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Cancer / Oncology PhD Projects, Programs & Scholarships in Leeds

We have 29 Cancer / Oncology PhD Projects, Programs & Scholarships in Leeds

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Showing 1 to 15 of 29
  A ‘Metastasis-On-A-Chip’ Microphysiological Model of Cancer Metastasis to Bone
  Dr M Amer, Dr V Pensabene, Prof F Meldrum
Application Deadline: 1 July 2020

Funding Type

PhD Type

Bone is a frequent site of cancer metastases and usually indicates poor clinical prognosis. Metastasis of tumour cells in the bone marrow is a dynamic process, and cell behaviour is regulated by three-dimensional (3D) cell-cell and cell-matrix interactions with its microenvironment.
  Using AI to combine genomic with pathology images to improve lymphoma diagnosis
  Research Group: School of Molecular and Cellular Biology
  Prof D R Westhead, Dr R Tooze
Application Deadline: 15 June 2020

Funding Type

PhD Type

Primary Supervisor. Prof David Westhead, Faculty of Biological Sciences (https://biologicalsciences.leeds.ac.uk/molecular-and-cellular-biology/staff/154/professor-david-r-westhead).
  Investigating the mechanism of action of dual antiangiogenic/ antineoplastic drugs using organotypic co-culture of fibroblasts and endothelial cells
  Research Group: Institute of Cancer Therapeutics
  Dr J Elies Gomez, Dr K Pors
Applications accepted all year round

Funding Type

PhD Type

An important feature of many types of cancer is the ability to develop abnormal angiogenesis (blood vessel formation); this allows cancer cells to gain access to nutrients and favours metastasis.
  Design, synthesis and evaluation of novel polysialyltransferase inhibitors as anti- metastatic agents
  Research Group: Institute of Cancer Therapeutics
  Dr R Falconer, Dr S Shnyder
Applications accepted all year round

Funding Type

PhD Type

Polysialic acid plays an essential role in neuronal development, but by adulthood is absent from the human body. Its biosynthesis is regulated by two polysialyltransferases (polySTs).
  Polysialyltransferases as a target in metastatic cancer
  Research Group: Institute of Cancer Therapeutics
  Dr R Falconer, Dr S Shnyder
Applications accepted all year round

Funding Type

PhD Type

Polysialic acid plays an essential role in neuronal development, but by adulthood is absent from the human body. Its biosynthesis is regulated by two polysialyltransferases.
  Design, synthesis and evaluation of protease-activated anti-cancer prodrugs
  Research Group: Institute of Cancer Therapeutics
  Dr R Falconer, Prof P Loadman
Applications accepted all year round

Funding Type

PhD Type

Matrix metalloproteinases (MMPs) are a family of endoproteases that are overexpressed in tumours and play crucial roles in many tumourigenic processes, not least tumour invasion and angiogenesis.
  Kinase regulation of HOX transcription factors – a potential target in cancer?
  Research Group: Institute of Cancer Therapeutics
  Prof R Morgan, Dr S Shnyder
Applications accepted all year round

Funding Type

PhD Type

The HOX genes are a family of transcription factors that have a number of important functions in cancer, including cell survival and metastasis.
  Discovery of chemical and biological tools to probe hypoxic solid tumours
  Research Group: Institute of Cancer Therapeutics
  Dr K Pors, Dr J Elies Gomez
Applications accepted all year round

Funding Type

PhD Type

A major challenge in cancer therapy is to develop therapeutic agents that selectively target tumour cells. One avenue towards the development of more selective cancer therapies is to exploit the unique physiological properties of solid tumours using prodrug approaches.
  Aldehyde dehydrogenase expression and function in cancer stem cells
  Research Group: Institute of Cancer Therapeutics
  Dr K Pors, Dr A Mardaryev, Prof A Locke
Applications accepted all year round

Funding Type

PhD Type

Aldehyde dehydrogenases (ALDHs) catalyse the oxidation and detoxification of reactive endogenous and exogenous aldehydes into carboxylic acids via NAD+ coupled reduction.
  Development of heterocyclic pharmacophores using diversity-oriented synthesis
  Research Group: Institute of Cancer Therapeutics
  Dr K Pors, Prof L Patterson
Applications accepted all year round

Funding Type

PhD Type

Diversity-oriented synthesis (DOS) is a modern chemical tool, which aims to synthesise small molecules that cover new chemical space with the possibility of finding unexplored biological targets or pathways that may be important for disease progression.
  New strategies in integrin antagonism
  Research Group: Institute of Cancer Therapeutics
  Dr H Sheldrake
Applications accepted all year round

Funding Type

PhD Type

The integrins are a family of transmembrane receptors which mediate cell-cell and cell-ECM adhesion, and signalling across the cell membrane involved in pathways controlling cell migration, proliferation, differentiation, cell survival and apoptosis.
  Endosomal Sorting Complex Required for Transport (ESCRT): Investigation of the role in acquired drug resistance in colon cancer
  Research Group: Institute of Cancer Therapeutics
  Dr S Shnyder, Dr S Kantamneni
Applications accepted all year round

Funding Type

PhD Type

Despite treatment advances, one of the most common cancers, colorectal cancer (CRC), still has a 45% mortality rate, and one of the major problems is the build-up of resistance to cancer drugs during treatment (‘acquired resistance’) such that over time the drugs stop working.
  Glutamatergic pharmacology and receptor modifications underlying cognitive function in a rodent model of schizophrenia
  Research Group: Pharmacology and Experimental Therapeutics
  Dr K Pors, Dr S McLean, Dr S Kantamneni
Applications accepted all year round

Funding Type

PhD Type

Cognitive deficits are recognised as being a core symptom of psychiatric disorders including schizophrenia.
  Formulation and evaluation of umbilical cord-derived mesenchymal stem cells exosomes and antioxidants, incorporated in nanoliposomes using microfluidics, for the treatment of solid tumours
  Research Group: Chemistry and Biosciences
  Dr M Najafzadeh, Prof D Anderson, Dr M Isreb
Applications accepted all year round

Funding Type

PhD Type

This project uses the Cord blood Stem Cells from healthy control and the white blood cells of blood cancer patients to investigate the efficacy and genotoxicity of different compounds in them by using various genetic endpoints.
  Biomarkers of Genotoxic and Reprotoxic Effects after chemical exposure in vitro in human cells
  Research Group: Chemistry and Biosciences
  Prof D Anderson, Dr M Najafzadeh
Applications accepted all year round

Funding Type

PhD Type

In human monitoring procedures, measurements obtained from endpoints to determine genetic damage are sometimes referred to as biomarkers.
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