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Biochemistry PhD Projects, Programs & Scholarships in Leeds

We have 52 Biochemistry PhD Projects, Programs & Scholarships in Leeds

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Showing 1 to 10 of 52
  Why do proteins aggregate under flow?
  Dr D Brockwell, Prof S E Radford
Application Deadline: 15 March 2019
The function and stability of proteins are intimately linked to their environment and consequently, changes in environmental factors such as pH can trigger conformational changes that in turn modulate protein function.
  Posttranslational modifications of the tumor suppressor PTCH1: characterisation and functional significance
  Dr N.A. Riobo-Del Galdo, Prof R.W. Bayliss
Application Deadline: 10 March 2019
PTCH1, the receptor of the Hedgehog family of proteins and a well-characterised tumor suppressor, is a 12-transmembrane protein with long intracellular N- and C-termini (1).
  Rational design and production of glyco-peptidic inhibitors of pathogens’ adhesion to host cells.
  Research Group: Astbury Centre for Structural Molecular Biology
  Dr E Paci, Prof W B Turnbull
Application Deadline: 30 September 2019
The ability of protein molecules to stick to cells is crucial for life and disease. The project is based on a novel concept to design adhesive molecules based on multivalence and entropic stabilisation.
  Epigenetics and Cancer: Determining how Mistakes in V(D)J Recombination Trigger Leukaemias and Lymphomas
  Research Group: School of Molecular and Cellular Biology
  Dr J Boyes
Applications accepted all year round
V(D)J recombination is essential to produce an effective adaptive immune system but since the reaction involves the breakage and rejoining of DNA, it is highly dangerous and errors have long been thought to lead to leukaemias and lymphomas.
  Epigenetics and Cancer: Development of Novel Tools to Determine how Aberrant V(D)J Recombination Reactions Cause Leukaemia
  Dr J Boyes
Applications accepted all year round
V(D)J recombination generates a highly diverse set of immunoglobulin and T cell receptor genes to enable vertebrates to fight a vast range of infections.
  Targeting addiction to a breast cancer metastasis survival pathway by inhibition of RAN GTPase
  Research Group: Institute of Cancer Therapeutics
  Dr S Shnyder, Prof M El-Tanani, Dr S Betmouni
Applications accepted all year round
Metastatic cancer is a major global health burden. Each year, eleven million new cases of cancer are diagnosed worldwide, including 5 million cases in industrialized countries.
  Ran GTPase as a potential novel therapeutic target in EMT transdifferentiation and breast cancer stem cell (BCSC) survival during metastatic development
  Research Group: Institute of Cancer Therapeutics
  Prof R Morgan, Prof M El-Tanani, Dr M Isreb, Dr M Najafzadeh
Applications accepted all year round
Breast cancer is the leading cause of cancer death in women worldwide. Accumulating evidence suggests that local disease recurrence and metastatic lesions, the major causes of patient mortality, are due to a subset of aggressive cells termed cancer stem cells (CSCs).
  Structural biology of membrane proteins
  Research Group: Astbury Centre for Structural Molecular Biology
  Dr C Pliotas
Application Deadline: 15 March 2019
Research in the Pliotas group focuses on the investigation of molecular mechanisms which underlie the structure and function of integral membrane proteins, in particular ion channels and transporters.
  Pattern Formation (Applied Nonlinear Dynamics): understanding the formation and stability of complex patterns such as quasipatterns, spatio-temporal chaos or turbulent spirals
  Prof A M Rucklidge
Applications accepted all year round
Regular patterns, such as stripes, squares and hexagons, are ubiquitous in nature, and their formation and stability are governed by the intricate and complex interactions of symmetry and nonlinearity.
  Impact of RhoA deregulation on smooth muscle cell phenotypic dysfunction in Type 2 diabetes
  Research Group: Chemistry and Biosciences
  Dr K Riches-Suman
Applications accepted all year round
Type 2 diabetes (T2D) is an escalating healthcare burden. It inflicts significant physical and emotional distress on patients and their carers, and treatment of T2D and its complications accounts for ~10% of the entire NHS budget.
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