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We have 68 Biochemistry PhD Projects, Programmes & Scholarships in Manchester
Biochemistry PhD Projects, Programmes & Scholarships in Manchester
We have 68 Biochemistry PhD Projects, Programmes & Scholarships in Manchester
(BBSRC NWD) Harnessing organic catalysts for precision interaction mapping in ubiquitin-like systems
This PhD project focuses on the development and application of innovative tools to achieve high-resolution mapping of protein-protein interactions (PPIs) within ubiquitin-like protein (UBL) systems, addressing a critical gap in understanding cellular signalling. Read more
Identification and structural analysis of transient interactions in supra-molecular complexes involved in protein synthesis
The aim of this project is to understand the dynamic interactions in the mechanism and control of protein synthesis in eukaryotic cells at the molecular level using hydrogen-deuterium exchange mass spectrometry (HDX-MS), and particularly the role of the eukaryotic translation initiation factors eIF2, eIF5 and eIF2B[1,2]. Read more
Novel method development and applications in Electron Paramagnetic Resonance
A 4-year PhD studentship in novel method development and applications in Electron Paramagnetic Resonance (EPR) is available in the group of Dr Alice Bowen. Read more
(BBSRC NWD) Uncovering the roles of collagen VI in normal breast tissue stiffness, signalling and proliferation
The steroid hormones estrogen and progesterone are fundamental for normal breast development, promoting epithelial cell proliferation. Read more
(BBSRC NWD) Protein engineering and assembly of mini-collagens
Collagen VI is a human connective tissue protein found at the interface of cells with the surrounding extracellular matrix with an essential role in maintaining tissue tensile strength. Read more
Chaperones and the response to protein misfolding stress
Misfolded proteins are usually refolded to their functional conformations or degraded by quality control mechanisms. When misfolded proteins evade quality control, they form aggregates that are sequestered to specific sites within cells. Read more
Using genomic technologies to determine circadian regulation of psoriasis (Sep 25 entry)
Circadian control of inflammation is emerging as an exciting field, with immediate translation potential. Psoriasis represents a model of immune-mediated inflammation in which the pathology is accessible and amenable to serial investigation. Read more
(BBSRC NWD) Environmental C-F/C-Cl remediation by heme mono-oxygenases and peroxidases.
A PhD studentship is available for an outstanding and ambitious chemist to undertake research in the field of green chemistry, biotechnology, and metalloenzyme mechanism in a collaborative project between Drs Jack Rowbotham, Sam de Visser and Derren Heyes (Manchester Institute of Biotechnology) at the University of Manchester. Read more
(BBSRC NWD CASE) Investigating the metabolic changes in human skin bacteria as a function of human sebum composition
Project background. This is a DTP CASE project is a collaboration between University of Manchester and University of Liverpool academics as well as Unilever. Read more
(BBSRC NWD) Developing biomaterials to engineer how cancer cells sense force to regulate gene expression
Overview . This project seeks to develop material engineering approaches to model and understand the mechanisms by which force is transmitted from the extracellular microenvironment into the nucleus to regulate gene expression. . Read more
(BBSRC NWD) Structural analysis of protein molecular machines and transient states involved in regulation of protein synthesis
We aim to determine the molecular basis of key steps in protein synthesis and its control in eukaryotes, using advanced structural biology methods. Regulation of the initiation steps for protein synthesis in eukaryotes is central to the integrated stress response, a fundamental survival mechanism present in all eukaryotes. Read more
(BBSRC NWD) The role of La-related proteins at colliding and frameshifting ribosomes during oxidative stress
Oxygen is critical for life, but is highly reactive and we know excess oxygen radicals damage all cellular components including DNA, RNA and proteins. Read more
(BBSRC NWD) Investigating how dynamic signalling cytonemes enable cell-cell signalling in developing neural tissues
During embryonic nervous system development, neural stem cells must balance decisions between proliferation to allow growth, and differentiation, to generate neurons. Read more
Protein engineering and assembly of mini-collagens
Collagen VI is a human connective tissue protein found at the interface of cells with their surrounding extracellular matrix in almost all mammalian tissues. Read more
Defining the role of glycation in extracellular matrix damage in ageing and diabetic skin
In skin, long-lived extracellular matrix (ECM) components in the dermis undergo a form of ageing where damage is accumulated to their protein structures by mechanisms such as glycation, photo-oxidation and protease cleavage, leading to profound changes in tissue architecture and function. Read more