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Microbiology PhD Projects, Programs & Scholarships in Leeds

We have 24 Microbiology PhD Projects, Programs & Scholarships in Leeds

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  Nanopore barcoding for detecting metastases in liquid biopsies
  Dr M Castronovo
Application Deadline: 3 January 2020

Funding Type

PhD Type

Liquid biopsy is set to revolutionized the capacity to detect, assess and monitor the evolution of cancer. This technology has a central role to play in precision medicine and population screening approaches, but remains limited by sensitivity and specificity.
  Biodegradable composite materials (Bio-PolyMOFs) for applications in targeted delivery of drugs to improve healthcare and reduce antimicrobial resistance in developing countries and worldwide
  Research Group: Chemistry and Biosciences
  Dr S Nayak, Dr A L Kelly, Dr M Katsikogianni
Applications accepted all year round

Funding Type

PhD Type

Growing antimicrobial resistance (AMR) is one of the major global challenges and is linked to the use of unnecessarily high doses of orally administered antibiotics following medical surgery and infections.
  Employing molecular virology to investigate hepatitis E virus replication (fully-funded PhD)
  Research Group: School of Molecular and Cellular Biology
  Dr M.R. Herod, Prof M Harris
Application Deadline: 27 February 2020

Funding Type

PhD Type

Hepatitis E virus (HEV), is a major causative agent of acute, severe hepatitis. The infection can also be chronic, particular in immunocompromised people, and fatal in pregnant women or those with existing liver diseases.
  Caustic response: understanding plant adaptation to high pH and its application to remediation of alkaline industrial residues.
  Research Group: Centre for Plant Sciences
  Prof A Baker, Prof D I Stewart
Application Deadline: 1 March 2020

Funding Type

PhD Type

Motivation. Around two billion tonnes of alkaline residues are produced globally each year by industrial processes. These residues are frequently stored in waste piles or landfills, and can be an environmental hazard if allowed to generate dust or if rainwater infiltrates the waste (Gomes et al 2016).
  Control and inhibition of virus replication
  Research Group: Astbury Centre for Structural Molecular Biology
  Dr A.K Tuplin
Applications accepted all year round

Funding Type

PhD Type


The Tuplin laboratory utilises a range of cutting-edge approaches to investigate how arboviruses - specificaly Chikungunya, Dengue and Zika viruses - control replication and translation of their genomes through interactions between RNA structures, host cell proteins and non-coding RNA, and the potential of such RNA elements/interactions as novel therapeutic targets.
  River ecosystem responses to glacier loss
  Prof L Brown, Dr D Quincey
Application Deadline: 6 January 2020

Funding Type

PhD Type

Climate change poses a considerable threat to the biodiversity of high altitude ecosystems, with Arctic alpine regions across the world already beginning to show clear responses to warming (Milner et al., 2017).
  MRC DiMeN Doctoral Training Partnership: Role of RNA modifications in virus infection
  Prof A Whitehouse, Prof S Wilson
Application Deadline: 6 January 2020

Funding Type

PhD Type

As an intermediate molecule in the flow of genetic information, RNA offers a critical junction in the cell to regulate many cellular processes that underpin cell biology, development and tissue function.
  MRC DiMeN Doctoral Training Partnership: How does mosquito bite inflammation make virus infection worse?
  Dr C McKimmie, Dr M Lorger, Dr K Shams
Application Deadline: 6 January 2020

Funding Type

PhD Type

The climate crisis is making mosquito-borne virus infections an increasing threat to human health. These viruses, such as those that cause Zika and dengue, are infecting more people and spreading to new countries as the climate warms and globalisation helps mosquitoes spread.
  Computer simulations and fluorescence spectroscopy to study the dynamics of the plant protein Light Harvesting Complex II
  Research Group: BBSRC White Rose DTP
  Dr P.G. Adams, Dr A Kalli
Application Deadline: 6 January 2020

Funding Type

PhD Type

This project will provide insight into the biophysical basis of protein dynamics which are crucial for life but are poorly understood.
  Molecular mechanism of protecting plants from high intensity sunlight: studying Light Harvesting proteins using a combination of advanced electron microscopy and fluorescence methods
  Research Group: BBSRC White Rose DTP
  Dr P.G. Adams, Dr S Muench
Application Deadline: 6 January 2020

Funding Type

PhD Type

Understanding the biophysics of photosynthesis could provide clues to developing the next generation of crops. Light-Harvesting Complex II (LHCII) is the main protein in plants that absorbs solar photons and channels energy to where it is needed.
  Characterisaton of sequence-dependent phosphohistidine phosphatases
  Research Group: BBSRC White Rose DTP
  Dr M E Webb, Prof R.W. Bayliss, Dr M Wright
Application Deadline: 6 January 2020

Funding Type

PhD Type

Phosphohistidine is an ubiquitous modification in bacterial cell signaling, however its function in eukaryotic cells has not been defined.
  Exploiting a novel peptide cyclase to make new antibiotics
  Research Group: BBSRC White Rose DTP
  Dr R Seipke, Dr G.R. Hemsworth, Dr M E Webb
Application Deadline: 6 January 2020

