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Molecular Biology PhD Projects, Programs & Scholarships in Leeds

We have 41 Molecular Biology PhD Projects, Programs & Scholarships in Leeds

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Showing 1 to 30 of 41
  Cellular mechanisms of detrimental skeletal muscle remodeling induced by cardiac dysfunction
  Dr T.S. Bowen, Dr D Steele
Application Deadline: 14 June 2020

Funding Type

PhD Type

The loss of skeletal muscle mass and strength is a key impairment in many disease states. This occurs in both limb and respiratory muscles and leads to pulmonary complications and severe disability.
  Molecular, biochemical and developmental analysis of root traits for low P adaptation in foxtail millet.
  Prof A Baker, Dr S Kepinski
Applications accepted all year round

Funding Type

PhD Type

Phosphorus is an essential macronutrient for plant growth and cannot be replaced by any other element. It is the second most limiting nutrient after N.
  Epigenetics and Cancer: Determining how Mistakes in V(D)J Recombination Trigger Leukaemias and Lymphomas
  Research Group: School of Molecular and Cellular Biology
  Dr J Boyes
Application Deadline: 1 April 2020

Funding Type

PhD Type

V(D)J recombination is essential to produce an effective adaptive immune system but since the reaction involves the breakage and rejoining of DNA, it is highly dangerous and errors have long been thought to lead to leukaemias and lymphomas.
  Personalised anti-viral immunotherapies for hepatitis B and C virus-associated hepatocellular carcinoma
  Dr A Samson, Dr S Griffin
Application Deadline: 28 February 2020

Funding Type

PhD Type

Hepatocellular carcinoma (HCC) is a cancer of hepatocytes commonly caused by hepatitis B and C virus (HBV/HCV) infections. Only 12% of HCC patients survive for five-years, due to late diagnosis and inadequate non-personalised therapies.
  A mechanistic understanding of allosteric regulation of neuronal sodium-activated potassium channels
  Research Group: BBSRC White Rose DTP
  Dr J D Lippiat, Dr S Muench, Dr A Kalli
Applications accepted all year round

Funding Type

PhD Type

The sodium-activated potassium channel KNa1.1 (KCNT1, Slack, Slo2.2) is found in neurons and couples sodium influx to excitability.
  NC3Rs funded PhD: Affimer – The Next Generation Diagnostic
  Dr C Tiede, Dr D Tomlinson
Application Deadline: 31 January 2020

Funding Type

PhD Type

Animal products are important reagents used in many research settings but little research is being performed to help reduce the number of these reagents in general laboratories.
  Epigenetics and Cancer: Development of Novel Tools to Determine how Aberrant V(D)J Recombination Reactions Cause Leukaemia
  Research Group: School of Molecular and Cellular Biology
  Dr J Boyes
Applications accepted all year round

Funding Type

PhD Type

V(D)J recombination generates a highly diverse set of immunoglobulin and T cell receptor genes to enable vertebrates to fight a vast range of infections.
  Health Opportunity for Patient Empowerment in Gestational Diabetes (HOPE-GDM)
  Research Group: Chemistry and Biosciences
  Prof A M Graham, Prof R Qahwaji, Prof A Locke
Applications accepted all year round

Funding Type

PhD Type

Gestational Diabetes is a temporary condition diagnosed at 24-28 weeks gestation, where the body is unable to maintain normal blood glucose levels due to insulin resistance during pregnancy.
  EPSRC CASE PhD studentship: Novel high-throughput approaches for the rapid analysis of target engagement by mass spectrometry (collaboration with Medicines Discovery Catapult)
  Research Group: Astbury Centre for Structural Molecular Biology
  Prof F. Sobott, Dr J.R. Ault
Application Deadline: 28 February 2020

Funding Type

PhD Type

The ability to provide fast and efficient readouts for drug engagement with targets (proteins and oligonucleotides) is a key driving technology in the biopharma pipeline, e.g.
  Epigenetic therapy using ultrasound-mediated microbubble drug delivery for cancer treatment
  Dr E Valleley, Dr L Coletta
Applications accepted all year round

