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Leeds×
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Pharmaceutical / Medicinal Chemistry PhD Projects, Programs & Scholarships in Leeds

We have 15 Pharmaceutical / Medicinal Chemistry PhD Projects, Programs & Scholarships in Leeds

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Showing 1 to 10 of 15
  Rational design and production of glyco-peptidic inhibitors of pathogens’ adhesion to host cells.
  Research Group: Astbury Centre for Structural Molecular Biology
  Dr E Paci, Prof W B Turnbull
Application Deadline: 30 September 2019
The ability of protein molecules to stick to cells is crucial for life and disease. The project is based on a novel concept to design adhesive molecules based on multivalence and entropic stabilisation.
  Pre-clinical testing of new therapeutic treatments for cystic kidney disease
  Dr S Bell, Prof C A Johnson
Applications accepted all year round
The primary cilium on the ventral surface of most vertebrate cells acts as an “antennae” that receives and transduces chemo- and mechanosensory signals.
  Identification and functional characterisation of BRIT1/MCPH1 synthetic lethal genes to treat breast and ovarian cancer
  Dr S Bell, Prof C A Johnson
Applications accepted all year round
Women who have undergone surgery for breast and ovarian cancer often have additional chemotherapy to kill residual cancer cells and prevent recurrence.
  Tetrazines as Traceless Carriers for Polar Drugs
  Research Group: Medicines Development and Pharmaceutical Sciences
  Dr R Wheelhouse, Prof P Loadman
Applications accepted all year round
A recent invention in Bradford has identified a new carrier molecule that reduces the polarity of polar drugs.
  Studies on impact of co-former selection on physicochemical properties of crystalline active pharmaceutical complexes
  Research Group: Medicines Development and Pharmaceutical Sciences
  Dr K Paluch
Applications accepted all year round
Studies on the enhanced bioavailability profile of existing antibiotics are essential, considering growing bacterial resistance and increasing demand on cost-effective and safe antibacterial treatments.
  Quantitative structure/skin-permeation relationships (QSPeRs); an investigation of the relevance of parameters determined with biomembrane-mimicking systems for the predictability of drug partitioning into skin
  Research Group: Medicines Development and Pharmaceutical Sciences
  Dr X Liu, Prof D J Tobin
Applications accepted all year round
The transdermal route has many advantages over other routes for the delivery of drugs with systemic activity. These include the ease of use (and withdrawal in the occurrence of side-effects), avoidance of first-pass metabolism, and improved patient compliance.
  Design, synthesis and evaluation of MMP-activated anti-cancer prodrugs
  Research Group: Institute of Cancer Therapeutics
  Dr R Falconer, Prof P Loadman
Applications accepted all year round
Matrix metalloproteinases (MMPs) are a family of endoproteases that are overexpressed in tumours and play crucial roles in many tumourigenic processes, not least tumour invasion and angiogenesis.
  Design, synthesis and evaluation of novel polysialyltransferase inhibitors as anti- metastatic agents
  Research Group: Institute of Cancer Therapeutics
  Dr R Falconer, Dr S Shnyder
Applications accepted all year round
Polysialic acid plays an essential role in neuronal development, but by adulthood is absent from the human body. Its biosynthesis is regulated by two polysialyltransferases (polySTs).
  Ion channel gating kinetics and structure implication for drug delivery
  Research Group: Chemistry and Biosciences
  Dr L Shang, Dr Z Hughes
Applications accepted all year round
Ion channels are proteins which sit in the membrane of every cell in the body and control the flow of positively charged ions such as sodium and potassium into and out of the cell.
  Directed Co-Crystallisation of Pharmaceuticals: developing a predictive method for co-crystallisation
  Research Group: Chemistry and Biosciences
  Dr C Seaton
Applications accepted all year round
In this project, we propose to use a combination of computational and experimental techniques to develop a predictive method for co-crystallisation.
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