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Pharmacology / Toxicology PhD Projects, Programs & Scholarships in Leeds

We have 31 Pharmacology / Toxicology PhD Projects, Programs & Scholarships in Leeds

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Leeds  United Kingdom

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We have 31 Pharmacology / Toxicology PhD Projects, Programs & Scholarships in Leeds

Evaluation of potential therapeutics in a mouse model of KCNT1-related epilepsy

  Research Group: School of Biomedical Sciences
Human mutations in the KCNT1 gene, which encodes a sodium-activated potassium channel, results in severe and drug-resistant childhood epilepsy. Read more

Targeting protein acetylation to reduce microglia activation in neurodegenerative disorders

Recently, inhibitors of histone deacetylase enzymes (HDACs) have been identified as having potential therapeutic value for a range of neuronal disorders including Alzheimer’s disease, dementia and stroke [1, 2]. Read more

PhD in Continuous Manufacturing and Advanced Crystallisation

The EPSRC CMAC Future Manufacturing Research Hub is offering 13 fully-funded industry-sponsored PhD studentships for research projects in the wider area of continuous manufacturing and advanced crystallisation. Read more

Pharmaceutical cocrystallisation for improved medicines

  Research Group: Centre for Pharmaceutical Engineering Science
Active pharmaceutical ingredients (APIs) are frequently delivered to the patients in the solid-state formulation. Numerous tons of tablets are produced daily worldwide by pharmaceutical industry. Read more

Aldehyde dehydrogenase expression and function in cancer stem cells

  Research Group: Institute of Cancer Therapeutics
Aldehyde dehydrogenases (ALDHs) catalyse the oxidation and detoxification of reactive endogenous and exogenous aldehydes into carboxylic acids via NAD+ coupled reduction. Read more

Identifying cognitive and biochemical changes underlying lifestyle risk factors for dementia

  Research Group: Pharmacology and Experimental Therapeutics
Dementia describes a group of age-associated conditions of which cognitive decline is a major feature. Alzheimer’s disease (AD) is the most common cause of dementia and is characterised by the onset of a gradual cognitive decline. Read more

Formulation and biopharmaceutical characterisation of novel pro-antibiotics for improved oral permeability

  Research Group: Medicines Development and Pharmaceutical Sciences
This project is focused on the formulation, synthesis, and biopharmaceutical characterisation of novel pro-antibiotics for improved oral bioavailability. Read more

Development of a personalized therapy for pulmonary arterial hypertension (PAH)

  Research Group: Pharmacology and Experimental Therapeutics
Pulmonary arterial hypertension (PAH) is a devastating cardiovascular disorder which, if left untreated, leads to heart failure and death. Read more

Therapeutic resolution of coronavirus (COVID-19) diseases by natural products

  Research Group: Pharmacology and Experimental Therapeutics
Coronavirus now labelled as Covid-19 has become a global pandemic affecting around 200 countries. Currently neither any cure nor any vaccine for Covid-19 has been established. Read more

Using ex-vivo genetic systems as models to detect genetic susceptibility to co-morbidities in Covid 19 infection, and to test specific anti-inflammatory / antiviral drugs in Covid 19 infection

  Research Group: Chemistry and Biosciences
Research has shown that certain individuals are more susceptible to SARS-CoV-2. Approximately, 20–51% of COVID-19 patients presented with a least one co-morbidity on admission, with diabetes (10–20%) hypertension (10–15%) and other cardiovascular and cerebrovascular diseases (7–40%) being most prevalent. Read more

Impact of normal and premature ageing on human macro- and microvasculature

  Research Group: Centre for Skin Sciences
The global population is growing, with the number of births consistently higher than the number of deaths. This is because people are living for longer, due at least in part to improved lifestyle and healthcare provision. Read more

The role of UV exposure and novel compounds on the immunogenicity and genotoxicity of skin cancer

  Research Group: Chemistry and Biosciences
The major aims of this project are to investigate the effect of UV in the development of different skin cancers compared to spontaneously regressing precancerous lesion, keratoacanthoma; and the effect of a novel compounds such as the structurally modified retinoic acid in the treatment of skin cancers and other cutaneous lesions. Read more

Design, synthesis and evaluation of novel polysialyltransferase inhibitors as anti- metastatic agents

  Research Group: Institute of Cancer Therapeutics
Polysialic acid plays an essential role in neuronal development, but by adulthood is absent from the human body. Its biosynthesis is regulated by two polysialyltransferases (polySTs). Read more

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