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We have 31 Cell Biology PhD Projects, Programmes & Scholarships for Self-funded Students in Liverpool
Cell Biology PhD Projects, Programmes & Scholarships for Self-funded Students in Liverpool
We have 31 Cell Biology PhD Projects, Programmes & Scholarships for Self-funded Students in Liverpool
Investigating the role of neutrophil-mediated tissue damage in a model of lupus nephritis
Systemic lupus erythematosus (SLE) is a rare autoimmune disease that affects around 5 million people worldwide. It disproportionately affects women and is incurable. Read more
Identifying age-related extracellular microenvironment in dental tissues
University of Liverpool
Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology
Periodontal disease is the sixth most globally prevalent age-related disease and a leading cause of tooth loss, significantly impacting quality of life and healthy ageing. Read more
Alterations in reparative dentinogenesis with ageing, gender and genetic predisposition
Dental pulp exposure caused by tooth decay or injury can lead to life-threatening infections. Following injury, reparative dentinogenesis serves a vital purpose through the accelerated generation of tertiary dentine, comprising mineral and type I collagen. Read more
Urokinase-plasminogen activator as a target to block osteoarthritic cartilage destruction
Osteoarthritis (OA) is one of the major causes of disability globally, which is particularly significant in an ageing population. Read more
RNA therapy development for inherited eye diseases
Applications are welcomed for self-funded students to pursue a PhD in RNA therapeutics. The PhD project will use short activating RNAs to specifically increase target gene expression in inherited or acquired eye disease. Read more
Investigating the role of Aquaporins in age related diseases
Physical frailty, with its associated immobility and disability, is a major factor limiting independence among older people. A key contributor to frailty is a decline in muscle mass and strength (sarcopenia) and the burden of sarcopenia is substantial, with a cost to the NHS of ~£2.5bn/pa. Read more
Preclinical testing of collagen synthesis inhibitors for fibrotic disease
Fibrotic disease is characterised by an excessive accumulation of collagen within tissues, which then impedes tissue function. Organ fibrosis specifically kidney fibrosis, liver fibrosis, cardiac fibrosis and lung fibrosis have limited treatment options, pose a huge clinical burden and are life-limiting diseases. Read more
Elucidation of a new pathological mechanism for brittle bone disease
The incidence of the brittle bone disease osteogenesis imperfecta (OI) is estimated to be around 1 in 10,000 individuals. The phenotypic spectrum of OI ranges from mild to perinatal lethal and includes extra-skeletal connective tissue manifestations. Read more
Investigating the regulation of neutrophil gene expression by intracellular signalling and small non-coding RNAs
Immune-mediated inflammatory diseases (IMID) such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) affect millions of people worldwide and cause debilitating and disabling musculoskeletal disease. Read more
Using pre-clinical models of disease to define new targets to slow joint degeneration in osteoarthritis
The main overall aim of this project is to understand mechanisms of joint degeneration during osteoarthritis progression in order to define new targets for therapy. Read more
Control of bone shape and function by the extracellular matrix Fibrillin-1
Bones are tightly regulated structures that remodel their structure to adapt to changes in their mechanical environment. With ageing, this mechanical response is often dampened, leading to bone loss and weakness. Read more
Investigating the role of oxidative metabolites in joint destruction in osteoarthritis
We are seeking a motivated researcher to work on a pioneering project investigating the role of oxidative stress in alkaptonuria (AKU) and associated conditions. Read more
The effect of low protein diet on the development of the neuromuscular system
Age-related sarcopenia is characterised by reduction in the number of myofibres and motor neurons and an additional weakening of the remaining fibres, causing reduction in muscle mass and function. Read more
Determination of the non-coding RNAs in the knee joint tissues of dogs at differing risk to cranial cruciate ligament rupture.
University of Liverpool
Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology
Background. The cranial cruciate ligment (CCL) is the most frequently damaged ligament of the canine knee joint following injuries and age-related ligament breakdown, leading to the development of osteoarthritis (OA). Read more
Hepatic Models to personalise cancer chemotherapy
The most commonly used chemotherapy regimens for colorectal cancer with liver metastases are oxaliplatin combined with 5-FU and leucovorin, i.e. Read more