We have 18 University of Liverpool, Institute of Systems, Molecular and Integrative Biology PhD Projects, Programmes & Scholarships
University of Liverpool, Institute of Systems, Molecular and Integrative Biology PhD Projects, Programmes & Scholarships
We have 18 University of Liverpool, Institute of Systems, Molecular and Integrative Biology PhD Projects, Programmes & Scholarships
Mathematical Modelling of Cell Shape and Localised Cell growth.
The correct cell shape is essential for proper cell function. For example, in the brain signalling between neurons is received by dendritic spines, Dendritic spines are protrusions on the surface of the neuron, they come in different shapes, the most well-known being mushroom shaped. Read more
Conjugated polymer nanoparticles for fluorescence-guided intraoperative tumour visualization
Every year there are 900,000 new cases of head and neck cancer (HNC) worldwide. Unfortunately, the number of people being diagnosed and dying of this disease in Liverpool is significantly higher than the rest of England, and in some deprived areas, higher than parts of India and South Africa. Read more
Personalising cancer treatment with tumour evolution modelling using AI-based genomics biomarkers and PK/PD
Tumour heterogeneity is a major problem limiting the efficacy of targeted oncological therapies. Most advanced tumours eventually become resistant to the treatments, ultimately making the patient succumb to metastatic disease. Read more
Investigating the metabolic response of low and high dietary vitamin A intake in humans using cell and mammal models
Introduction: Nutrients we consume from food have many important biological roles in relation to growth, development and ageing in humans. Read more
Translating Deep Learning protein bioinformatics methods to accelerate structural determination by X-ray crystallography
Even after the AlphaFold 2 (AF2) revolution, experimental structural biology contributes enormously to advances across all areas of biology. Read more
Improving chemical and immunological assessment to drive safer development of the new breed of drugs: PROTACS
Proteolysis-targeting chimeras (PROTACs) are a new class of drugs with immense potential across multiple therapeutic areas in drug development. Read more
Development and validation of the Epilepsy-Heart syndrome: a focus on ictal asystole and developing evidence-based national consensus guidelines
An exciting new opportunity has arisen for a PhD student interested in cardiovascular science, neuroscience (or cardiology and neurology) and health data science to help us develop and validate a condition we believe exists. Read more
The evolution of large brains and complex cognition across animal taxa
The evolution of advanced cognitive abilities in animals has been heavily studied in some vertebrates, notably mammals and birds. Read more
Chromatin regulation of oncogenic transcription and replication stress: mechanism and functional implications in acute myeloid leukemia
This project focuses on the molecular mechanisms promoting acute myeloid leukaemia (AML), a disease of great unmet need. AML is an aggressive blood and bone marrow cancer characterized by abnormal proliferation and differentiation of myeloid cells. Read more
Investigating how tumour associated macrophages affect cancer metastasis and response to therapies
Solid tumours are generally highly infiltrated by macrophages. Macrophages are heterogeneous and different populations with different and sometimes even opposite functions co-exist in tumours affecting cancer progression. Read more
Exploiting Deep Learning-based protein structure prediction for function annotation and structural biology
Applications will be reviewed until a suitable candidate is appointed. Protein structural information is crucial for an understanding of protein function and evolution. Read more
Biological pathways supporting the formation and function of chromatin (Scholarship)
Every cell in our body contains the same DNA yet each cell expresses a different set of genes. These changes in gene expression are heavily influenced by histone proteins, their role in packaging DNA into chromatin and the “epigenetic” information they carry. Read more
Exploring the roles of dynamic atypical protein phosphorylation in cancer
Proteins are extensively regulated by dynamic, often reversible post-translational modifications (PTMs). This process allows cells to respond rapidly to environmental factors, be that e.g. Read more
Investigating the cellular functions of Trappc9 in brain development and microcephaly
This PhD project will investigate the cellular functions of the Trafficking protein particle complex subunit 9 (Trappc9) and its roles in brain development. Read more
Engineering more water-use efficient crops: functional genomics of CO2 fixation during Crassulacean acid metabolism
The world is getting hotter and drier due to climate change, and the human population is growing rapidly. Furthermore, it has been predicted that we will need to increase crop yields by 50 - 70 % by 2050 in order to feed the predicted 9 - 10 billion people. Read more
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