Morphogen gradient scaling is one of the hottest fields in developmental biology at the moment. Scaling is fundamental, explaining how the machinery that controls pattern formation in development (the morphogens) can adapt, so that organs of different sizes show morphological structures which are proportioned. Read more
Applications are welcomed for self-funded students to pursue a PhD in RNA therapeutics. The PhD project will use short activating RNAs to specifically increase target gene expression in inherited or acquired eye disease. Read more
Extracellular vesicles are a group of lipid particles secreted by cells as a means to regulate the behaviour of the tissue. Their importance is being increasingly appreciated in many different contexts including tissue regeneration, developmental processes, inflammation and cancer progression. Read more
Extracellular RNAs have emerged as potentially important components of intracellular communication mechanisms. Often encapsulated within vesicular structures, the roles that they perform in are still not fully established. Read more
The main overall aim of this project is to understand mechanisms of joint degeneration during osteoarthritis progression in order to define new targets for therapy. Read more
Background. The cranial cruciate ligment (CCL) is the most frequently damaged ligament of the canine knee joint following injuries and age-related ligament breakdown, leading to the development of osteoarthritis (OA). Read more
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