This PhD project aims to develop innovative bioinformatics platforms for deep mining of multi-omics datasets, to extract clinically meaningful information in order to identify new ‘druggable’ biological targets associated with tissue inflammation and fibrosis that are crucial for the development of targeted therapeutics for common diseases (lung, cardiovascular and renal).
The studentship aims at development of a manufacturing process for pilot scale synthesis of nano-sized molecularly imprinted polymers (nanoMIPs) for therapeutic studies.
Ageing is a biological process that affects all living creatures. Despite the scientific advances of the past decades, the mechanisms that lead to ageing in humans are not fully understood.
Loughborough University is a top-ten rated university in England for research intensity (REF2014) and an outstanding 66% of the work of Loughborough’s academic staff who were eligible to be submitted to the REF was judged as ‘world-leading’ or ‘internationally excellent’, compared to a national average figure of 43%.
The ability to regulate the transcriptional activity of protein coding genes is one of the most fundamental processes of life. The transcriptional potential of a gene is directly related to its chromatin context, which in turn, is influenced by the covalent modification of its core histone components.
One of the key pathological characteristics of IgA nephropathy (IgAN) is the maladaptive and chronic accumulation and remodelling of the extracellular matrix (ECM) in affected glomeruli leading to fibrosis and progressive loss of function.