the 21st century. In model organisms, the process of ageing can be manipulated by both genetic manipulations and dietary interventions.
  The role of modified microRNAs in fibrosis during ageing
  Dr K Whysall, Prof G Bou-Gharios
Application Deadline: 22 November 2019
MicroRNAs (miRNAs) are small, non-coding RNAs that regulate the expression of multiple mRNAs posttranscriptionally (Brown & Goljanek-Whysall, Aging Res Rev 2015).
  Understanding the role of TNFRSF11B polymorphisms in osteoprotegerin bioavailability and bone metabolism
  Dr A Daroszewska, Prof R van ‘t Hof
Applications accepted all year round
This project will focus on determining the effect of the polymorphisms of the TNFRSF11B gene, which encodes osteoprotegerin (OPG), on bone metabolism.
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