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We have 28 Biochemistry PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships in Leeds

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Leeds  United Kingdom

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Biochemistry PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships in Leeds

We have 28 Biochemistry PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships in Leeds

A PhD in Biochemistry would provide you with the time and resources to undertake an in-depth research project into one area of biochemistry. These projects are almost always laboratory-based and can range from investigating the structure and role of a protein or receptor to developing and optimising current detection methods.

What’s it like to do a PhD in Biochemistry?

Doing a PhD in Biochemistry, you’ll develop wide-spread laboratory skills including protein purification, western blotting, chromatography, and polymerase chain reaction (PCR). The use of cutting-edge equipment such as nuclear magnetic resonance (NMR) is common in Biochemistry and consequently you’ll become proficient with these fine instruments.

Some typical research topics in Biochemistry include:

  • Engineering enzymes for industry
  • Characterising the structure and function of proteins
  • Developing novel therapeutics
  • Understanding the role of redox in a system or disease
  • Investigation of a specific receptor
  • Developing and optimising methods (such as NMR)

Day-to-day you’ll be in the laboratory performing experiments, writing up and analysing data from previous experiments and discussing your results and research plans with colleagues.

Biochemistry programmes are almost always advertised research projects, with the key aim pre-determined by the supervisor. Although the aim is set, you are still free to influence the direction of the project along the way. These advertised programmes usually come with full funding attached.

It is uncommon to propose your own research in Biochemistry as you must find a supervisor with research goals that overlap with your project, who also has adequate equipment for your experimental work, and you must find sufficient funding for bench and PhD fees.

Regardless of being funded or not, your PhD will end with a thesis of around 60,000 words, which contributes significantly to the knowledge of the field. To be awarded your PhD, you’ll then need to defend your thesis during your viva exam.

Entry requirements

The entry requirements for most Biochemistry PhD programmes involve a Masters in a subject directly related to Biochemistry such as Biology or Chemistry, with at least a Merit or Distinction. If English isn’t your first language, you’ll also need to show that you have the right level of language proficiency.

PhD in Biochemistry funding options

The Research Council responsible for funding Biochemistry PhDs in the UK is the Biotechnology and Biological Sciences Research Council (BBSRC). They provide fully-funded studentships including a stipend for living costs, a consumables budget for bench fees and a tuition fee waiver. Students don’t apply directly to the BBSRC, you apply for advertised projects with this funding attached.

It’s uncommon for Biochemistry PhD students to be ‘self-funded’ due to the additional bench fees. However, if you were planning to fund yourself it might be achievable (depending on your project) through the UK government’s PhD loan and part-time work.

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Therapeutic resolution of pulmonary arterial hypertension (PAH) by natural products

  Research Group: Pharmacology and Experimental Therapeutics
Pulmonary arterial hypertension (PAH) is a devastating cardiovascular disorder which, if left untreated, leads to heart failure and death. Read more

Therapeutic resolution of coronavirus (COVID-19) diseases by natural products

  Research Group: Pharmacology and Experimental Therapeutics
Coronavirus now labelled as Covid-19 has become a global pandemic affecting around 200 countries. Currently neither any cure nor any vaccine for Covid-19 has been established. Read more

Investigation of antagonism of multiple RGD-binding integrins as a therapeutic strategy in advanced head and neck cancer

  Research Group: Institute of Cancer Therapeutics
Background. The integrins are a family of transmembrane receptors which mediate cell-cell and cell-ECM adhesion, and signalling across the cell membrane involved in pathways controlling cell migration, proliferation, differentiation, cell survival and apoptosis. Read more

ERK5 MAPK signalling in Alzheimer’s disease

  Research Group: Pharmacology and Experimental Therapeutics
Neurodegenerative diseases have devastating effects on individuals’ lives and our society, with no effective treatments available. Read more

Development of a personalized therapy for pulmonary arterial hypertension (PAH)

  Research Group: Pharmacology and Experimental Therapeutics
Pulmonary arterial hypertension (PAH) is a devastating cardiovascular disorder which, if left untreated, leads to heart failure and death. Read more

Epigenetics and Cancer: Determining how Mistakes in V(D)J Recombination Trigger Leukaemias and Lymphomas

  Research Group: School of Molecular and Cellular Biology
V(D)J recombination is essential to produce an effective adaptive immune system but since the reaction involves the breakage and rejoining of DNA, it is highly dangerous and errors have long been thought to lead to leukaemias and lymphomas. Read more

Polysialyltransferases as a target in metastatic cancer

  Research Group: Institute of Cancer Therapeutics
Polysialic acid plays an essential role in neuronal development, but by adulthood is absent from the human body. Its biosynthesis is regulated by two polysialyltransferases. Read more

Nanoparticle synthesis and application in magnetic field hyperthermia for cancer therapy

  Research Group: Chemistry and Biosciences
Magnetic field hyperthermia (MFH) is currently undergoing clinical trials for use in humans. The research to date has shown the effectiveness of the approach in cells and animal models and the initial results from human trials are promising. Read more

Investigation into the in-vitro lung deposition of liposomal formulations of the dual fixed-dose combination inhaler

  Research Group: Medicines Development and Pharmaceutical Sciences
Asthma and Chronic Obstructive Pulmonary Disease (COPD) are diseases associated with the airflow in the lungs (WHO, 2013). Inhalation is the most effective route of administration for treating asthma and COPD (Labiris and Dolovich, 2003). Read more

Formulation and biopharmaceutical characterisation of novel pro-antibiotics for improved oral permeability

  Research Group: Medicines Development and Pharmaceutical Sciences
This project is focused on the formulation, synthesis, and biopharmaceutical characterisation of novel pro-antibiotics for improved oral bioavailability. Read more

Design, synthesis and evaluation of protease-activated anti-cancer prodrugs

  Research Group: Institute of Cancer Therapeutics
Matrix metalloproteinases (MMPs) are a family of endoproteases that are overexpressed in tumours and play crucial roles in many tumourigenic processes, not least tumour invasion and angiogenesis. Read more

Design, synthesis and evaluation of novel polysialyltransferase inhibitors as anti- metastatic agents

  Research Group: Institute of Cancer Therapeutics
Polysialic acid plays an essential role in neuronal development, but by adulthood is absent from the human body. Its biosynthesis is regulated by two polysialyltransferases (polySTs). Read more

Core and core-shell nanomaterials synthesis for Optoelectronics

  Research Group: Chemistry and Biosciences
Nanoscience and technology, which involves the manipulation of materials using the property of size to bring about specific desired changes in the electronic structure of materials, has proven to be a powerful additional tool permitting the materials scientist to effect greater control over the charge transport properties in materials. Read more

Metabolic reprogramming in cancer: starving tumors of essential nutrients to promote cell death

All the cells in our bodies are programmed to die. As they get older, our cells accumulate toxic molecules that make them sick. In response, they eventually break down and die, clearing the way for new, healthy cells to grow. Read more

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