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Cell Biology / Development PhD Projects, Programs & Scholarships in Liverpool

We have 18 Cell Biology / Development PhD Projects, Programs & Scholarships in Liverpool

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Showing 1 to 18 of 18
  Exploring the role of meiotic proteins in cancer
  Dr U McClurg
Applications accepted all year round

Funding Type

PhD Type

Cancer is one of the main causes of death worldwide. The main challenge is the development of treatments specifically targeting cancers without killing healthy cells.
  Molecular analysis of the dynamic sulfotyrosine proteome
  Prof C E Eyers, Prof P Eyers, Dr A R Jones
Applications accepted all year round

Funding Type

PhD Type

The survival of an organism depends upon the ability of different cell types to communicate with each other by assembling the correct complexes of proteins at the correct time in the correct place.
  Single-cell proteomic analysis of host-factor cleavage during norovirus infection
  Dr E Emmott, Dr M Iturriza
Applications accepted all year round

Funding Type

PhD Type

Human norovirus is a major human pathogen, and the causative agent behind ‘winter vomiting disease’. Typically, infection is self-limited, causing diarrhoea and vomiting lasting from 24-72 hours.
  Defining the role of NF-𝜅B during embryonic stem cell differentiation
  Dr D Turner, Prof A McArdle
Applications accepted all year round

Funding Type

PhD Type

Mouse Embryonic stem cells (mESCs) are a useful system to probe early development. They can be maintained in a pluripotent state in culture, and differentiated using well-defined protocols to all tissue types of the embryo proper.
  Mechanistic mathematical/computational modelling of the PAR polarity network
  Dr N Savage, Dr J Rodriguez
Applications accepted all year round

Funding Type

PhD Type

Cell function is dependent on cell shape. For example, dendritic spine morphology changes from filopodia, which are thought to be searching structures, to mushroom shaped once a potential synaptic connection is found, increasing the postsynaptic surface.
  The Biology of Parasitism in Parasitic Nematodes
  Prof M Viney
Applications accepted all year round

Funding Type

PhD Type

We work on the biology of parasitic nematode worms, particularly Strongyloides spp. The recent, detailed characterisation of the Strongyloides genome (Hunt et al.
  The Eco-Immunology of Wild Mice
  Prof M Viney
Applications accepted all year round

Funding Type

PhD Type

The immune responses that wild animals make contribute to their fitness, but what those immune responses are – and how they differ from those of laboratory animals – is hardly known.
  The effect of low protein diet on the development of the musculoskeletal system
  Dr A Vasilaki, Prof MJ Jackson, Dr I Kanakis, Dr K Whysall
Applications accepted all year round

Funding Type

PhD Type

Age-related sarcopenia is characterised by reduction in the number of myofibres and motor neurons and an additional weakening of the remaining fibres, causing reduction in muscle mass and function.
  Methionine adenosyltransferases in disease and regulation of gene expression
  Dr S Antonyuk, Prof S Hasnain
Applications accepted all year round

Funding Type

PhD Type

Transmethylation, the transfer of a methyl group from one molecule to another, is a fundamental chemical reaction that plays a central role in important biological processes such as gene expression, cell growth and apoptosis.
  Targeting ageing: Genes and compounds with pro-longevity, health-preserving effects
  Dr JP de Magalhaes
Applications accepted all year round

Funding Type

PhD Type

Ageing is arguably the major biomedical challenge of the 21st century. In model organisms, the process of ageing can be manipulated by both genetic manipulations and dietary interventions.
  Uncovering the mechanisms of cryoprotectant toxicity and improving cryopreservation protocols
  Dr JP de Magalhaes
Applications accepted all year round

Funding Type

PhD Type

Cryopreservation is the process of placing cells, organs or even whole organisms at low temperatures so that they remain in a state of suspended animation and function is preserved.
  Mitochondrial protein folding and diseases
  Prof L-Y Lian, Dr D Criddle
Applications accepted all year round

Funding Type

PhD Type

Many diseases, including cancer and neurological disease, stem from mitochondrial dysfunctions often triggered by sudden elevation of agents such as calcium and reactive oxygen species.
  LaNts in wound repair, stem cell activation and squamous cell carcinoma
  Dr K Hamill
Applications accepted all year round

Funding Type

PhD Type

The Laminin N terminus proteins (LaNts) are a relatively unstudied protein family that are related to netrins and laminins. To date there are only two publications and one preprint about the LaNt proteins in the literature which means there is a massive potential to do novel, ground breaking research in this area.
  LaNts and laminins in breast cancer
  Dr K Hamill
Applications accepted all year round

Funding Type

PhD Type

The laminins are a family of proteins that make up part of specialised regions of extracellular matrix termed basement membranes.
  Taking control of cancer-associated splicing switches
  Dr K Hamill
Applications accepted all year round

Funding Type

PhD Type

In cancer, numerous changes to protein expression occur. Some of these are the result of changes to gene transcription or mRNA degradation rates, however, it has increasingly apparent that changes to alternative splicing profile are a key driver of cancer progression.
  Multicellular Cell Differentiation Model: The control of root hair patterning in Aspergillus thaliana
  Dr N Savage, Dr A Bishopp
Applications accepted all year round

Funding Type

PhD Type

Plants absorb water and nutrients from the soil through hairs that grow along their roots. As such, being able to manipulate root hair numbers may be advantageous to the development of crops more resistant to drought and nutrient deficient soils.
  The molecular mechanisms underlying reproductive organ photosynthesis
  Dr D O'Maoileidigh
Applications accepted all year round

Funding Type

PhD Type

Increasing crop yields while decreasing environmental impacts of agriculture is one of the major challenges facing modern society.
  Tissue Engineering of Functional Cardiac Tissue using a Newly Characterised Cardiac Stem Cell Population
  Dr R Oldershaw, Dr R Barrett-Jolley, Dr A P Meeson
Applications accepted all year round

Funding Type

PhD Type

We will develop a novel route to create and test stem cell-derived engineered cardiac tissue for use in heart infarct repair or in vitro drug screening.
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