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Pharmacology / Toxicology PhD Projects, Programs & Scholarships in Leeds

We have 23 Pharmacology / Toxicology PhD Projects, Programs & Scholarships in Leeds

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  New strategies in integrin antagonism
  Research Group: Institute of Cancer Therapeutics
  Dr H Sheldrake
Applications accepted all year round

Funding Type

PhD Type

The integrins are a family of transmembrane receptors which mediate cell-cell and cell-ECM adhesion, and signalling across the cell membrane involved in pathways controlling cell migration, proliferation, differentiation, cell survival and apoptosis.
  Design, synthesis and evaluation of protease-activated anti-cancer prodrugs
  Research Group: Institute of Cancer Therapeutics
  Dr R Falconer, Prof P Loadman
Applications accepted all year round

Funding Type

PhD Type

Matrix metalloproteinases (MMPs) are a family of endoproteases that are overexpressed in tumours and play crucial roles in many tumourigenic processes, not least tumour invasion and angiogenesis.
  Design, synthesis and evaluation of novel polysialyltransferase inhibitors as anti- metastatic agents
  Research Group: Institute of Cancer Therapeutics
  Dr R Falconer, Dr S Shnyder
Applications accepted all year round

Funding Type

PhD Type

Polysialic acid plays an essential role in neuronal development, but by adulthood is absent from the human body. Its biosynthesis is regulated by two polysialyltransferases (polySTs).
  Polysialyltransferases as a target in metastatic cancer
  Research Group: Institute of Cancer Therapeutics
  Dr R Falconer, Dr S Shnyder
Applications accepted all year round

Funding Type

PhD Type

Polysialic acid plays an essential role in neuronal development, but by adulthood is absent from the human body. Its biosynthesis is regulated by two polysialyltransferases.
  ERK5 MAPK signalling in Alzheimer’s disease
  Research Group: Pharmacology and Experimental Therapeutics
  Dr J Muller, Dr S Kantamneni
Applications accepted all year round

Funding Type

PhD Type

Neurodegenerative diseases have devastating effects on individuals’ lives and our society, with no effective treatments available.
  Therapeutic resolution of Myodysplastic Syndrome (MDS)
  Research Group: Pharmacology and Experimental Therapeutics
  Dr T Nasim, Dr K Pors
Applications accepted all year round

Funding Type

PhD Type

Myelodysplastic syndromes (MDS) are the most common adult myeloid malignancy in the UK and it has been estimated that around 8,000 and 40,000 new cases are diagnosed each year in the UK and USA, respectively.
  Impact of RhoA deregulation on smooth muscle cell phenotypic dysfunction in Type 2 diabetes
  Research Group: Chemistry and Biosciences
  Dr K Riches-Suman
Applications accepted all year round

Funding Type

PhD Type

Type 2 diabetes (T2D) is an escalating healthcare burden. It inflicts significant physical and emotional distress on patients and their carers, and treatment of T2D and its complications accounts for ~10% of the entire NHS budget.
  Activity based proteomic probes for profiling CYP2W1 in cancer tissues
  Research Group: Institute of Cancer Therapeutics
  Dr C Sutton, Dr K Pors
Applications accepted all year round

Funding Type

PhD Type

Cytochromes P450 (CYPs) are a superfamily of mixed function oxidases of which CYP1-4 subfamily members are unique in their ability to oxidise drugs.
  Determining brain glycosylation in ageing and Alzheimer’s disease
  Research Group: Pharmacology and Experimental Therapeutics
  Dr R Williamson, Dr C Sutton
Applications accepted all year round

Funding Type

PhD Type

Increasing age is associated with lower levels of cognitive performance; concomitant with this is a decrease in brain glucose metabolism.
  Development of transdermal protein liposomal delivery system for the treatment of dermatological diseases
  Research Group: Chemistry and Biosciences
  Dr M Najafzadeh, Prof D Anderson
Applications accepted all year round

Funding Type

PhD Type

Biopharmaceuticals have been increasingly used in the treatment of skin diseases. However, due to the poor absorption of peptide and protein through the skin, they are usually delivered through injections.
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