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Bioinformatics PhD Projects, Programs & Scholarships in Liverpool

We have 21 Bioinformatics PhD Projects, Programs & Scholarships in Liverpool

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Showing 1 to 15 of 21
  Severe infection in coronavirus and haemorrhagic fever viruses
  Prof J Hiscox, Dr T Fletcher
Application Deadline: 19 June 2020

Funding Type

PhD Type

In the past twenty years we have seen several outbreaks of global concern caused by coronaviruses and haemorrhagic fevers. These include, SARS, MERS, COVID-19 and Ebola virus.
  Shape, shear, search & strife; mathematical models of bacteria
  Dr R Bearon, Dr M Horsburgh, Dr B Vasiev
Application Deadline: 31 May 2020

Funding Type

PhD Type

Applications will close as soon as a suitable candidate has been found.
  Working at the intersection of protein bioinformatics and structural biology: exploiting protein structural ensembles to facilitate structure solution from X-ray crystallography and cryo-EM
  Prof D J Rigden, Dr R Keegan
Applications accepted all year round

Funding Type

PhD Type

Structural biology contributes enormously to advances across all areas of biology. X-ray crystallography is the major structure determination workhorse but cryo-EM studies are increasingly popular and powerful.
  Molecular analysis of the dynamic sulfotyrosine proteome
  Prof C E Eyers, Prof P Eyers, Dr A R Jones
Applications accepted all year round

Funding Type

PhD Type

The survival of an organism depends upon the ability of different cell types to communicate with each other by assembling the correct complexes of proteins at the correct time in the correct place.
  Exploiting advanced methods for protein structure prediction
  Prof D J Rigden, Dr R Keegan
Applications accepted all year round

Funding Type

PhD Type

Protein structural information is crucial for an understanding of protein function and evolution. Currently, there is only experimental data for a tiny fraction of the protein universe.
  Investigating the molecular mechanisms and consequences of ANP aggregation for cardiovascular disease; a computational and experimental approach
  Dr J Madine, Prof D J Rigden, Dr M Winn
Applications accepted all year round

Funding Type

PhD Type

Atrial natriuretic peptide (ANP) is a cardiovascular hormone synthesised and secreted by myocytes in the atrial wall where it regulates atrial blood volume and vasodilation.
  The genomics of sperm killing gene drive
  Dr T Price, Prof G Hurst, Prof S Paterson
Applications accepted all year round

Funding Type

PhD Type

Many selfish genetic elements spread rapidly through populations by killing gametes that do not carry them. This fascinating phenomena also has practical applications.
  Deep learning approaches to discover new roles for non-canonical protein modifications in cancer
  Prof C E Eyers, Prof A Jones
Applications accepted all year round

Funding Type

PhD Type

Abnormal protein phosphorylation is strongly associated with cancer aetiology. Considerable efforts have been undertaken to profile phosphorylation signalling networks acting through serine, threonine and tyrosine residues.
  Characterization and functional analysis of a novel cancer-associated gene
  Dr JP de Magalhaes
Applications accepted all year round

Funding Type

PhD Type

This opportunity will remain open until the position has been filled. In order to identify new candidate cancer-related genes, our lab developed a bioinformatics “guilt-by-association” method to identify and rank genes that are co-expressed with known cancer-related genes.
  Analysis of Heparin Binding Proteins and the Supramolecular Structure of Extracellular Matrix
  Prof D G Fernig, Prof C E Eyers
Applications accepted all year round

Funding Type

PhD Type

Changes in heparan sulfate structure and location have long been associated with Alzheimer’s disease, but the functional significance of this has remained elusive.
  Investigating the mechanisms driving meiotic gene re-expression in cancer
  Dr U McClurg, Dr W Wei Tee
Applications accepted all year round

Funding Type

PhD Type

Meiosis is a specialised type of cell division which involves genome rearrangements. Many of the genes involved in meiotic homologous recombination are meiosis-specific however, they also constitute a latent toolbox of chromosome remodelling and recombination factors, which can be exploited by cancer cells.
  Exploring the role of meiotic proteins in cancer
  Dr U McClurg
Applications accepted all year round

Funding Type

PhD Type

Cancer is one of the main causes of death worldwide. The main challenge is the development of treatments specifically targeting cancers without killing healthy cells.
  Multi-omics investigations for enhanced understanding of NF-κB mediated drug resistance
  Prof R Goodacre, Prof N Perkins, Prof C E Eyers, Dr A R Jones
Application Deadline: 1 June 2020

Funding Type

PhD Type

We have an established system that can be used to investigate the role of NF-κB signalling in the cancer cell response to DNA replication stress and have generated cell lines which are resistant to treatment with a highly selective and specific CHK1 inhibitor (CCT244747).
  Single-cell proteomic analysis of host-factor cleavage during norovirus infection
  Dr E Emmott, Dr M Iturriza
Applications accepted all year round

Funding Type

PhD Type

Human norovirus is a major human pathogen, and the causative agent behind ‘winter vomiting disease’. Typically, infection is self-limited, causing diarrhoea and vomiting lasting from 24-72 hours.
  Moving the tipping point: the decision to anticoagulate patients with atrial fibrillation
  Dr RW Wilkinson, Dr IS Siekmann, Prof G Lip, Prof P Lisboa
Applications accepted all year round

Funding Type

PhD Type

Atrial fibrillation (AF) is a heart condition that causes an irregular and often abnormally fast heart rate, and leads to a high risk of stroke and death.
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