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Biochemistry PhD Projects, Programs & Scholarships in Leeds

We have 38 Biochemistry PhD Projects, Programs & Scholarships in Leeds

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Leeds  United Kingdom

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We have 38 Biochemistry PhD Projects, Programs & Scholarships in Leeds

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Epigenetics and Cancer: Determining how Mistakes in V(D)J Recombination Trigger Leukaemias and Lymphomas

  Research Group: School of Molecular and Cellular Biology
V(D)J recombination is essential to produce an effective adaptive immune system but since the reaction involves the breakage and rejoining of DNA, it is highly dangerous and errors have long been thought to lead to leukaemias and lymphomas. Read more

Developing methods for Cryo-EM using Affimers to understand blood clotting

This studentship provides world class training in cryo-EM, molecular biology and protein biochemistry. The project will focus on developing cryo-EM methods to characterise proteins to understand the clotting process, a leading cause of morbidity. Read more

Probing a novel allosteric binding site in Mycobacterium DNA gyrase to tackle TB and antimicrobial resistance

Human pathogenic bacteria, e.g. Mycobacterium tuberculosis (TB), show increasing resistance to current antibiotics. Antimicrobial resistance (AMR) is probably the biggest current threat to human health; it is estimated that 10 million people per year could die because of AMR by 2050. Read more

Using our expertise to develop future scientists - BHF Four Year Programme

Soon, 1 in 10 UK adults will have diabetes. In spite of modern treatments, most of these people will suffer major cardiovascular problems, including heart attack and stroke, impairing their quality of life and survival. Read more

Wrapping virus-like particles in polymer films using protein-carbohydrate interactions

  Research Group: School of Chemistry
Polymer films are widely used as barriers to protect objects from their environments or improve their performance.? What if tiny nano- or micron-sized objects could also be wrapped in thin layers of polymer films? Would they also gain benefits from their inclusion in wrappers in the same ways as macroscopic objects do? These questions lead to tantalising possibilities. Read more

Investigation of antagonism of multiple RGD-binding integrins as a therapeutic strategy in advanced head and neck cancer

  Research Group: Institute of Cancer Therapeutics
Background. The integrins are a family of transmembrane receptors which mediate cell-cell and cell-ECM adhesion, and signalling across the cell membrane involved in pathways controlling cell migration, proliferation, differentiation, cell survival and apoptosis. Read more

Development of a personalized therapy for pulmonary arterial hypertension (PAH)

  Research Group: Pharmacology and Experimental Therapeutics
Pulmonary arterial hypertension (PAH) is a devastating cardiovascular disorder which, if left untreated, leads to heart failure and death. Read more

Therapeutic resolution of coronavirus (COVID-19) diseases by natural products

  Research Group: Pharmacology and Experimental Therapeutics
Coronavirus now labelled as Covid-19 has become a global pandemic affecting around 200 countries. Currently neither any cure nor any vaccine for Covid-19 has been established. Read more

Therapeutic resolution of pulmonary arterial hypertension (PAH) by natural products

  Research Group: Pharmacology and Experimental Therapeutics
Pulmonary arterial hypertension (PAH) is a devastating cardiovascular disorder which, if left untreated, leads to heart failure and death. Read more

Navigating through sequence space to understand Alpha-Synuclein Aggretion

The aggregation of the 140 residue protein a-synuclein into amyloid fibres is associated with neurodegenerative diseases known as synucleinopathies including Parkinson’s disease (the second most common neurodegenerative disease worldwide). Read more

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