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Biophysics PhD Projects, Programs & Scholarships in Leeds

We have 16 Biophysics PhD Projects, Programs & Scholarships in Leeds

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Showing 1 to 15 of 16
  Nanoparticle-based Therapeutics to Combat Multidrug Resistance and Biofilms in Chronic Wound Infections
  Research Group: Molecular and Nanoscale Phsyics
  Dr Z Ong, Dr J R McLaughlan
Applications accepted all year round

Funding Type

PhD Type

Chronic wound infections are a significant and fast-growing global healthcare problem compounded by the widespread occurrence of antibiotic-resistant bacteria.
  A mechanistic understanding of allosteric regulation of neuronal sodium-activated potassium channels
  Research Group: School of Biomedical Sciences
  Dr J D Lippiat, Dr S Muench, Dr A Kalli
Applications accepted all year round

Funding Type

PhD Type

The sodium-activated potassium channel KNa1.1 (KCNT1, Slack, Slo2.2) is found in neurons and couples sodium influx to excitability.
  Learning from plant cell walls as a path for innovations in food and material sciences
  Dr Y Benitez-Alfonso, Dr C Bosch
Applications accepted all year round

Funding Type

PhD Type

The research will dissect the structural factors controlling cell walls and cell communication for two main purposes. to improve the health value of food crops and to design strategies for the valorisation of wasted plant materials.
  Nanoinjection: a single molecule technique to study amyloid toxicity in neurons
  Research Group: Astbury Centre for Structural Molecular Biology
  Dr E W Hewitt, Prof S E Radford, Dr P Actis
Applications accepted all year round

Funding Type

PhD Type

Interested in amyloid disorders such as Parkinson’s and Huntington’s. Want to work with cutting edge technology in a multidisciplinary team.
  Enhancing stability of biocatalyst for fuel cells and bioelectrocatalysis
  Prof L J C Jeuken, Dr P Beales
Applications accepted all year round

Funding Type

PhD Type

Progress in biotechnology over the last two decades has greatly increased the use of biocatalyst in the industrial production of fine chemicals.
  Structural insights into ligand binding and channel gating in ATP-gated P2X7 receptor
  Research Group: School of Biomedical Sciences
  Dr L H Jiang, Dr S Muench
Applications accepted all year round

Funding Type

PhD Type

P2X7 receptor, belonging to the ATP-gated ion channel P2X receptor family, exhibits distinct functional and pharmacological properties that are crucial for its role in innate immunity and inflammatory diseases and cancers (Jiang et al., 2013; Caseley et al., 2014; Roger et al., 2014; Wei et al., 2018).
  TRPM2 channel mechanism of neuroinflammation and neurodegeneration in Alzheimer’s disease
  Research Group: School of Biomedical Sciences
  Dr L H Jiang, Dr I Wood
Applications accepted all year round

Funding Type

PhD Type

Alzheimer’s disease (AD) is the most common cause of dementia and also a major cause of morbidity and mortality. Currently, there is no effective therapeutics to treat or slow the disease progress.
  Epigenetic therapy using ultrasound-mediated microbubble drug delivery for cancer treatment
  Dr E Valleley, Dr L Coletta
Applications accepted all year round

Funding Type

PhD Type

The project is an interdisciplinary, pre-clinical study that aims to investigate the response of human tumour cells to treatment with epigenetic inhibitors (such as DNA methyltransferase inhibitors), as a potential combination therapy for colorectal cancer (CRC).
  Computer Simulations of Biological Macromolecules
  Research Group: Molecular and Nanoscale Phsyics
  Dr SA Harris
Applications accepted all year round

Funding Type

PhD Type

Computational models are invaluable for visualisation in molecular biology, as they employ our best quantitative physical understanding of biomolecules and their interactions to predict their dynamics, which is often missing from biophysical experiments.
  Seeing photosynthesis at the nanoscale: mapping physical properties of light-harvesting biomembranes by high-resolution microscopy and spectroscopy
  Research Group: Molecular and Nanoscale Phsyics
  Dr P.G. Adams, Dr G Heath
Applications accepted all year round

Funding Type

PhD Type

Understanding photosynthesis could provide valuable clues for future solar technology and help our understanding of food crops.
  Direct characterisation of TRPC channel dynamics triggered by drug-like modulators using high-speed atomic force microscopy
  Research Group: Molecular and Nanoscale Phsyics
  Dr G Heath
Applications accepted all year round

Funding Type

PhD Type

The rapid expansion in the structural understanding of membrane proteins through recent progress in electron microscopy and X-ray crystallography is leading to an ever greater need for techniques which provide high temporal resolution dynamics.
  New approaches for studying and understanding Cancer
  Research Group: Molecular and Nanoscale Phsyics
  Prof SD Evans
Applications accepted all year round

Funding Type

PhD Type

One of the key questions in cancer research is what drives cells to switch from a normal healthy state to a cancerous one, in which they continually divide and reproduce.
  Synthetic Virology: Development of gene delivery vectors/synthetic vaccines
  Research Group: Astbury Centre for Structural Molecular Biology
  Prof P G Stockley
Applications accepted all year round

Funding Type

PhD Type

There is worldwide interest in exploiting our modern understanding of genomics to target gene expression therapeutically via a variety of mechanisms, such as transgene insertion and CRISPR-Cas gene editing.
  Defining a novel assembly pathway in ssRNA viruses using X-ray footprinting.
  Prof P G Stockley
Applications accepted all year round

Funding Type

PhD Type

Project co-supervised by Prof. Peter Stockley at Leeds and Prof. Reidun Twarock at University of York, as part of the White Rose network "Structural and Mechanistic Biology at the RNA/Ligand Interface".
  Mathematical Virology: A New Mathematical Approach to Viral Evolution Grounded in Experiment
  Research Group: Astbury Centre for Structural Molecular Biology
  Prof P G Stockley
Applications accepted all year round

Funding Type

PhD Type

Mathematical modelling of natural phenomena has the potential to be predictive but requires direct verification by experiment. Such models can then be very powerful indicators of our understanding and they permit in silico simulations of situations that are difficult to test experimentally.
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