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University of Birmingham, Institute of Cancer and Genomic Sciences PhD Projects, Programmes & Scholarships
We have 9 University of Birmingham, Institute of Cancer and Genomic Sciences PhD Projects, Programmes & Scholarships
We have 9 University of Birmingham, Institute of Cancer and Genomic Sciences PhD Projects, Programmes & Scholarships
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Dissecting the role of novel haematopoietic factors in development and disease
Blood is made up of different cell types with different functions, such as carrying oxygen (red blood cells), help with wound healing (platelets) and fighting infections (white blood cells). Read more
Using iPSC-derived neurons and CRISPR-Cas9 to model rare human neurodevelopmental and neuropsychiatric diseases
Research interests/description of main research theme. Applications are invited for a 3-year fully-funded PhD Studentship starting in October 2023 in the laboratory of Dr Martin Higgs at the University of Birmingham. Read more
Haematopoietic stem cell dysfunction in ageing and disease
Adult organs are maintained by specialised stem cells that persist throughout life thanks to their ability to make exact copies of themselves, all the time retaining the ability to on demand produce the differentiated component cells of the tissue of which they are a part. Read more
Role of APC/C subunit post-translational modifications on the function of the APC/C in mitosis
The APC/C is a large macromolecular E3 ubiquitin ligase, that, through targeting protein substrates for polyubiquitylation and 26S proteasome-mediated degradation coordinates the progression of cells through mitosis (1, 2). Read more
Viral regulation of host cell DNA damage response pathways
Human adenoviruses are small non-enveloped viruses and possess a linear, double-stranded DNA genome. Adenovirus has long been used as a tool to dissect the molecular basis of key biological processes such as growth, differentiation and death. Read more
The role of PHF6 during haematopoietic differentiation
PHD finger protein 6 (PHF6) is a protein, consisting of two atypical plant homeodomains (aPHD1/2) with nuclear and nucleolar localization sequences. Read more
Transcription factor complexes in Acute Myeloid Leukaemia
Acute Myeloid Leukaemia (AML) is a group of blood cancers, resulting from uncontrolled cellular proliferation of cells belonging to the myeloid lineage. Read more
Defining the transcription roles of BRCA1 and BRCA2
BRCA1 and BRCA2 mutations predispose to both breast and ovarian cancers, with both factors playing many crucial roles in DNA damage repair and response. Read more
Role of RNA-DNA hybrids and transcription-replication conflicts in colorectal cancer
Replication stress, or replication-associated DNA damage, occurs frequently in cancer. There is a growing interest in targeting oncogene-induced replication stress for cancer therapy. Read more
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