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We have 30 Pharmacology PhD Projects, Programmes & Scholarships in Leeds

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Leeds  United Kingdom

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Pharmacology PhD Projects, Programmes & Scholarships in Leeds

We have 30 Pharmacology PhD Projects, Programmes & Scholarships in Leeds

Polysialyltransferases as a target in metastatic cancer

  Research Group: Institute of Cancer Therapeutics
Polysialic acid plays an essential role in neuronal development, but by adulthood is absent from the human body. Its biosynthesis is regulated by two polysialyltransferases. Read more

Design, synthesis and evaluation of protease-activated anti-cancer prodrugs

  Research Group: Institute of Cancer Therapeutics
Matrix metalloproteinases (MMPs) are a family of endoproteases that are overexpressed in tumours and play crucial roles in many tumourigenic processes, not least tumour invasion and angiogenesis. Read more

Design, synthesis and evaluation of novel polysialyltransferase inhibitors as anti- metastatic agents

  Research Group: Institute of Cancer Therapeutics
Polysialic acid plays an essential role in neuronal development, but by adulthood is absent from the human body. Its biosynthesis is regulated by two polysialyltransferases (polySTs). Read more

Therapeutic resolution of pulmonary arterial hypertension (PAH) by natural products

  Research Group: Pharmacology and Experimental Therapeutics
Pulmonary arterial hypertension (PAH) is a devastating cardiovascular disorder which, if left untreated, leads to heart failure and death. Read more

A bifunctional prodrug to overcome acquired oxaliplatin drug resistance in colorectal cancer

  Research Group: Institute of Cancer Therapeutics
This is one of two new fully funded PhD studentships in the Institute of Cancer Therapeutics Doctoral Training Centre (ICT-DTC) at the University of Bradford. Read more

Investigating molecular determinants of cellular fate driven by air pollutants

Air pollution is a critical global issue with severe consequences for the environment, economy, and human health. 99% of the world’s population lives in areas where air pollution exceeds WHO guidelines, leading to accelerated ageing, increased mortality, and decreased health span [1,2,3]. Read more

Endosomal Sorting Complex Required for Transport (ESCRT): Investigation of the role in acquired drug resistance in colon cancer

  Research Group: Institute of Cancer Therapeutics
Despite treatment advances, one of the most common cancers, colorectal cancer (CRC), still has a 45% mortality rate, and one of the major problems is the build-up of resistance to cancer drugs during treatment (‘acquired resistance’) such that over time the drugs stop working. Read more

Pharmacokinetics Guided Natural Products Exploration for Drug Discovery, Development, Delivery and Therapy

  Research Group: Institute of Cancer Therapeutics
Natural products have emerged as a key standard in novel and safe delivery of anticancer bioactive compounds. Apart from their ease of administration and delivery, natural/phytochemicals still face several hurdles, due to their physiochemical and pharmacokinetic properties. Read more

ERK5 MAPK signalling in Alzheimer’s disease

  Research Group: Pharmacology and Experimental Therapeutics
Neurodegenerative diseases have devastating effects on individuals’ lives and our society, with no effective treatments available. Read more

Investigation of novel PARP7-targeting agents for the treatment of cancer

PARP7, an ADP-ribosyltransferase, modulates protein function by adding an ADP-ribose moiety to target proteins. It is involved in many physiological and pathophysiological processes such as neural development, maintenance of stem cells, immunity, xenobiotic metabolism, immunity and cancers. Read more

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