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Microbiology PhD Projects, Programs & Scholarships in Leeds

We have 11 Microbiology PhD Projects, Programs & Scholarships in Leeds

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Showing 1 to 10 of 11
  Aldehyde dehydrogenase expression and function in cancer stem cells
  Research Group: Institute of Cancer Therapeutics
  Dr K Pors, Dr A Mardaryev, Prof A Locke
Applications accepted all year round
Aldehyde dehydrogenases (ALDHs) catalyse the oxidation and detoxification of reactive endogenous and exogenous aldehydes into carboxylic acids via NAD+ coupled reduction.
  Dissecting the molecular mechanisms of antibiotic resistance in bacterial pathogens
  Research Group: Astbury Centre for Structural Molecular Biology
  Dr A O'Neill
Applications accepted all year round
Antibiotics make possible the treatment and cure of life-threatening bacterial infections. Since their introduction in the middle years of the 20th Century, they have added ~10 years to the human lifespan, and have become a cornerstone of modern medicine.
  Towards new antibacterial drugs to treat infections caused by multidrug-resistant bacteria: identification and characterization of novel natural product antibiotics
  Research Group: Astbury Centre for Structural Molecular Biology
  Dr A O'Neill
Applications accepted all year round
The World Health Organization (WHO) has declared antimicrobial drug resistance one of the greatest problems currently facing human health, and the situation is especially grave in the case of infections caused by bacterial pathogens.
  The role of tumour microenvironment interactions in melanoma therapy resistance
  Research Group: Institute of Cancer Therapeutics
  Dr H Sheldrake, Dr M Sutherland
Applications accepted all year round
The incidence of malignant melanoma has steadily increased over the past 30 years, and it is predicted that 76,250 new cases will be diagnosed in the US and over 10,000 in the UK this year.
  Synthesis and Characterisation of Proteolysis targeting chimeras (PROTACs), potential anticancer agents
  Research Group: Institute of Cancer Therapeutics
  Dr H Sheldrake
Applications accepted all year round
Proteolysis targeting chimeras (PROTACs) are bifunctional molecules consisting of a small molecule which binds a desired protein target, a linker, and a ligand which binds to an E3 ubiquitin ligase.
  Cytochromes P450 in Cancer: Opportunities for Development of Personalised Medicine - Project 1
  Research Group: Institute of Cancer Therapeutics
  Dr K Pors, Prof P Loadman
Applications accepted all year round
The improved understanding of cancer biology provides opportunities for the development of molecular targeted therapies.
  Development of transdermal protein liposomal delivery system for the treatment of dermatological diseases
  Research Group: Chemistry and Biosciences
  Dr M Najafzadeh, Prof D Anderson
Applications accepted all year round
Biopharmaceuticals have been increasingly used in the treatment of skin diseases. However, due to the poor absorption of peptide and protein through the skin, they are usually delivered through injections.
  Formulation and evaluation of umbilical cord-derived mesenchymal stem cells exosomes and antioxidants, incorporated in nanoliposomes using microfluidics, for the treatment of solid tumours
  Research Group: Chemistry and Biosciences
  Dr M Najafzadeh, Prof D Anderson, Dr M Isreb
Applications accepted all year round
This project uses the Cord blood Stem Cells from healthy control and the white blood cells of blood cancer patients to investigate the efficacy and genotoxicity of different compounds in them by using various genetic endpoints.
  Identification of colistin resistant gene, mcr-1, in clinical isolated Enterobacteriaceae and characterisation of pathogenicity and virulence of mcr-1 harboured bacterial pathogens
  Research Group: Chemistry and Biosciences
  Dr C Chang, Dr J N Fletcher
Applications accepted all year round
Globally, infectious disease accounts for more than 13 million deaths a year and is one of the main causes of death around the world, predominantly in developing countries.
  Chronic Wounds and Infection - impact on diabetic patients
  Research Group: Centre for Skin Sciences
  Dr M J Thornton, Dr J N Fletcher
Applications accepted all year round
Non-healing chronic wounds present a significant clinical challenge. In Europe, the cost of wound management accounts for 2%–4% of the health care budget and the complications associated with impaired wound healing can have a significant, long-term effect on the morbidity, mortality, and quality of life for patients.
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