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We have 26 Molecular Biology PhD Projects, Programmes & Scholarships in Liverpool
Molecular Biology PhD Projects, Programmes & Scholarships in Liverpool
We have 26 Molecular Biology PhD Projects, Programmes & Scholarships in Liverpool
Biological pathways supporting the formation and function of chromatin (Scholarship)
Every cell in our body contains the same DNA yet each cell expresses a different set of genes. These changes in gene expression are heavily influenced by histone proteins, their role in packaging DNA into chromatin and the “epigenetic” information they carry. Read more
Development of enzymes for the sustainable synthesis of pharmaceutically relevant amides under aqueous conditions.
A PhD studentship is available to work on a multidisciplinary project led by Professor Andrew Carnell on the discovery and development of enzymes for application in the sustainable synthesis pharmaceutically relevant amides. Read more
Chromatin regulation of oncogenic transcription and replication stress: mechanism and functional implications in acute myeloid leukemia
This project focuses on the molecular mechanisms promoting acute myeloid leukaemia (AML), a disease of great unmet need. AML is an aggressive blood and bone marrow cancer characterized by abnormal proliferation and differentiation of myeloid cells. Read more
Probing Death Decisions from Morphogen Gradient Fields
Morphogen gradient scaling is one of the hottest fields in developmental biology at the moment. Scaling is fundamental, explaining how the machinery that controls pattern formation in development (the morphogens) can adapt, so that organs of different sizes show morphological structures which are proportioned. Read more
Investigating the cellular functions of Trappc9 in brain development and microcephaly
This PhD project will investigate the cellular functions of the Trafficking protein particle complex subunit 9 (Trappc9) and its roles in brain development. Read more
Determining metabolic reprogramming events in stem cells in response to inflammatory disease phenotype
Mesenchymal stem cells (MSCs) are responsible for the repair of damaged tissue following injury and disease as well as moderating innate and adaptive immune responses and regulation of self-tolerance and tissue homeostasis. Read more
Cardiovascular and Neuromuscular Functions around the Clock: Harnessing Protective Endogenous Mechanisms towards Smarter Design of Novel Therapies and Interventions
Optimal tissue and organ is essential for long-term health and quality of life. One such important regulator within the body is related to circadian rhythms, which control ~24h cycles in many physiological processes such as sleep/wake cycles, physical activity/rest cycles, drug metabolism and hormones. Read more
Vaccine development for important spirochaetal diseases of cattle.
*Bovine digital dermatitis (DD) is a severe, infectious, foot skin disease affecting cattle worldwide. This disease causes severe pain resulting in ruminant lameness and impacts animal welfare. Read more
Identifying age-related extracellular microenvironment in dental tissues
University of Liverpool
Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology
Periodontal disease is the sixth most globally prevalent age-related disease and a leading cause of tooth loss, significantly impacting quality of life and healthy ageing. Read more
Establishing the biomarker potential of extracellular RNA structure in chronic diseases
Extracellular RNAs have emerged as potentially important components of intracellular communication mechanisms. Often encapsulated within vesicular structures, the roles that they perform in are still not fully established. Read more
Why do cancers cells re-express meiotic SYCP1 protein?
The aim of meiosis is to generate gametes by recombining the chromosomes and reducing the genome from diploid to haploid. However, in mitosis haploid genome and recombination have catastrophic, oncogenic outcomes. Read more
Uncovering the role of RARɣ in mouse embryonic development using gastruloids
The three retinoic acid receptors (RAR), RARα, RARβ, RARɣ, are transcription factors that control gene expression and cell fate following their activation by all-trans retinoic acid (ATRA), the active metabolite of vitamin A. Read more
Engineering more water-use efficient crops: functional genomics of CO2 fixation during Crassulacean acid metabolism
The world is getting hotter and drier due to climate change, and the human population is growing rapidly. Furthermore, it has been predicted that we will need to increase crop yields by 50 - 70 % by 2050 in order to feed the predicted 9 - 10 billion people. Read more
Extracellular matrix regulation of extracellular vesicles
Extracellular vesicles are a group of lipid particles secreted by cells as a means to regulate the behaviour of the tissue. Their importance is being increasingly appreciated in many different contexts including tissue regeneration, developmental processes, inflammation and cancer progression. Read more
Investigating the impact of galectin-ligand interaction on cancer cell resistance to chemotherapeutic treatment
Galectins are multifunctional carbohydrate-binding proteins that are expressed by many types of human cells. Changes of galectin expression commonly occur in cancer (e.g. Read more
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