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University of Sheffield Genetics PhD Projects, Programs & Scholarships

We have 31 University of Sheffield Genetics PhD Projects, Programs & Scholarships

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  Earthworms and sustainable agriculture
  Dr P J Watt
Applications accepted all year round

Funding Type

PhD Type

Worldwide, soils are in a poor state, through erosion, compaction and the loss of organic carbon, and so it is essential that we manage them in order to maintain the productivity of agricultural land.
  Environmentally induced epigenetic effects in a fish
  Dr P J Watt
Applications accepted all year round

Funding Type

PhD Type

Animals may be exposed to a wide range of environmental stimuli over the course of their development, some of which may be harmful, such as pollutants, and these may subsequently affect their behaviour and/or physiology and that of their offspring.
  How does clubroot obtain nutrients from its living plant host?
  Dr S A Rolfe
Applications accepted all year round

Funding Type

PhD Type

Clubroot is an important pathogen of Brassica crops. The disease is found throughout the world and causes severe economic losses.
  PhD in cellular and structural biology - Elucidating infection at the plant-microbe interphase to define targets for crop breeding
  Dr C Voigt
Applications accepted all year round

Funding Type

PhD Type

Achieving food security is one of the most important global challenges. Crop production and yield has been increasingly threatened by plant pathogens in a rapidly changing environment.
  PhD in evolutionary genetics
  Prof J Slate
Applications accepted all year round

Funding Type

PhD Type

Our group integrates genomics approaches and tools with ecological data collected from long-term studies of vertebrates. We aim to understand how genetic variation is maintained and how evolutionary change occurs.
  PhD in plant genetics and molecular biology
  Dr L Smith
Applications accepted all year round

Funding Type

PhD Type

My group is interested in understanding aspects of basic plant biology, primarily through the application of molecular biology and genetics.
  PhD in population genetics
  Dr K Zeng
Applications accepted all year round

Funding Type

PhD Type

Our research combines theoretical development and empirical data analysis. In particular, we are interested in developing new methods for analyzing DNA sequence data, and applying them to real datasets.
  PhD in the Evolutionary Ecology of Mating Systems
  Dr S Campbell
Applications accepted all year round

Funding Type

PhD Type

Mating and breeding systems govern a wide range of evolutionary processes in plants and animals, including gene flow, genetic variation, and the strength of natural selection.
  The genetics/genomics of adaptive evolutionary change
  Dr N Nadeau
Applications accepted all year round

Funding Type

PhD Type

The basic process of evolution by natural selection involves genetic changes that confer an advantage in survival or reproduction.
  Welfare and stress related effects in laboratory-reared fishes
  Dr P J Watt
Applications accepted all year round

Funding Type

PhD Type

There has been much interest in the rearing conditions of both commercial and laboratory fishes and the welfare implications of these.
  Analysis of the role of Hypoxia Inducibe Factor pathway in radioprotection
  Dr F Van Eeden
Application Deadline: 29 January 2020

Funding Type

PhD Type

Hypoxia inducible factor (HIF) is highly important in human health and disease, as is testified by the 2019 Nobel prize for Medicine or Physiology.
  Identification of the molecular pathways that guide zebrafish regeneration.
  Dr H Roehl
Application Deadline: 29 January 2020

Funding Type

PhD Type

The study of regenerative biology aims to elucidate the innate ability of organisms to replace tissues or organs after they have been removed or damaged.
  Targeting pathogen subversion of cellular ageing to combat antimicrobial-resistant typhoid fever
  Dr D Humphreys, Dr T Darton
Application Deadline: 29 January 2020

Funding Type

PhD Type

Antimicrobial-resistant typhoid fever is fuelled by chronic Salmonella carriage. The world faces epidemics of untreatable typhoid fever caused by antimicrobial-resistant strains of Salmonella Typhi (~27 million cases/year).
  Bacterial iron uptake pathways as targets for the development of novel antimicrobials
  Dr M Thomas
Applications accepted all year round

Funding Type

PhD Type

Antimicrobial resistance is an ever increasing problem. Presently it is estimated to be responsible for 700,000 deaths p.a. and it is predicted that this figure will rise to 10 million by 2050.
  Identifying inhibitors specific to the OPG-kinome: towards novel treatments for Pulmonary Arterial Hypertension (PAH).
  Prof A Lawrie, Dr R Thompson
Applications accepted all year round

Funding Type

PhD Type

Background. Pulmonary arterial hypertension (PAH) is a fatal progressive disease. Median life expectancy in untreated PAH patients is 2.8 years.
  Optogenetic programming of inflammation - in vivo Opto-GPCR approaches in neutrophils.
  Prof S Renshaw, Prof A Condliffe
Application Deadline: 29 January 2020

