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We have 19 Structural Biology PhD Projects, Programmes & Scholarships in Leeds

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Biological Sciences

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Leeds  United Kingdom

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Structural Biology PhD Projects, Programmes & Scholarships in Leeds

We have 19 Structural Biology PhD Projects, Programmes & Scholarships in Leeds

Machine Learning and Molecular Modelling in Mass Spectrometry

This PhD project will harness the power of computational modelling and machine learning (A.I.) to analyse data obtained by mass spectrometry experiments and predict structural characteristics of biomolecules and their interactions. Read more

Epigenetics and Cancer: Determining how Mistakes in V(D)J Recombination Trigger Leukaemias and Lymphomas

V(D)J recombination is essential to produce an effective adaptive immune system but since the reaction involves breakage and rejoining of DNA, it is highly dangerous and errors have long been thought to lead to leukaemias and lymphomas. Read more

Control and inhibition of virus replication

The Tuplin laboratory utilises a range of cutting-edge approaches to investigate how arboviruses - specifically Chikungunya, Dengue and Zika viruses - control replication and translation of their genomes through interactions between RNA structures, host cell proteins and non-coding RNA, and the potential of such RNA elements/interactions as novel therapeutic targets. Read more

Using cryo-electron microscopy to study large protein complexes that mediate the female post-mating response

In many animals, male seminal fluid alters female physiology and post-mating behaviour to ensure paternity of the offspring. However, how seminal fluid components elicit these post-mating responses is poorly understood. Read more

The role of ubiquitin-modifying enzymes in angiogenesis

The School of Molecular & Cellular Biology invites applications from prospective postgraduate researchers who wish to commence study for a PhD in the academic year 2024/25. Read more

DogDots: a new approach to labelling of membrane proteins for tomographic analysis

Membrane proteins are crucial to cellular function, such as recognition of – and interaction with – the extracellular environment and neighbouring cells, and controlling membrane dynamics, cellular signalling and transport of molecules and ions across membranes. Read more

Seeing inside the brain of Alzheimer’s disease by cryoET

The aim of this PhD project is to determine the in situ 3D molecular structures associated with AD to understand disease mechanisms and molecular pathways that can lead to the rational design of a mechanism-based therapy. Read more

Developing live cell crosslinking mass spectrometry methods to investigate cardiac myosin folding and disease

Cardiac myosin is the molecular motor responsible for muscle contraction in the heart. Its correct production and folding are critical to maintaining normal heart function and mutations within the beta cardiac myosin heavy chain gene cause inherited heart disease. Read more

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