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We have 36 Human Genetics PhD Projects, Programmes & Scholarships for European Students (exc UK)
Human Genetics PhD Projects, Programmes & Scholarships for European Students (exc UK)
We have 36 Human Genetics PhD Projects, Programmes & Scholarships for European Students (exc UK)
Genetic and molecular underpinnings of obesity - using veterinary models for insight into human disease
Why are some individuals prone to obesity and yet others stay lean in an obesogenic environment? Obesity is highly heritable as are related metabolic traits. Read more
Exploring the role of hyaluronan in cognition across the lifespan
The project. Good cognitive health, the ability to think, learn and remember, is of vital importance across species, contributing to a productive life and sense of wellbeing. Read more
Molecular distinction between arrhythmogenic cardiomyopathy and Brugada syndrome
Sudden cardiac death (SCD) is a leading cause of mortality claiming over 6 million lives annually worldwide. And yet we have no truly effective ways to prevent it, mainly because we do not understand it. Read more
Determining the role of the adaptive immune system in controlling breast cancer metastasis and evolution.
Immune responses involve a balanced interplay between the evolution of a target alongside the evolution of the immune system. The immune system prevents cancer by evolving to recognise and eliminate cancer cells. Read more
(MRC DTP) Investigating the role of small RNA molecules in neuronal function and genetic disease
MicroRNAs are a class of highly conserved ~22 nucleotide non-coding RNAs that impact gene expression through binding to target sequences in messenger RNAs (mRNA). Read more
(MRC DTP) Understanding mechanisms of cell vulnerabilities identified in Notch driven breast cancer
Understanding the molecular basis of an individual's cancer and tailoring therapy accordingly is an approach which has in some cases led to reduced mortality. Read more
(MRC DTP) Using multi-omic approaches to diagnose, discover and understand genetic disorders
Background. More than 50% patients with suspected genetic disorders remain unsolved even after whole genome sequencing. Our group has a successful history of employing cutting edge approaches to improve diagnosis of rare diseases and discover novel diseases. Read more
(MRC DTP) Neural crest specific regulation of chromatin regulators and their role in neurocristopathies
The neural crest (NC) is an embryonic stem cell-like population that contributes to a remarkable range of tissues in the vertebrate body, including craniofacial features, the peripheral nervous system and some cardiac structures. Read more
(MRC DTP) Identifying the functional effects of risk loci in rheumatic disease using CRISPR screens
Juvenile Idiopathic Arthritis (JIA) affects approximately 12,000 children in the UK. There is no cure and up half of children fail to improve on current therapies, leading to long-term disability and decreased quality of life. Read more
(MRC DTP) The impact of cell division on the decoding of oscillatory gene expression during neurogenesis
In order to ensure that a properly structured and functioning nervous system is produced the generation of neurons from stem cells must be carefully controlled. Read more
(MRC DTP) Racopathy neurodevelopmental disorders: from mechanism to treatment
RAC1 is a key cellular signalling hub, integrating signals from multiple upstream regulators and transmitting these signals to numerous downstream effectors. Read more
(MRC DTP) Translating genetic discoveries to improve the accuracy of predicting cardiovascular outcomes in patients with rheumatic musculoskeletal diseases
The accurate estimation of an individual’s risk of cardiovascular disease (CVD) is essential for timely intervention with preventative treatments. Read more
(MRC DTP) Graphene-based Drug Delivery for Kidney Disease caused by Mutation in HNF1B
Heterozygous mutations in HNF1B are the commonest genetic cause of human kidney malformations. Moreover, postnatally, kidney tubule physiology is deficient characterised by electrolyte (Mg2+ and K+)wasting into the urine. Read more
(MRC DTP) Investigations into proton radiation in chromosomal instability- and telomere spectrum disorders
Chromosomal instability- and telomere spectrum disorders (CITSDs), such as Bloom syndrome (BS), Fanconi anaemia (FA), Nijmegen Breakage syndrome (NBS) or Dyskeratosis Congenita (DKC) are inherited conditions with variable congenital and developmental abnormalities and impaired ability to maintain chromosomal integrity. Read more
(MRC DTP) A bioinformatics approach to identify pathogenic immune cell clusters relevant for human autoimmune diseases.
Background. Inflammatory arthritis (IA) can result from non-autoimmune diseases (like crystal arthritis) and from autoimmune diseases like rheumatoid arthritis (RA) and spondyloarthropathies (inc. Read more