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Pharmacology / Toxicology PhD Projects, Programs & Scholarships in Leeds

We have 27 Pharmacology / Toxicology PhD Projects, Programs & Scholarships in Leeds

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  Biodegradable composite materials (Bio-PolyMOFs) for applications in targeted delivery of drugs to improve healthcare and reduce antimicrobial resistance in developing countries and worldwide
  Research Group: Chemistry and Biosciences
  Dr S Nayak, Dr A L Kelly, Dr M Katsikogianni
Applications accepted all year round

Funding Type

PhD Type

Growing antimicrobial resistance (AMR) is one of the major global challenges and is linked to the use of unnecessarily high doses of orally administered antibiotics following medical surgery and infections.
  Impact of RhoA deregulation on smooth muscle cell phenotypic dysfunction in Type 2 diabetes
  Research Group: Chemistry and Biosciences
  Dr K Riches-Suman
Applications accepted all year round

Funding Type

PhD Type

Type 2 diabetes (T2D) is an escalating healthcare burden. It inflicts significant physical and emotional distress on patients and their carers, and treatment of T2D and its complications accounts for ~10% of the entire NHS budget.
  Investigating the mechanism of action of dual antiangiogenic/ antineoplastic drugs using organotypic co-culture of fibroblasts and endothelial cells
  Research Group: Institute of Cancer Therapeutics
  Dr J Elies Gomez, Dr K Pors
Applications accepted all year round

Funding Type

PhD Type

An important feature of many types of cancer is the ability to develop abnormal angiogenesis (blood vessel formation); this allows cancer cells to gain access to nutrients and favours metastasis.
  Design, synthesis and evaluation of novel polysialyltransferase inhibitors as anti- metastatic agents
  Research Group: Institute of Cancer Therapeutics
  Dr R Falconer, Dr S Shnyder
Applications accepted all year round

Funding Type

PhD Type

Polysialic acid plays an essential role in neuronal development, but by adulthood is absent from the human body. Its biosynthesis is regulated by two polysialyltransferases (polySTs).
  Polysialyltransferases as a target in metastatic cancer
  Research Group: Institute of Cancer Therapeutics
  Dr R Falconer, Dr S Shnyder
Applications accepted all year round

Funding Type

PhD Type

Polysialic acid plays an essential role in neuronal development, but by adulthood is absent from the human body. Its biosynthesis is regulated by two polysialyltransferases.
  Design, synthesis and evaluation of protease-activated anti-cancer prodrugs
  Research Group: Institute of Cancer Therapeutics
  Dr R Falconer, Prof P Loadman
Applications accepted all year round

Funding Type

PhD Type

Matrix metalloproteinases (MMPs) are a family of endoproteases that are overexpressed in tumours and play crucial roles in many tumourigenic processes, not least tumour invasion and angiogenesis.
  Discovery of chemical and biological tools to probe hypoxic solid tumours
  Research Group: Institute of Cancer Therapeutics
  Dr K Pors, Dr J Elies Gomez
Applications accepted all year round

Funding Type

PhD Type

A major challenge in cancer therapy is to develop therapeutic agents that selectively target tumour cells. One avenue towards the development of more selective cancer therapies is to exploit the unique physiological properties of solid tumours using prodrug approaches.
  Aldehyde dehydrogenase expression and function in cancer stem cells
  Research Group: Institute of Cancer Therapeutics
  Dr K Pors, Dr A Mardaryev, Prof A Locke
Applications accepted all year round

Funding Type

PhD Type

Aldehyde dehydrogenases (ALDHs) catalyse the oxidation and detoxification of reactive endogenous and exogenous aldehydes into carboxylic acids via NAD+ coupled reduction.
  Development of heterocyclic pharmacophores using diversity-oriented synthesis
  Research Group: Institute of Cancer Therapeutics
  Dr K Pors, Prof L Patterson
Applications accepted all year round

Funding Type

PhD Type

Diversity-oriented synthesis (DOS) is a modern chemical tool, which aims to synthesise small molecules that cover new chemical space with the possibility of finding unexplored biological targets or pathways that may be important for disease progression.
  New strategies in integrin antagonism
  Research Group: Institute of Cancer Therapeutics
  Dr H Sheldrake
Applications accepted all year round

Funding Type

PhD Type

The integrins are a family of transmembrane receptors which mediate cell-cell and cell-ECM adhesion, and signalling across the cell membrane involved in pathways controlling cell migration, proliferation, differentiation, cell survival and apoptosis.
  Endosomal Sorting Complex Required for Transport (ESCRT): Investigation of the role in acquired drug resistance in colon cancer
  Research Group: Institute of Cancer Therapeutics
  Dr S Shnyder, Dr S Kantamneni
Applications accepted all year round

Funding Type

PhD Type

Despite treatment advances, one of the most common cancers, colorectal cancer (CRC), still has a 45% mortality rate, and one of the major problems is the build-up of resistance to cancer drugs during treatment (‘acquired resistance’) such that over time the drugs stop working.
  Biofilm disruption as an initial step in a novel strategy for treatment of chronic wounds based on multi-functional liposomal nanocarriers
  Research Group: Medicines Development and Pharmaceutical Sciences
  Dr X Liu, Dr S Shnyder
Applications accepted all year round

Funding Type

PhD Type

The cost to the NHS of caring for patients with chronic wounds is conservatively estimated to be £4.5-5.7bn/year, or around 4% of the total expenditure on health.
  ERK5 MAPK signalling in Alzheimer’s disease
  Research Group: Pharmacology and Experimental Therapeutics
  Dr J Muller, Dr S Kantamneni
Applications accepted all year round

Funding Type

PhD Type

Neurodegenerative diseases have devastating effects on individuals’ lives and our society, with no effective treatments available.
  Therapeutic resolution of pulmonary arterial hypertension (PAH) by natural products
  Research Group: Pharmacology and Experimental Therapeutics
  Dr T Nasim, Prof C Wright
Applications accepted all year round

Funding Type

PhD Type

Pulmonary arterial hypertension (PAH) is a devastating cardiovascular disorder which, if left untreated, leads to heart failure and death.
  Re-purposing established drugs for the resolution of pulmonary arterial hypertension (PAH)
  Research Group: Pharmacology and Experimental Therapeutics
  Dr T Nasim
Applications accepted all year round

Funding Type

PhD Type

Pulmonary arterial hypertension (PAH) is a devastating cardiovascular disorder which, if left untreated, leads to heart failure and death.
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