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University of Sheffield, Infection, Immunity and Cardiovascular Disease PhD Projects, Programs & Scholarships

We have 7 University of Sheffield, Infection, Immunity and Cardiovascular Disease PhD Projects, Programs & Scholarships

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  Bacterial iron uptake pathways as targets for the development of novel antimicrobials
  Dr M Thomas
Applications accepted all year round

Funding Type

PhD Type

Antimicrobial resistance is an ever increasing problem. Presently it is estimated to be responsible for 700,000 deaths p.a. and it is predicted that this figure will rise to 10 million by 2050.
  Characterisation of bacterial effectors delivered by the type VI secretion system
  Dr M Thomas
Applications accepted all year round

Funding Type

PhD Type

Many pathogenic bacteria secrete protein ’effectors’ that benefit the pathogen by allowing it to subvert, damage or kill the host.
  How does cytokine signalling cause kidney hyperplasia?
  Dr M Fragiadaki, Prof J Sayers
Applications accepted all year round

Funding Type

PhD Type

Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic kidney disorder, with more than 12 million people are affected worldwide.
  Identifying inhibitors specific to the OPG-kinome: towards novel treatments for Pulmonary Arterial Hypertension (PAH).
  Prof A Lawrie, Dr R Thompson
Applications accepted all year round

Funding Type

PhD Type

Background. Pulmonary arterial hypertension (PAH) is a fatal progressive disease. Median life expectancy in untreated PAH patients is 2.8 years.
  Transport of essential nutrients across the outer membrane of a bacterial pathogen
  Dr M Thomas
Applications accepted all year round

Funding Type

PhD Type

Gram-negative bacteria possess a second membrane, the outer membrane (OM), that serves as an additional line of defence against noxious agents, including antibiotics.
  TRIB3 at the interface of metabolism and inflammation in adipose tissue
  Dr H Wilson, Prof E Kiss-Toth
Applications accepted all year round

Funding Type

PhD Type

Obesity drives chronic inflammation and immune activation. This results in dysregulated metabolism, insulin resistance linked to diabetes, cardiovascular disease and cancer.
  Using the fly kidney to develop new treatments for genetic kidney diseases
  Prof A Ong, Dr N Bulgakova
Applications accepted all year round

Funding Type

PhD Type

Polycystic kidney disease is the most common hereditary cause of kidney failure in man. It comprises a spectrum of diseases of which Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most common form in adults and Nephronophthisis (NPHP) the most common form in children.
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