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Medical Research Council (Cambridge), Laboratory of Molecular Biology PhD Projects, Programs & Scholarships

We have 31 Medical Research Council (Cambridge), Laboratory of Molecular Biology PhD Projects, Programs & Scholarships

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Showing 1 to 10 of 31
  Application of Bayesian statistics and machine learning to interpretation, refinement and validation of cryoEM maps as atomic models
  Dr G Murshudov
Application Deadline: 3 December 2019

Funding Type

PhD Type

Macromolecules play an important role in almost all the stages of all biological processes. Knowledge of their three-dimensional structures help understanding these processes, which in turn may help to fight diseases, e.g.
  Cryo-electron tomography of HIV-1 assembly and maturation
  Dr J Briggs
Application Deadline: 3 December 2019

Funding Type

PhD Type

Retroviruses are enveloped RNA viruses, whose assembly is largely driven by the viral Gag polyprotein. Gag recruits other virion components and targets them to the viral assembly site.
  Dissecting neural circuits for goal-oriented actions
  Dr M Tripodi
Application Deadline: 3 December 2019

Funding Type

PhD Type

Movement is our only way to interact with the environment, to explore it and modify it. We study the organization and function of neural circuits controlling movement in mice, with particular focus on goal oriented movements.
  How cells transform cytosol-invading bacteria into anti-bacterial signalling platforms
  Dr F Randow
Application Deadline: 3 December 2019

Funding Type

PhD Type

The cytosol of mammalian cells appears an attractive niche for bacterial pathogens since it is rich in nutrients. However, perhaps surprisingly, most intracellular bacteria avoid the cytosol and rather reside inside membrane-surrounded vacuoles.
  How does epithelial tissue organization modulate pluripotent stem cell identity and fate?
  Dr M Shahbazi
Application Deadline: 3 December 2019

Funding Type

PhD Type

During embryogenesis pluripotent stem cells give rise to all the cell types present in the organism. How pluripotent cells decide their fate is a fundamental question in development and regeneration.
  How structured DNA drives epigenetic variation
  Dr J Sale
Application Deadline: 3 December 2019

Funding Type

PhD Type

During DNA replication the usually stable DNA duplex is unwound providing an opportunity for the exposed single strands to adopt non-B form structures such as hairpins, triplexes and quadruplexes, which can then impede DNA synthesis.
  Information and function in synthetic genetic polymers
  Dr P Holliger
Application Deadline: 3 December 2019

Funding Type

PhD Type

Life is based on the capacity of the nucleic acids DNA and RNA to encode, store and propagate genetic information. However, whether their unique role in biology reflects evolutionary history or fundamental functional constraints, whether nature’s “choice” was shaped by chance or necessity, is currently unknown.
  Investigating mechanisms of protein aggregate transmission in C. elegans
  Dr R Taylor
Application Deadline: 3 December 2019

Funding Type

PhD Type

The transfer of toxic, aggregated forms of proteins between cells drives the progression of neurodegenerative diseases. However, the mechanisms driving this propagation are not yet fully understood.
  Investigating the structure and function of the divisome, the multi-protein complex that facilitates cell division in bacteria.
  Dr J Lowe
Application Deadline: 3 December 2019

Funding Type

PhD Type

When bacteria and archaea divide, most form a ring structure that facilitates the separation of mother and daughter cells. The best-known component of the cytokinetic ring is FtsZ, the bacterial tubulin homologue.
  Kidneys in a dish: epithelial polarity and tube formation in human renal organoids
  Dr K Roeper
Application Deadline: 3 December 2019

Funding Type

PhD Type

Epithelia constitute one of the major tissue types in all animals and form the basic building blocks of tubular organs in both vertebrates and invertebrates.
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