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We have 47 Cancer Biology PhD Projects, Programmes & Scholarships in Leeds

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Cancer Biology PhD Projects, Programmes & Scholarships in Leeds

We have 47 Cancer Biology PhD Projects, Programmes & Scholarships in Leeds

University of Bradford

Making Knowledge Work at the University of Bradford

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University of Leeds

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Endosomal Sorting Complex Required for Transport (ESCRT): Investigation of the role in acquired drug resistance in colon cancer

University of Bradford Faculty of Life Sciences
  Research Group: Institute of Cancer Therapeutics
Despite treatment advances, one of the most common cancers, colorectal cancer (CRC), still has a 45% mortality rate, and one of the major problems is the build-up of resistance to cancer drugs during treatment (‘acquired resistance’) such that over time the drugs stop working. Read more
 Supervisors: Dr S Shnyder, Dr S Kantamneni
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Development of Naked Mole Rat Colonic Crypt Models to Use in the Search for Bowel Disease Preventatives

University of Bradford Faculty of Life Sciences
  Research Group: Institute of Cancer Therapeutics
Diseases affecting the bowel such as colorectal cancer (CRC) and the inflammatory bowel diseases (IBD) ulcerative colitis and Crohn’s disease are major global healthcare challenges in the 21st century. Read more
 Supervisors: Dr S Shnyder, Prof S El-Khamisy
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Design, synthesis and evaluation of protease-activated anti-cancer prodrugs

University of Bradford Faculty of Life Sciences
  Research Group: Institute of Cancer Therapeutics
Matrix metalloproteinases (MMPs) are a family of endoproteases that are overexpressed in tumours and play crucial roles in many tumourigenic processes, not least tumour invasion and angiogenesis. Read more
 Supervisors: Prof R Falconer, Prof P Loadman
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Design, synthesis and evaluation of novel polysialyltransferase inhibitors as anti- metastatic agents

University of Bradford Faculty of Life Sciences
  Research Group: Institute of Cancer Therapeutics
Polysialic acid plays an essential role in neuronal development, but by adulthood is absent from the human body. Its biosynthesis is regulated by two polysialyltransferases (polySTs). Read more
 Supervisors: Prof R Falconer, Dr S Shnyder
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Cancer: Investigation of accentuated mitochondrial ROS and NLRP3 inflammasome activation in cystic fibrosis and colorectal carcinoma.

University of Leeds Faculty of Medicine and Health
Cystic fibrosis (CF) is associated with an accentuated inflammatory response to bacterial lipopolysaccharides (LPS), increased resting energy expenditure and a higher than expected prevalence of gastrointestinal and other malignancies. Read more
 Supervisors: Prof D Peckham, Prof D Jayne, Dr S Savic, Miss LR Caley
 Open Day(s)  Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Cancer: Characterization of EGFR signaling activated by the endothelium in the process of breast cancer metastasis to the brain

University of Leeds Faculty of Medicine and Health
The Epidermal Growth Factor Receptor (EGFR) is important in normal physiology regulating epithelial development and homeostasis. In cancer, deregulation resulting from mutation, amplification or transcriptional upregulation promotes tumorigenesis. Read more
 Supervisors: Dr G Mavria, Dr S Bell
 Open Day(s)  Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Haematology: Oncogenic reprogramming of immune cells; novel mechanism for drug resistance in leukaemia

University of Leeds Faculty of Medicine and Health
Under pathogenic challenges, cells of the haematopoietic system become epigenetically reprogrammed and establish immune memory. Read more
 Supervisor: Dr P Laslo
 Open Day(s)  Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Oncology: Evaluating Photodynamic Therapy in colorectal cancer using patient-derived organoids

University of Leeds Faculty of Medicine and Health
Colorectal cancer (CRC) is the 3rd most common cancer worldwide. Surgery is first line treatment and often in adjunct with chemotherapy. Read more
 Supervisors: Dr I Knot, Prof D Jayne
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Translational Medicine: Understanding the mechanism(s) of resistance to EPA to personalise therapy and improve outcome

University of Leeds Faculty of Medicine and Health
Advanced colorectal cancer (CRC) is the UK’s second most lethal cancer, with limited treatment options for unresectable metastatic tumours. Read more
 Supervisors: Dr MA Volpato, Prof M Hull
 Open Day(s)  Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Cancer: Complex 3D modelling of the tumour microenvironment for immunotherapy combination screening

University of Leeds Faculty of Medicine and Health
Cancer immunotherapy holds significant promise for the treatment of a range of cancers. Read more
 Supervisors: Dr MA Volpato, Dr F Errington-Mais
 Open Day(s)  Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Virology: Unique Antiviral Therapy targeting Zika and Related Viruses

University of Leeds Faculty of Medicine and Health
Zika Virus (ZIKV) has emerged as a new mosquito-borne threat to public health after the devastating South American outbreak. Read more
 Supervisors: Dr S Griffin, Dr A Kalli, Dr C McKimmie
 Open Day(s)  Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Virology: Sun exposure as a novel risk factor for Zika virus infection

University of Leeds Faculty of Medicine and Health
Mosquito-borne disease is now receiving unprecedented attention due to major outbreaks in new geographic areas including Brazil, Mexico, India, China, the Middle East and SE Asia. Read more
 Supervisors: Dr C McKimmie, Dr K Shams, Dr S Griffin
 Open Day(s)  Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Immunotherapy: Manipulating T cell metabolism to improve anti-tumour immunity

University of Leeds Faculty of Medicine and Health
The induction of immune responses to tumours can provide long-lasting protection from cancer. In this regard, T cells can suppress tumour growth by directly killing cancer cells and by producing inflammatory cytokines. Read more
 Supervisors: Dr M Lorger, Dr R Salmond
 Open Day(s)  Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Haematology: Oncogenic reprogramming of immune cells

University of Leeds Faculty of Medicine and Health
Under pathogenic challenges, cells of the innate system become epigenetically reprogrammed and establish immune memory. Read more
 Supervisors: Dr F Errington-Mais, Dr P Laslo
 Open Day(s)  Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Clinical: Gastroesophageal reflux in respiratory disease: pathogenic role and improved management

University of Leeds Faculty of Medicine and Health
Gastroesophageal reflux disease (GERD) is a condition in which stomach contents, such as food and acid pass into the gullet/oesophagus causing heartburn. GERD is very common in patients with lung disease, such as idiopathic pulmonary fibrosis (IPF), chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF). Read more
 Supervisors: Prof L Houghton, Dr D Peckham
 Open Day(s)  Year round applications  PhD Research Project  Self-Funded PhD Students Only
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