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Bioinformatics PhD Projects, Programs & Scholarships in Manchester

We have 27 Bioinformatics PhD Projects, Programs & Scholarships in Manchester

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Showing 1 to 10 of 27
  Acoustic properties of nanofibre composites
  Prof W J Parnell
Application Deadline: 16 September 2019
Noise pollution is a serious problem in many aspects of modern society. Although many materials exist that can provide mechanisms for sound absorption, particularly in the higher frequency ranges, compact low-frequency noise attenuation and absorption remains a significant challenge.
  Statistical Learning and Adaptive Observation in Clinical Prediction: Methodology and Applications
  Dr G P Martin, Dr N Peek, Prof I Buchan
Application Deadline: 28 February 2019
Clinical prediction models (CPMs), which predict the occurrence of an event of interest given what is known about an individual, could enable a personalised and preventative approach to healthcare.
  (WIS) How food-borne Listeria monocytogenes overcomes the host defence mechanisms at the single cell level?
  Dr P Paszek, Prof I Roberts
Application Deadline: 28 February 2019
Pathogens have developed intricate ways to overcome the host’s immune system. In this proposal we will study the direct interaction of macrophages with the important food-borne bacterial pathogen Listeria monocytogenes that causes significant human morbidity and mortality.
  Exploiting druggability host spots in protein phosphatase targets
  Dr L Tabernero, Prof D Procter, Dr S Butterworth
Applications accepted all year round
In the past years the use of virtual screening or computer-based screening of compound libraries against selected targets has expanded exponentially the boundaries of drug discovery.
  Non-invasive imaging of the pathophysiology of early systemic sclerosis; fibrosis and oxygenation
  Dr A Murray, Prof G Parker, Prof A Herrick, Dr M Dickinson
Applications accepted all year round
Systemic sclerosis (SSc) is a microvascular autoimmune disease that causes lack of blood flow and scarring and thickening of skin and tissues within internal organs.
  Identification, screening and scale up of enzymes in the Biocatalyst Discovery Metagenomics platform
  Prof N Scrutton, Prof N Turner
Applications accepted all year round
Background – Enzyme engineering strategies, supported by computational and molecular modelling to maximise speed and efficiency, has been shown to be a powerful tool for (semi-) rational design of enzymes.1,2 We will evaluate protein mobility/dynamics, docking/binding of substrates and calculation of free energy barriers for catalysis.
  Genetic and immunological basis of rare primary immunodeficiency diseases
  Dr P Arkwright, Dr T Briggs, Prof T Hussell
Applications accepted all year round
Objective. To understand the genetic and explore the functional immune basis of rare primary immunodeficiency diseases. Background.
  WRDTP ESRC PhD Studentships 2019/20
 . The White Rose Social Sciences Doctoral Training Partnership (WRDTP), accredited by the Economic and Social Research Council in 2016, is a collaboration across the social sciences at the Universities of Leeds, Sheffield, York, Bradford, Sheffield Hallam, Hull, and Manchester Metropolitan.
  A mechanistic understanding of circadian clock-dependent regulation of the secretory pathway
  Prof K E Kadler, Dr Q-J Meng, Dr J Swift
Applications accepted all year round
The protein secretory pathway comprises a series of membranous compartments and transport vesicles that cells use to synthesise, post-translationally modify, and move proteins for delivery to the plasma membrane or for secretion to the extracellular matrix.
  Regulation of gene expression in Drosophila ovarian germline stem cells
  Prof H Ashe, Prof M Ashe
Applications accepted all year round
Drosophila germline stem cells (GSCs) are a premier model for understanding stem cell regulation. Upon division, one GSC daughter remains a stem cell, whereas the other differentiates into a cystoblast (CB).
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