Funding Type

PhD Type

White blood cells called neutrophils have a powerful protective role and without them we develop overwhelming infection, yet they are also directly responsible for the tissue damage that characterises many common inflammatory diseases.
  Transport of essential nutrients across the outer membrane of a bacterial pathogen
  Dr M Thomas
Applications accepted all year round

Funding Type

PhD Type

Gram-negative bacteria possess a second membrane, the outer membrane (OM), that serves as an additional line of defence against noxious agents, including antibiotics.
  Using the fly kidney to develop new treatments for genetic kidney diseases
  Prof A Ong, Dr N Bulgakova
Applications accepted all year round

Funding Type

PhD Type

Polycystic kidney disease is the most common hereditary cause of kidney failure in man. It comprises a spectrum of diseases of which Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most common form in adults and Nephronophthisis (NPHP) the most common form in children.
  Dissecting the mechanisms of antibiotic resistance in Clostridium difficile
  Dr R Fagan
Applications accepted all year round

Funding Type

PhD Type

Antibiotic resistance in pathogenic bacteria is one of the greatest health challenges facing humanity today.
  How do antibiotics kill bacteria?
  Prof S J Foster
Applications accepted all year round

Funding Type

PhD Type

Despite being a lynchpin of modern healthcare we still do not understand how cell wall active antibiotics such as penicillin and vancomycin kill growing bacteria, although several theories have been proposed.
  Photoreceptor regulation of plant development
  Dr S Casson
Applications accepted all year round

Funding Type

PhD Type

Plant growth and development is highly dependent on the light environment. Light provides energy to drive photosynthesis but light quality and quantity is also perceived by photoreceptors, which signal to regulate responses enabling plants to adapt to their environment.
  Tetraspanin structure and function
  Dr L J Partridge
Applications accepted all year round

Funding Type

PhD Type

The tetraspanins are a diverse, conserved family of eukaryotic membrane proteins. Their principal feature is the ability to form dynamic multi-molecular assemblies in cell membranes known as tetraspanin enriched microdomains (TEM).
  The regulation of Staphylococcus aureus cell division
  Prof S J Foster
Applications accepted all year round

Funding Type

PhD Type

Staphylococcus aureus is a major human pathogen causing significant death and disease around the world. The problem is exacerbated by the spread of antibiotic resistant strains.
  Investigating Dipeptide Repeat Interactions in Drosophila Models of C9Orf72 Related Frontotemporal Dementia and Motor Neuron Disease
  Dr R West, Dr G Hautbergue
Application Deadline: 29 January 2020

Funding Type

PhD Type

Frontotemporal Dementia (FTD) and Motor Neurone Disease (MND) are two overlapping neurodegenerative disorders. A large repeat expansion (GGGGCC) mutation in the C9Orf72 locus is the most common genetic cause of both Frontotemporal Dementia and Motor Neurone Disease.
  Longitudinal multi-omics of host–microbe dynamics in amyotrophic lateral sclerosis
  Dr J Cooper-Knock, Prof C McDermott
Application Deadline: 29 January 2020

Funding Type

PhD Type

Amyotrophic lateral sclerosis (ALS, or motor neuron disease) is a rapidly progressive and invariably fatal neurodegenerative condition.
  Longitudinal study on the relationship of the gut microbiome to disease progression in the UK MND population
  Prof C McDermott, Dr S Boddy
Applications accepted all year round

Funding Type

PhD Type

Motor neurone disease (MND) is a devastating neurodegenerative condition characterised by progressive deterioration of motor functions until death normally results from respiratory failure.
  Oral vitamin D spray as a novel treatment for 22q11 deletion syndrome
  Dr A McNeill, Dr C Mazzà
Applications accepted all year round

Funding Type

PhD Type

22q11 deletion syndrome is the most common genetic disorder, affecting about 1/2500 people (as common as cystic fibrosis). It is due to a small missing piece of chromosome 22 on the long arm (q) at position 11.
  What is the impact of atypical neurogenesis on brain activity, cognition and behaviour?
  Dr A McNeill, Dr M Freeth
Applications accepted all year round

Funding Type

PhD Type

Neurogenesis is the process by which stem cells form brain cells. This process is disrupted by genetic mutations causing childhood neurological disorders which cause symptoms such as learning disability, behaviour problems and epilepsy.
  Characterisation of in vitro models of human salivary glands and their use in functional studies
  Dr L Bingle, Prof C Bingle
Applications accepted all year round

Funding Type

PhD Type

Saliva is produced by three pairs of major salivary glands and multiple minor glands in the lips, associated with the tongue and also with the palate.
  The Role of Fusion Genes Tumourigenesis
  Dr L Bingle, Prof C Bingle
Applications accepted all year round

Funding Type

PhD Type

Salivary gland tumours are uncommon but have a varied and complex pattern of histopathological features.
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