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Molecular Biology PhD Projects, Programs & Scholarships in Leeds

We have 72 Molecular Biology PhD Projects, Programs & Scholarships in Leeds

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Showing 31 to 40 of 72
  Role of m6A reader proteins in virus infection
  Research Group: BBSRC White Rose DTP
  Prof A Whitehouse, Dr A.K Tuplin
Application Deadline: 6 January 2020

Funding Type

PhD Type

RNA is an intermediate molecule in the flow of genetic information from DNA to protein. It is a critical junction for the cell to regulate gene expression, through multiple RNA processing events.
  Targeting an Achilles heel in bacterial outer membrane biogenesis: Strategies to combat bacterial infection by targeting the periplasmic chaperone SurA
  Research Group: BBSRC White Rose DTP
  Dr A Zhuravleva, Prof S E Radford
Application Deadline: 6 January 2020

Funding Type

PhD Type

In February 2017 the World Health Organisation published a list of antibiotic-resistant "priority pathogens" – a catalogue of 12 families of bacteria that pose the greatest threat to human health.
  Understanding amyloid aggregation mechanisms of alpha- and gamma synuclein in vitro and in vivo
  Research Group: BBSRC White Rose DTP
  Dr P van Oosten-Hawle, Prof S E Radford
Application Deadline: 6 January 2020

Funding Type

PhD Type

A key pathological hallmark of synucleopathies, including Parkinson’s Disease (PD) and Amyotrophic Lateral Sclerosis (ALS), is the formation of cytotoxic alpha-synuclein and gamma-synuclein aggregates respectively, that lead to neuronal cell death.
  Understanding the negative sense RNA intermediate in picornavirus replication
  Research Group: BBSRC White Rose DTP
  Prof N J Stonehouse, Prof D.J. Rowlands
Application Deadline: 6 January 2020

Funding Type

PhD Type

Picornaviruses are responsible for a number of serious diseases, including polio and foot-and–mouth disease. There is an urgent need to develop new strategies to address the continuing issue of picornavirus infection.
  A mechanistic understanding of allosteric regulation of neuronal sodium-activated potassium channels
  Research Group: BBSRC White Rose DTP
  Dr J D Lippiat, Dr S Muench, Dr A Kalli
Application Deadline: 6 January 2020

Funding Type

PhD Type

The sodium-activated potassium channel KNa1.1 (KCNT1, Slack, Slo2.2) is found in neurons and couples sodium influx to excitability.
  Catching BAM in the act: a strategy for novel antibiotics?
  Research Group: BBSRC White Rose DTP
  Dr D Brockwell, Prof S E Radford, Prof N A Ranson
Application Deadline: 6 January 2020

Funding Type

PhD Type

Gram negative bacteria are important pathogens to both humans and livestock responsible for life-threatening opportunistic systemic hospital infections, respiratory and urinary tract infections and gastric ulcers.
  Chemical protein labeling approaches to study TRPC5 channel regulation in adipocytes.
  Research Group: BBSRC White Rose DTP
  Dr R.S. Bon, Prof A J Wilson, Dr P Sukumar
Application Deadline: 6 January 2020

Funding Type

PhD Type

The protein TRPC5 forms homo- and heterotetrameric cation channels that play key roles in cellular signalling and responses to chemical and physical environmental factors, and its implication in human disease (including anxiety disorders, kidney disease and obesity) has resulted in TRPC5 channels emerging as potential therapeutic targets.
  Control of metabolite transport into durable protocells and nanoreactors
  Research Group: BBSRC White Rose DTP
  Dr P Beales, Prof L J C Jeuken, Prof A Goldman
Application Deadline: 6 January 2020

Funding Type

PhD Type

Protocells (or nanoreactors) are seen as a stepping-stone to understanding the origin of life and are being developed to generate novel cell-like biotechnologies.
  Dissecting mechanisms of mRNA translational control by specialised ribosomes and their function during development in Drosophila melanogaster
  Research Group: BBSRC White Rose DTP
  Dr J Aspden, Dr A Bretman, Dr J Fontana
Application Deadline: 6 January 2020

Funding Type

PhD Type

The average cell contains ~10 million ribosomes, comprised of ~80 ribosomal proteins and 4 rRNAs. Until recently it was thought that all ribosomes were the same.
  Elucidating the interactions and transport mechanism of the human chloride/bicarbonate anion exchanger 1
  Research Group: BBSRC White Rose DTP
  Dr A Kalli, Dr C Pliotas
Application Deadline: 6 January 2020

Funding Type

PhD Type

Anion Exchanger 1 (AE1, Band 3, SLC4A1) is responsible for the rapid exchange of bicarbonate and chloride across the red blood cell plasma membrane, a process necessary for efficient respiration.
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