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We have 29 Cell Biology PhD Projects, Programmes & Scholarships for Self-funded Students in Liverpool
Cell Biology PhD Projects, Programmes & Scholarships for Self-funded Students in Liverpool
We have 29 Cell Biology PhD Projects, Programmes & Scholarships for Self-funded Students in Liverpool
Determining metabolic reprogramming events in stem cells in response to inflammatory disease phenotype
Mesenchymal stem cells (MSCs) are responsible for the repair of damaged tissue following injury and disease as well as moderating innate and adaptive immune responses and regulation of self-tolerance and tissue homeostasis. Read more
Biological pathways supporting the formation and function of chromatin (Scholarship)
Every cell in our body contains the same DNA yet each cell expresses a different set of genes. These changes in gene expression are heavily influenced by histone proteins, their role in packaging DNA into chromatin and the “epigenetic” information they carry. Read more
Probing Death Decisions from Morphogen Gradient Fields
Morphogen gradient scaling is one of the hottest fields in developmental biology at the moment. Scaling is fundamental, explaining how the machinery that controls pattern formation in development (the morphogens) can adapt, so that organs of different sizes show morphological structures which are proportioned. Read more
Uncovering the role of RARɣ in mouse embryonic development using gastruloids
The three retinoic acid receptors (RAR), RARα, RARβ, RARɣ, are transcription factors that control gene expression and cell fate following their activation by all-trans retinoic acid (ATRA), the active metabolite of vitamin A. Read more
Investigating the cellular functions of Trappc9 in brain development and microcephaly
This PhD project will investigate the cellular functions of the Trafficking protein particle complex subunit 9 (Trappc9) and its roles in brain development. Read more
Investigating the impact of galectin-ligand interaction on cancer cell resistance to chemotherapeutic treatment
Galectins are multifunctional carbohydrate-binding proteins that are expressed by many types of human cells. Changes of galectin expression commonly occur in cancer (e.g. Read more
Chromatin regulation of oncogenic transcription and replication stress: mechanism and functional implications in acute myeloid leukemia
This project focuses on the molecular mechanisms promoting acute myeloid leukaemia (AML), a disease of great unmet need. AML is an aggressive blood and bone marrow cancer characterized by abnormal proliferation and differentiation of myeloid cells. Read more
Regulation of mitosis through centrosomal calcium signals and coupled actin dynamics
Background. Cell division and mitosis are at the centre of development and often dysregulated in diseases associated with ageing, like cancer. Read more
Improving chemical and immunological assessment to drive safer development of the new breed of drugs: PROTACS
Proteolysis-targeting chimeras (PROTACs) are a new class of drugs with immense potential across multiple therapeutic areas in drug development. Read more
Elucidation of a new pathological mechanism for brittle bone disease
University of Liverpool
Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology
The incidence of the brittle bone disease osteogenesis imperfecta (OI) is estimated to be around 1 in 10,000 individuals. The phenotypic spectrum of OI ranges from mild to perinatal lethal and includes extra-skeletal connective tissue manifestations. Read more
Exploring the roles of dynamic atypical protein phosphorylation in cancer
Proteins are extensively regulated by dynamic, often reversible post-translational modifications (PTMs). This process allows cells to respond rapidly to environmental factors, be that e.g. Read more
Extracellular matrix regulation of extracellular vesicles
Extracellular vesicles are a group of lipid particles secreted by cells as a means to regulate the behaviour of the tissue. Their importance is being increasingly appreciated in many different contexts including tissue regeneration, developmental processes, inflammation and cancer progression. Read more
Uncovering the mechanochemical signalling inputs that drive gastruloid axial patterning
How the early mammalian embryo converts a mass of identical cells in an organism with multiple axes of symmetry (anteroposterior, dorsoventral, mediolateral) is a critical question in developmental biology. Read more
Preclinical testing of collagen synthesis inhibitors for fibrotic disease
University of Liverpool
Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology
Fibrotic disease is characterised by an excessive accumulation of collagen within tissues, which then impedes tissue function. Organ fibrosis specifically kidney fibrosis, liver fibrosis, cardiac fibrosis and lung fibrosis have limited treatment options, pose a huge clinical burden and are life-limiting diseases. Read more
Cardiovascular and Neuromuscular Functions around the Clock: Harnessing Protective Endogenous Mechanisms towards Smarter Design of Novel Therapies and Interventions
Optimal tissue and organ is essential for long-term health and quality of life. One such important regulator within the body is related to circadian rhythms, which control ~24h cycles in many physiological processes such as sleep/wake cycles, physical activity/rest cycles, drug metabolism and hormones. Read more
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