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Microbiology PhD Projects, Programs & Scholarships in Leeds

We have 12 Microbiology PhD Projects, Programs & Scholarships in Leeds

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Leeds  United Kingdom

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We have 12 Microbiology PhD Projects, Programs & Scholarships in Leeds

Clinical Gastroenterology: The regulation of GDH expression in Clostridioides difficile

Clostridioides difficile infection (CDI), the most common cause of infective antibiotic-associated diarrhea in the western world, is diagnosed by a combination of tests that firstly detect the organism, then the toxins that it produces (Planche 2013). Read more

Understanding the structural consequences of ribosome specialisation

Protein synthesis by ribosomes (translation) and its regulation is essential to life. While it has been traditionally thought that ribosomes were not involved in the regulation of translation, it is now becoming clear that they do contribute. Read more

Clinical Gastroenterology: Investigation of Fidaxomicin Resistance Mechanisms in Clostridium difficile

Clostridium difficile is a leading pathogen in healthcare-associated diarrheal infections. C. difficile has a plastic genome with multiple mobile genetic elements and recognized capacity to acquire genes involved in resistance and virulence. Read more

Therapeutic resolution of coronavirus (COVID-19) diseases by natural products

  Research Group: Pharmacology and Experimental Therapeutics
Coronavirus now labelled as Covid-19 has become a global pandemic affecting around 200 countries. Currently neither any cure nor any vaccine for Covid-19 has been established. Read more

Using ex-vivo genetic systems as models to detect genetic susceptibility to co-morbidities in Covid 19 infection, and to test specific anti-inflammatory / antiviral drugs in Covid 19 infection

  Research Group: Chemistry and Biosciences
Research has shown that certain individuals are more susceptible to SARS-CoV-2. Approximately, 20–51% of COVID-19 patients presented with a least one co-morbidity on admission, with diabetes (10–20%) hypertension (10–15%) and other cardiovascular and cerebrovascular diseases (7–40%) being most prevalent. Read more

Development of transdermal protein liposomal delivery system for the treatment of dermatological diseases

  Research Group: Chemistry and Biosciences
Biopharmaceuticals have been increasingly used in the treatment of skin diseases. However, due to the poor absorption of peptide and protein through the skin, they are usually delivered through injections. Read more

Formulation and evaluation of umbilical cord-derived mesenchymal stem cells exosomes and antioxidants, incorporated in nanoliposomes using microfluidics, for the treatment of solid tumours

  Research Group: Chemistry and Biosciences
This project uses the Cord blood Stem Cells from healthy control and the white blood cells of blood cancer patients to investigate the efficacy and genotoxicity of different compounds in them by using various genetic endpoints. Read more

Dissecting the molecular mechanisms of antibiotic resistance in bacterial pathogens

  Research Group: Astbury Centre for Structural Molecular Biology
Antibiotics make possible the treatment and cure of life-threatening bacterial infections. Since their introduction in the middle years of the 20th Century, they have added ~10 years to the human lifespan, and have become a cornerstone of modern medicine. Read more

Towards new antibacterial drugs to treat infections caused by multidrug-resistant bacteria: identification and characterization of novel natural product antibiotics

  Research Group: Astbury Centre for Structural Molecular Biology
The World Health Organization (WHO) has declared antimicrobial drug resistance one of the greatest problems currently facing human health, and the situation is especially grave in the case of infections caused by bacterial pathogens. Read more
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