Funding Type

PhD Type

Without new antibiotics the global healthcare system will collapse. Many antibiotics originate from a class of microbial natural products called non-ribosomal peptides, the vast majority of which are cyclic.
  How do RNA structures in the Chikungunya virus genome control virus replication in human and mosquito host cells?
  Research Group: BBSRC White Rose DTP
  Dr A.K Tuplin, Prof A Whitehouse
Application Deadline: 6 January 2020

Funding Type

PhD Type

Chikungunya virus is a mosquito-transmitted arbovirus that re-emerged as an epidemic in 2005 around the Indian Ocean, before spreading across Asia, Africa, Europe and the Americas.
  Role of m6A reader proteins in virus infection
  Research Group: BBSRC White Rose DTP
  Prof A Whitehouse, Dr A.K Tuplin
Application Deadline: 6 January 2020

Funding Type

PhD Type

RNA is an intermediate molecule in the flow of genetic information from DNA to protein. It is a critical junction for the cell to regulate gene expression, through multiple RNA processing events.
  Virus manipulation of host cell micro-RNAs to regulate gene expression
  Research Group: BBSRC White Rose DTP
  Dr A MacDonald, Prof A Whitehouse
Application Deadline: 6 January 2020

Funding Type

PhD Type

micro-RNAs (miRNAs) are abundant endogenous RNAs and emerging evidence suggests they regulate gene expression by multiple processes.
  Development of transdermal protein liposomal delivery system for the treatment of dermatological diseases
  Research Group: Chemistry and Biosciences
  Dr M Najafzadeh, Prof D Anderson
Applications accepted all year round

Funding Type

PhD Type

Biopharmaceuticals have been increasingly used in the treatment of skin diseases. However, due to the poor absorption of peptide and protein through the skin, they are usually delivered through injections.
  Formulation and evaluation of umbilical cord-derived mesenchymal stem cells exosomes and antioxidants, incorporated in nanoliposomes using microfluidics, for the treatment of solid tumours
  Research Group: Chemistry and Biosciences
  Dr M Najafzadeh, Prof D Anderson, Dr M Isreb
Applications accepted all year round

Funding Type

PhD Type

This project uses the Cord blood Stem Cells from healthy control and the white blood cells of blood cancer patients to investigate the efficacy and genotoxicity of different compounds in them by using various genetic endpoints.
  Aldehyde dehydrogenase expression and function in cancer stem cells
  Research Group: Institute of Cancer Therapeutics
  Dr K Pors, Dr A Mardaryev, Prof A Locke
Applications accepted all year round

Funding Type

PhD Type

Aldehyde dehydrogenases (ALDHs) catalyse the oxidation and detoxification of reactive endogenous and exogenous aldehydes into carboxylic acids via NAD+ coupled reduction.
  Chronic Wounds and Infection - impact on diabetic patients
  Research Group: Centre for Skin Sciences
  Dr M J Thornton, Dr J N Fletcher
Applications accepted all year round

Funding Type

PhD Type

Non-healing chronic wounds present a significant clinical challenge. In Europe, the cost of wound management accounts for 2%–4% of the health care budget and the complications associated with impaired wound healing can have a significant, long-term effect on the morbidity, mortality, and quality of life for patients.
  Identification of colistin resistant gene, mcr-1, in clinical isolated Enterobacteriaceae and characterisation of pathogenicity and virulence of mcr-1 harboured bacterial pathogens
  Research Group: Chemistry and Biosciences
  Dr C Chang, Dr J N Fletcher
Applications accepted all year round

Funding Type

PhD Type

Globally, infectious disease accounts for more than 13 million deaths a year and is one of the main causes of death around the world, predominantly in developing countries.
  Synthetic Virology: Development of gene delivery vectors/synthetic vaccines
  Research Group: Astbury Centre for Structural Molecular Biology
  Prof P G Stockley
Applications accepted all year round

Funding Type

PhD Type

There is worldwide interest in exploiting our modern understanding of genomics to target gene expression therapeutically via a variety of mechanisms, such as transgene insertion and CRISPR-Cas gene editing.
  Defining a novel assembly pathway in ssRNA viruses using X-ray footprinting.
  Prof P G Stockley
Applications accepted all year round

Funding Type

PhD Type

Project co-supervised by Prof. Peter Stockley at Leeds and Prof. Reidun Twarock at University of York, as part of the White Rose network "Structural and Mechanistic Biology at the RNA/Ligand Interface".
  Dissecting the molecular mechanisms of antibiotic resistance in bacterial pathogens
  Research Group: Astbury Centre for Structural Molecular Biology
  Dr A O'Neill
Applications accepted all year round

Funding Type

PhD Type

Antibiotics make possible the treatment and cure of life-threatening bacterial infections. Since their introduction in the middle years of the 20th Century, they have added ~10 years to the human lifespan, and have become a cornerstone of modern medicine.
  Towards new antibacterial drugs to treat infections caused by multidrug-resistant bacteria: identification and characterization of novel natural product antibiotics
  Research Group: Astbury Centre for Structural Molecular Biology
  Dr A O'Neill
Applications accepted all year round

Funding Type

PhD Type

The World Health Organization (WHO) has declared antimicrobial drug resistance one of the greatest problems currently facing human health, and the situation is especially grave in the case of infections caused by bacterial pathogens.
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