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Molecular Biology PhD Projects, Programs & Scholarships in Leeds

We have 72 Molecular Biology PhD Projects, Programs & Scholarships in Leeds

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  An integrated approach to the study of cellular interactions with amyloid
  Research Group: Astbury Centre for Structural Molecular Biology
  Dr E W Hewitt, Prof S E Radford
Applications accepted all year round

Funding Type

PhD Type

The formation of insoluble amyloid fibrils is associated with a spectrum of human disorders, the amyloidoses, which include Alzheimer’s, Parkinson’s, type 2 diabetes and dialysis related amyloidosis (DRA).
  MRC DiMeN Doctoral Training Partnership: Characterisation of OX40L reverse signalling and its role in the pathogenesis of fibrosis
  Dr N.A. Riobo-Del Galdo, Dr F Del Galdo
Application Deadline: 6 January 2020

Funding Type

PhD Type

Scleroderma (SSc) is a prototypic fibrotic disease, in which an autoimmune mediated injury leads to loss of tissue function through accumulation of extracellular matrix in the skin and internal organs.
  Single-molecule fluorescence-activated cell sorting (smFACS): sorting cells molecule by molecule
  Dr A Ponjavic
Application Deadline: 3 January 2020

Funding Type

PhD Type

This project will develop a novel microfluidic device that can characterise and sort cells, with unprecedented (single-molecule) sensitivity.
  Nanopore barcoding for detecting metastases in liquid biopsies
  Dr M Castronovo
Application Deadline: 3 January 2020

Funding Type

PhD Type

Liquid biopsy is set to revolutionized the capacity to detect, assess and monitor the evolution of cancer. This technology has a central role to play in precision medicine and population screening approaches, but remains limited by sensitivity and specificity.
  Epigenetics and Cancer: Determining how Mistakes in V(D)J Recombination Trigger Leukaemias and Lymphomas
  Dr J Boyes
Application Deadline: 25 January 2020

Funding Type

PhD Type

V(D)J recombination is essential to produce an effective adaptive immune system but since the reaction involves the breakage and rejoining of DNA, it is highly dangerous and errors have long been thought to lead to leukaemias and lymphomas.
  Employing molecular virology to investigate hepatitis E virus replication (fully-funded PhD)
  Research Group: School of Molecular and Cellular Biology
  Dr M.R. Herod, Prof M Harris
Application Deadline: 27 February 2020

Funding Type

PhD Type

Hepatitis E virus (HEV), is a major causative agent of acute, severe hepatitis. The infection can also be chronic, particular in immunocompromised people, and fatal in pregnant women or those with existing liver diseases.
  MRC DiMeN Doctoral Training Partnership: Developing protein tools to target DNA damage response and repair in cancer cells
  Dr Q. Wu, Dr D Tomlinson
Application Deadline: 6 January 2020

Funding Type

PhD Type

DNA damage response (DDR) and repair play critical roles in influencing the efficiency and sensitivity of many cancer treatments.
  MRC DiMeN Doctoral Training Partnership: Understanding proteotoxicity of alpha- and gamma-synuclein in neuronal C. elegans models of neurodegeneration
  Dr P van Oosten-Hawle, Prof S E Radford
Application Deadline: 6 January 2020

Funding Type

PhD Type

Synucleopathies, such as Parkinson’s Disease (PD), are neurodegenerative diseases characterised by the accumulation of alpha-synuclein (asyn) aggregates into Lewy Bodies in neurons, leading to toxicity and cell death.
  MRC DiMeN Doctoral Training Partnership: Individualised heteroclitic peptide immunotherapies for hepatocellular carcinoma
  Dr A Samson, Dr R Tooze
Application Deadline: 6 January 2020

Funding Type

PhD Type

Background. Hepatocellular carcinoma (HCC) is a cancer of unmet need, with 12% five-year survival across all stages, due to late diagnosis and inadequate non-personalised therapies.
  Molecular approaches to modulate antibody receptor signalling in autoimmunity
  Dr J Robinson, Prof A Morgan
Application Deadline: 13 January 2020

Funding Type

PhD Type

Autoantibody-mediated inflammatory diseases are characterised by a proinflammatory feedback loop which leads to the destruction of tissues, prolonged pain, fatigue and subsequent reduction in life quality.
  Caustic response: understanding plant adaptation to high pH and its application to remediation of alkaline industrial residues.
  Research Group: Centre for Plant Sciences
  Prof A Baker, Prof D I Stewart
Application Deadline: 1 March 2020

Funding Type

PhD Type

Motivation. Around two billion tonnes of alkaline residues are produced globally each year by industrial processes. These residues are frequently stored in waste piles or landfills, and can be an environmental hazard if allowed to generate dust or if rainwater infiltrates the waste (Gomes et al 2016).
  Control and inhibition of virus replication
  Research Group: Astbury Centre for Structural Molecular Biology
  Dr A.K Tuplin
Applications accepted all year round

Funding Type

PhD Type


The Tuplin laboratory utilises a range of cutting-edge approaches to investigate how arboviruses - specificaly Chikungunya, Dengue and Zika viruses - control replication and translation of their genomes through interactions between RNA structures, host cell proteins and non-coding RNA, and the potential of such RNA elements/interactions as novel therapeutic targets.
  MRC DiMeN Doctoral Training Partnership: Dissecting the function of long non-coding RNAs during neuronal differentiation and neuronal diseases
  Dr J Aspden, Dr G Hautbergue, Dr J Fontana
Application Deadline: 6 January 2020

Funding Type

PhD Type

Whilst 85% of our genome is transcribed, only 4% is protein-coding. In fact, many non-coding RNAs exist, some of which are similarly processed to mRNAs, termed long non-coding RNAs (lncRNAs).
  MRC DiMeN Doctoral Training Partnership: Role of RNA modifications in virus infection
  Prof A Whitehouse, Prof S Wilson
Application Deadline: 6 January 2020

Funding Type

PhD Type

As an intermediate molecule in the flow of genetic information, RNA offers a critical junction in the cell to regulate many cellular processes that underpin cell biology, development and tissue function.
  MRC DiMeN Doctoral Training Partnership: How does mosquito bite inflammation make virus infection worse?
  Dr C McKimmie, Dr M Lorger, Dr K Shams
Application Deadline: 6 January 2020

Funding Type

PhD Type

The climate crisis is making mosquito-borne virus infections an increasing threat to human health. These viruses, such as those that cause Zika and dengue, are infecting more people and spreading to new countries as the climate warms and globalisation helps mosquitoes spread.
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