Funding Type

PhD Type

The project is an interdisciplinary, pre-clinical study that aims to investigate the response of human tumour cells to treatment with epigenetic inhibitors (such as DNA methyltransferase inhibitors), as a potential combination therapy for colorectal cancer (CRC).
  Using next-generation sequencing and CRISPR-Cas9 gene editing to investigate penetrance and phenotypic variation in inherited eye disease
  Dr C Toomes
Applications accepted all year round

Funding Type

PhD Type

Human inherited retinal diseases (IRDs) result from mutations in over 250 different genes, many of them implicated by the Leeds Vision Research Group (eg Panagiotou et al 2017, AJHG 100:960-968; El-Asrag et al 2015, 96:948-54).
  Metabolic reprogramming in cancer: starving tumors of essential nutrients to promote cell death
  Dr S Papa
Applications accepted all year round

Funding Type

PhD Type

All the cells in our bodies are programmed to die. As they get older, our cells accumulate toxic molecules that make them sick. In response, they eventually break down and die, clearing the way for new, healthy cells to grow.
  Novel regulators of +TIP localisation and function
  Dr E E Morrison, Dr S Bell, Dr J Bond
Applications accepted all year round

Funding Type

PhD Type

Microtubules (MTs) are a key cytoskeletal network in all eukaryotic cells. MTs grow and shrink primarily through the addition or loss of tubulin heterodimers from their plus end.
  Developing pluripotent stem cell models of inherited retinal diseases
  Prof C A Johnson
Applications accepted all year round

Funding Type

PhD Type

Background. Inherited retinal dystrophies are a leading cause of blindness and visual loss in the UK working age population. However, despite the widespread diagnostic use of next-generation sequencing, a molecular genetic diagnosis is unavailable for many patients world-wide.
  How human teeth form and how that process fails in the inherited condition amelogenesis imperfecta
  Prof C Inglehearn
Applications accepted all year round

Funding Type

PhD Type

Amelogenesis is the process of enamel formation and is essential for the development of functional teeth. Amelogenesis imperfecta (AI) is a failure of that process.
  Genome and transcriptome sequencing and functional analysis to find new mutation types in patients with inherited blindness
  Prof C Inglehearn
Applications accepted all year round

Funding Type

PhD Type

Human inherited retinal dystrophies (IRDs) result from mutations in over 200 different genes, many of them first implicated by the Leeds Vision Research Group (eg Panagiotou E et al 2017, AJHG 100:960-968; El-Asrag M et al 2015, 96:948-54).
  Enhancing Oncolytic Virus-induced Immunotherapy using Eicosapentaenoic Acid (EPA)
  Dr F Errington-Mais, Dr MA Volpato
Applications accepted all year round

Funding Type

PhD Type

Breast cancer is the most commonly diagnosed cancer in women with triple-negative breast cancer (TNBC) having the worst prognosis, highest death rate and lowest overall survival.
  Exploring the mitotic functions of ASPM in human brain size regulation
  Dr J Bond, Dr E E Morrison, Prof M Peckham
Applications accepted all year round

Funding Type

PhD Type

The increase in relative brain size is one of the most striking events in human evolution. To determine how human brain size is normally regulated we have investigated the cause of autosomal recessive primary microcephaly (MCPH), a congenital disorder of reduced brain size and associated mental retardation.
  The functional characterization of the tumour suppressor gene CSMD1 in breast cancer
  Dr S Bell
Applications accepted all year round

Funding Type

PhD Type

CUB and Sushi multiple domains protein 1 (CSMD1) maps to 8p23, a region deleted in many cancers including breast cancer. Our previous work has established that CSMD1 is an independent prognostic marker in ductal breast cancer, with reduced expression associated with high tumour grade and poor survival1.
  Identification and functional characterisation of BRIT1/MCPH1 synthetic lethal genes to treat breast and ovarian cancer
  Dr S Bell, Prof C A Johnson
Applications accepted all year round

Funding Type

PhD Type

Women who have undergone surgery for breast and ovarian cancer often have additional chemotherapy to kill residual cancer cells and prevent recurrence.
  Genetic studies of corneal endothelial dystrophies and development of alternative treatment options
  Dr M Ali
Applications accepted all year round

