Noise pollution is a serious problem in many aspects of modern society. Although many materials exist that can provide mechanisms for sound absorption, particularly in the higher frequency ranges, compact low-frequency noise attenuation and absorption remains a significant challenge.
Clinical prediction models (CPMs), which predict the occurrence of an event of interest given what is known about an individual, could enable a personalised and preventative approach to healthcare.
Pathogens have developed intricate ways to overcome the host’s immune system. In this proposal we will study the direct interaction of macrophages with the important food-borne bacterial pathogen Listeria monocytogenes that causes significant human morbidity and mortality.
In the past years the use of virtual screening or computer-based screening of compound libraries against selected targets has expanded exponentially the boundaries of drug discovery.
Dr A Murray, Prof G Parker, Prof A Herrick, Dr M Dickinson
Applications accepted all year round
Systemic sclerosis (SSc) is a microvascular autoimmune disease that causes lack of blood flow and scarring and thickening of skin and tissues within internal organs.
Background – Enzyme engineering strategies, supported by computational and molecular modelling to maximise speed and efficiency, has been shown to be a powerful tool for (semi-) rational design of enzymes.1,2 We will evaluate protein mobility/dynamics, docking/binding of substrates and calculation of free energy barriers for catalysis.
. The White Rose Social Sciences Doctoral Training Partnership (WRDTP), accredited by the Economic and Social Research Council in 2016, is a collaboration across the social sciences at the Universities of Leeds, Sheffield, York, Bradford, Sheffield Hallam, Hull, and Manchester Metropolitan.
The protein secretory pathway comprises a series of membranous compartments and transport vesicles that cells use to synthesise, post-translationally modify, and move proteins for delivery to the plasma membrane or for secretion to the extracellular matrix.
Drosophila germline stem cells (GSCs) are a premier model for understanding stem cell regulation. Upon division, one GSC daughter remains a stem cell, whereas the other differentiates into a cystoblast (CB).