(WIS) Inhibition of osteoclastogenesis for the prevention of bone wasting in human disease
Prof J Hoyland, Dr J Bella
28 February 2019
Osteoclasts (OCLs) are phagocytic cells that degrade bone as part of its homeostatic regulation. Abnormal activity of OCLs in several pathologies, such as osteoporosis and cancer, results in loss of bone mass, increased risk of fractures, and in an overall increase in significant morbidity and mortality.