Lipid nanocapsules (LNCs) are very interesting nanoformulations as they can be made by phase inversion technique (PIT), a scalable method with predictable particle size at the beginning of the preparation process. Read more
To decrease the risk of acute infective exacerbations or flare-ups of their condition, individuals with bronchiectasis and COPD are frequently prescribed long-term oral and inhaled antibiotics. Read more
The student will be involved in an exciting project related to the design, formulation and in vitro/in vivo characterisation of super small drug nanocrystals with specific surface properties to enhance drug accumulation in target tissues, such as the lymphatic or central nervous systems. Read more
Community medical and nursing teams are increasingly called upon to deliver palliative and end-of-life care to terminally ill people living in their own homes and in long-term care settings such as nursing homes. Patients and carers may experience problems in medicines access, and processes can be lengthy and burdensome. Read more
Gene therapy has the potential to provide therapeutic benefit to millions of people with neurodegenerative diseases and cancer. Delivery into the brain is hampered by the blood-brain barrier (BBB), which limits the efficacy of both conventional and novel therapies at the target site. Read more
Implantable medical devices are commonplace in modern medicine (e.g. joint replacements, stents, artificial heart valves, etc.), and are of ever increasing interest in the field of regenerative medicine. Read more
Progress in drug design has led to the development of new molecules. However, the limited ability to selectively deliver these molecules at well-defined dosing regimens remains a significant challenge. Read more
Polymer–drug conjugate (PDCs) therapeutics are pharmacologically active macromolecular constructs comprising at least one therapeutic agent covalently bound to a polymeric carrier. Read more
Medicines management is a complex process for people living with dementia (PLWD), who often have other comorbidities and are frequently prescribed multiple regular medicines. Read more
USP17 is over-expressed in a range of primary tumours (NSCLC, breast, colorectal, cervical, ovarian, osteosarcoma) and its depletion blocks the growth, and migration, of cells from all of these cancer types. Read more
Many infections and disease states are closely linked to associated microbiomes, either of the patient themselves or the surrounding clinical environment. Read more
Breast Cancer (BC) is the most common cancer in the UK, accounting for 15% of new cancer cases. There is a significant unmet clinical need to understand why some cancers do not respond to treatment and what drives metastasis. Read more
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