Funding Type

PhD Type

The cornea is the protective front part of the eye that provides most of the eyes focusing power. The endothelium is a single-cell layer on the inside of the cornea that maintains fluid balance and is required for corneal transparency.
  Oncogenic mechanisms causing malignant transformation of lymphoid cells
  Prof U Klein
Applications accepted all year round

Funding Type

PhD Type

Cancers of B cells and plasma cells, lymphomas and multiple myeloma, can be very aggressive, and often the cancer rapidly reoccurs after standard therapy.
  Dissecting the molecular mechanisms of antibiotic resistance in bacterial pathogens
  Research Group: Astbury Centre for Structural Molecular Biology
  Dr A O'Neill
Applications accepted all year round

Funding Type

PhD Type

Antibiotics make possible the treatment and cure of life-threatening bacterial infections. Since their introduction in the middle years of the 20th Century, they have added ~10 years to the human lifespan, and have become a cornerstone of modern medicine.
  Towards new antibacterial drugs to treat infections caused by multidrug-resistant bacteria: identification and characterization of novel natural product antibiotics
  Research Group: Astbury Centre for Structural Molecular Biology
  Dr A O'Neill
Applications accepted all year round

Funding Type

PhD Type

The World Health Organization (WHO) has declared antimicrobial drug resistance one of the greatest problems currently facing human health, and the situation is especially grave in the case of infections caused by bacterial pathogens.
  Using massively-paralleled sequencing to find the cause of inherited conditions that affect the front of the eye
  Dr M Ali, Prof C Inglehearn
Applications accepted all year round

Funding Type

PhD Type

Eye diseases are a common cause of human disability and many of them are inherited. These include congenital as well as adult-onset conditions and diseases of ageing, and may involve abnormalities at the back of the eye or the anterior eye structures.
  Effect of nanoparticles on cellular conditions in lymphocytes and germ cells in vitro
  Research Group: Chemistry and Biosciences
  Prof D Anderson, Dr M Najafzadeh
Applications accepted all year round

Funding Type

PhD Type

The use of metals such as silver (Ag), gold (Au) and copper (Cu) as nanoparticles (NPs) and other chemicals such as Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) (Najafzadeh et al., 2016) in medical and lifestyle applications has exponentially increased in recent years, yet little is still known about their impact on DNA and RNA in somatic as well as in germ cells (Habas et al 2018).
  Biomarkers of Genotoxic and Reprotoxic Effects after chemical exposure in vitro in human cells
  Research Group: Chemistry and Biosciences
  Prof D Anderson, Dr M Najafzadeh
Applications accepted all year round

Funding Type

PhD Type

In human monitoring procedures, measurements obtained from endpoints to determine genetic damage are sometimes referred to as biomarkers.
  An improved C. elegans model of Alzheimer’s Disease to monitor neuronal signalling activity
  Research Group: Astbury Centre for Structural Molecular Biology
  Dr P van Oosten-Hawle, Prof N Cohen, Dr S Clapcote
Application Deadline: 31 January 2020

Funding Type

PhD Type

Alzheimer’s Disease (AD) is one of the most common form of neurodegenerative diseases known today, affecting approximately 50 million people worldwide.
  An integrated approach to the study of cellular interactions with amyloid
  Research Group: Astbury Centre for Structural Molecular Biology
  Dr E W Hewitt, Prof S E Radford
Applications accepted all year round

Funding Type

PhD Type

The formation of insoluble amyloid fibrils is associated with a spectrum of human disorders, the amyloidoses, which include Alzheimer’s, Parkinson’s, type 2 diabetes and dialysis related amyloidosis (DRA).
  Employing molecular virology to investigate hepatitis E virus replication (fully-funded PhD)
  Research Group: School of Molecular and Cellular Biology
  Dr M.R. Herod, Prof M Harris
Application Deadline: 27 February 2020

Funding Type

PhD Type

Hepatitis E virus (HEV), is a major causative agent of acute, severe hepatitis. The infection can also be chronic, particular in immunocompromised people, and fatal in pregnant women or those with existing liver diseases.
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