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We have 19 Bioinformatics PhD Projects, Programmes & Scholarships in Manchester

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Biological Sciences

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Manchester  United Kingdom

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Bioinformatics PhD Projects, Programmes & Scholarships in Manchester

We have 19 Bioinformatics PhD Projects, Programmes & Scholarships in Manchester

Identifying critical pathways regulating autoimmunity in immuno-oncology and arthritis patients

Background. Immune checkpoint inhibitors (CPIs) such as BLOCKING antibodies targeting CTLA4 (e.g. ipilimumab) have revolutionised the treatment of metastatic cancers by offering long-term remission, by boosting the immune response. Read more

Using genomic technologies to determine circadian regulation of psoriasis (Sep 25 entry)

Circadian control of inflammation is emerging as an exciting field, with immediate translation potential. Psoriasis represents a model of immune-mediated inflammation in which the pathology is accessible and amenable to serial investigation. Read more

Ecological and evolutionary strain-level dynamics of key pathogens in the cystic fibrosis lung microbiome.

People with cystic fibrosis (pwCF) harbour chronic lung infections caused by a variety of bacterial pathogens. In the CF airway, mucus accumulates in the lungs potentiating the development of a taxonomically diverse lung microbiome. Read more

Defining the role of glycation in extracellular matrix damage in ageing and diabetic skin

In skin, long-lived extracellular matrix (ECM) components in the dermis undergo a form of ageing where damage is accumulated to their protein structures by mechanisms such as glycation, photo-oxidation and protease cleavage, leading to profound changes in tissue architecture and function. Read more

Decoding the epigenetic mechanisms of drug resistance in aggressive breast cancers

Breast cancers pose a major health burden to modern world as being the most common cancer in women. Estrogen receptor (ER), the classical marker of 70% these cancers, is the nuclear receptor important for cancer progression. Read more

Mechanistic analysis of neurodevelopmental disorders caused by mutations in the gene RAC1

RAC1 is a signalling protein that regulates many cellular processes and is essential during embryonic development. We recently discovered a novel genetic disease called RAC1-related neurodevelopmental disorder (RAC1-NDD) that results from mutations in the RAC1 gene. Read more

Investigating the impact of antibiotic dose on the distribution of resistance mutations

The antimicrobial resistance crisis poses one of the biggest threats to healthcare systems globally. Tackling this crisis requires better understanding of the factors that contribute to resistance evolution, especially those that can be altered or manipulated to inform treatment. Read more

Modelling the ecology and evolution of microbial communities

From the human gut to deep-sea sediments, microbial communities – or microbiomes – colonize virtually every habitat on earth. These microbiomes are central to ecosystem functioning and to host health, and therefore it is essential that we understand how and why they change over time. Read more

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