We have 110 PhD Projects, Programmes & Scholarships in Leicester

Ever wondered how nature maintains balance of gene expression between sex chromosomes? Well, the 46th chromosome of XX females, the second X, has to be switched off. Read more

Supervisors: Dr Y Markaki, Dr T Schalch

23 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Molecular dissection of horizontal gene transfer mechanisms in mycobacteria

University of Leicester Molecular and Cell Biology

A fully funded PhD position is available within the lab of Dr Abhinav KV at Leicester Institute of Structural and Chemical Biology (LISCB), University of Leicester, UK to carry out structural studies on large macromolecular machines that undertake horizontal gene transfer (HGT) in mycobacteria. Read more

Supervisors: Dr A Koyamangalath Vadakkepat , Prof J Schwabe

29 April 2024 PhD Research Project Funded PhD Project (Students Worldwide)

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Evaluating the impact of genotoxic aldehyde stress in premature ageing

University of Leicester Department of Chemistry

Aldehydes are highly reactive chemicals that are common pollutants and human metabolites. However, the vast majority of aldehydes’ biological functions are unknown. Read more

Supervisors: Dr R Hopkinson, Dr K Tanaka

23 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Natural products in bacterial physiology and chemical interaction

University of Leicester Department of Genetics and Genome Biology

Microbial natural products have diverse chemical structures and bioactivities, which range from cell-cell signalling, nutrient acquisition, antifungal and antibacterial activity to stress resistance (1). Read more

Supervisors: Dr C Jenul, Prof D Jones

23 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Nuclear and transcriptional dysregulations during cellular senescence

University of Leicester Molecular and Cell Biology

Cellular senescence, which is characterised by a proliferation arrest, is a driver of ageing (1). Several stresses can induce cellular senescence, including persistent DNA damage, telomere dysfunction, and oncogene activation. Read more

Supervisors: Dr MT Tellier, Dr Y Markaki

23 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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The Role of Reactive Sulfur Species in the Ageing Heart

University of Leicester Molecular and Cell Biology

Second Supervisor. Prof Melanie Madhani, University of Birmingham. Background . Ageing is a natural and complex biological process that involves the gradual deterioration of cells, tissues, and organ systems over time, thus leading to an increased susceptibility to diseases and mortality. Read more

Supervisor: Dr C Switzer

23 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Using measures of eye movements and EEG to understand effects of cognitive ageing on reading

University of Leicester School of Psychology and Vision Sciences

Healthy ageing is associated with reductions in visual and cognitive abilities that are required for many activities of daily life (e.g., reading, navigation, object-finding). Read more

Supervisors: Prof K Paterson, Dr A Pagán

23 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Molecular level understanding of Mycobacterium tuberculosis

University of Leicester Department of Respiratory Sciences

Mycobacterium tuberculosis has evolved to survive and replicate inside macrophages. The project will investigate the molecular mechanisms underpinning adaptation to this specialised intracellular niche. Read more

Supervisors: Dr H O'Hare, Dr N Garton

23 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Understanding centrosome function in the human airway

University of Leicester Molecular and Cell Biology

Breathing sustains our life and is also important for our quality of life. Inside the lung, billions of hair-like structures called cilia beat a million times a day to promote a process called mucociliary clearance. Read more

Supervisors: Dr R Mahen, Prof EH Hollox

23 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Investigating the role of SUMOylation in meiotic recombination and chromosome segregation in Arabidopsis

University of Leicester Department of Genetics and Genome Biology

Research Group: Midlands Integrative Biosciences Training Partnership (MIBTP)

Post-translational modifications of proteins such as phosphorylation, methylation and acetylation have been extensively studied in eukaryotes and now the Small Ubiquitin modifier (SUMO) is gaining attention for its importance in fundamental biological roles. Read more

Supervisors: Dr J Higgins, Dr D Guttery

23 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Unlocking the genetic potential of barley by modulating recombination

University of Leicester Department of Genetics and Genome Biology

Barley is a major worldwide crop used for malting and animal feed. However, breeding new varieties is constrained by the frequency of genetic crossovers (1-3 crossovers per chromosome pair) and their distribution (biased towards the chromosome ends) that underpin crop improvement1,2. Read more

Supervisors: Dr J Higgins, Dr D Guttery

23 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Enhancing meiotic recombination in wheat by modulating RECQ helicases

University of Leicester Department of Genetics and Genome Biology

Wheat accounts for 20% of the calories and protein consumed by humans and is the largest crop in the UK, but yields have plateaued and are susceptible to decline due to extreme weather conditions. Read more

Supervisors: Dr J Higgins, Dr D Guttery

23 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Exploring the role of tryptophan metabolism in schizophrenia pathogenesis

University of Leicester Department of Genetics and Genome Biology

L-kynurenine (KYN) and kynurenic acid (KYNA) are metabolites of the kynurenine pathway (KP) of tryptophan degradation and have been found to be increased in the brains of patients with schizophrenia. Read more

Supervisor: Prof F Giorgini

23 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Structural-guided PROTAC targeting of BMX to modulate apoptotic sensitivity in disease

University of Leicester Molecular and Cell Biology

What determines at the molecular level whether a cell lives or dies? Regulation of the cellular life–death switch is essential in healthy cells for normal foetal development and for the clearance of damaged cells. Read more

Supervisors: Dr JF Fox, Dr JH Hodgkinson

23 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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The Evolution of Vision in Mosquitoes

University of Leicester Department of Genetics and Genome Biology

Background . Due to their capacity to transmit viruses such as Zika and parasites like Plasmodium (the causative agent of malaria), mosquitos are regarded by the World Health Organization as one of the most lethal organisms on our planet (WHO | Global vector control response 2017–2030, 2020). Read more

Supervisors: Dr R Feuda, Dr E Rosato, Dr B Warren

23 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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We have 110 PhD Projects, Programmes & Scholarships in Leicester

PhD Projects, Programmes & Scholarships in Leicester

We have 110 PhD Projects, Programmes & Scholarships in Leicester

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