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We have 213 Biological Sciences PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships in Manchester
Biological Sciences PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships in Manchester
We have 213 Biological Sciences PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships in Manchester
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Computation modelling of biological response to radiation at tissue level for Proton Therapy
Proton Beam Therapy (PBT) is a radically new type of radiotherapy that has the potential to improve the precision and targeting of radiotherapy leading to fewer side effects, faster recovery and better outcomes for patients. Read more
Defining the physiological role and regulation of biological methylations
The regulation of gene expression and function operates at multiple levels. Metabolic pathways in the cell generate metabolites that directly affect DNA, RNA and proteins, regulating the expression and function of many genes, often feeding back on the very enzymes that catalysed their synthesis. Read more
Investigation of aortic remodelling in obesity and role of mitochondrial dysfunction
Obesity is a global healthcare and economic burden with currently more than 650 million adults classified as obese (WHO, 2017). Obesity is a common precursor to type 2 diabetes (T2DM), and both are risk factors for developing cardiovascular disease. Read more
Investigating the role of bioactive lipids in skin health
Human skin depends on systemic provision of fatty acids that are important to maintain the integrity of the epidermal barrier as well as to support the associated immune and inflammatory reactions. Read more
Functional dissection of disease associated genetic loci in rheumatoid arthritis
Rheumatoid arthritis (RA) is a common chronic inflammatory disease characterized by inflammation of the joints and has a high socioeconomic burden. Read more
Mechanisms underlying the effects of light and visual stimuli on mood
Light is not only important for vision, light responsiveness extends to fundamental aspects of mood, cognition, and performance. Read more
Cell-biological mechanisms mediating primary cilium mediated interpretation of Shh signalling during vertebrate neuronal differentiation
Newborn neurons undergo extensive morphological changes as they polarise to extend axons. In the developing spinal cord, newborn neurons extend axons towards their targets in response to cues from the surrounding tissues. Read more
Understanding the gene regulatory landscape of embryonic stem cells and cancer cells
Cell identity is ultimately determined through decoding the genome through the action of gene regulatory mechanisms. In particular, sculpting of the chromatin landscape to reveal unique configurations of gene regulatory elements in each cell type is a major driver of cell identity. Read more
Analysing the factors that regulate expression of blood-brain barrier drug transporter proteins
In order to treat diseases associated with the central nervous system (CNS), e.g. cancer, Parkinson’s disease, depression, it is essential for therapeutic drugs to be able to penetrate into the brain. Read more
Transcriptional control of vascular development
Sprouting of new capillaries from pre-existing vessels (angiogenesis) promotes the formation of almost all blood vessels during development, growth and tissue regeneration. Read more
How extracellular matrix components and chemokines are co-ordinated to control immune cell recruitment
Recruitment of immune cells is a critical component of our ability to fight infection from invasive pathogens. However, this process is also central to inflammatory based diseases such as rheumatoid arthritis as well as in a range of cancer pathologies. Read more
A bioinformatics approach to understanding protein solubility tags.
The crowded environment of a cell cytoplasm reveals that proteins and other biological molecules co-exist at high macromolecular concentrations. Many… Read more
Unravelling the role of Lrig2 during neuromuscular development
Motor nerves connect the spinal cord and brain with muscles in our face, arms, legs and internal organs. The motor nerves send signals which tell these muscles to contract. Read more
Lateral hypothalamus as a visual centre controlling arousal, autonomic function and reflex behaviours
In addition to supporting our conscious perception of the world around us, light and visual stimuli exert wide ranging effects on animal physiology and behaviour via hard-wired ‘reflexes’ which range from simple effects of light on sleep, alertness and neuroendocrine function to the avoidance of rapidly approaching objects. Read more
Evolutionary ‘frenemies’? Understanding the molecular mechanisms underpinning the evolution of endosymbiosis
Symbioses are abundant, taxonomically widespread, ecologically important in a wide-range of habitats, economically important in agricultural systems, and consequently underpin the biodiversity and function of both natural and artificial ecosystems. Read more