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Biotechnology PhD Projects, Programs & Scholarships in Manchester

We have 52 Biotechnology PhD Projects, Programs & Scholarships in Manchester

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  Interplay between the translation of upstream open reading frames and ribosome nascent chain-associated factors to control gene expression in eukaryotic cells
  Dr M Pool, Prof G D Pavitt
Applications accepted all year round

Funding Type

PhD Type

Eukaryotic mRNAs typically contain one open reading frame that is translated into protein. However many mRNAs contain additional upstream ORFs (uORFs) that regulate protein expression by controlling the flow of ribosomes to the main ORF, often by regulated reinitiation.
  Accurate energy evaluation of receptor-ligand interaction
  Prof P Popelier, Dr S De Visser
Applications accepted all year round

Funding Type

PhD Type

Drug design routinely uses existing computational methods to evaluate the interaction energy between receptor (protein) and ligand (drug) in molecular docking.
  A step change in the modelling of enzymatic catalysis
  Prof P Popelier, Dr L Johannissen
Applications accepted all year round

Funding Type

PhD Type

A deep understanding of enzymatic processes requires an atomic-level description, which is often beyond experimental techniques but achievable through synergy with computational chemistry.
  (MRC DTP) Exploiting tumour-promoting paracrine signals in solid cancers to turbocharge genetically redirected T cells
  Dr A Hurlstone, Prof R Edmondson
Application Deadline: 15 November 2019

Funding Type

PhD Type

Adoptive cell therapy (ACT) using tumour infiltrating lymphocytes (TILs) or genetically redirected T cells are some of the most promising approaches to emerge recently for the treatment of metastatic disease.
  (MRC DTP) Early detection of cancer using identification of volatile metabolites
  Dr J-M Schwartz, Prof P Townsend, Prof S Taylor
Application Deadline: 15 November 2019

Funding Type

PhD Type

Cancer is a disease which more than a third of the world population will get in their life. Different types of cancers have different prevalence and mortality rates, and it has been shown that advances in screening and diagnostic tools reduce mortality.
  (MRC DTP) Placental vascular development in pregnancies complicated by diabetes
  Dr J Myers, Dr E Johnstone, Dr P Brownbill, Dr I Chernyaysky
Application Deadline: 15 November 2019

Funding Type

PhD Type

Maternal diabetes (type 1 & 2) complicates 2-3% of pregnancies. Abnormal fetal growth is common in these pregnancies, manifest as both fetal overgrowth (macrosomia) and fetal growth restriction.
  (MRC DTP) Imaging the microvasculature in preeclampsia
  Dr A Murray, Dr Stephanie Worton, Dr E Johnstone, Dr J Myers
Application Deadline: 15 November 2019

Funding Type

PhD Type

Preeclampsia, new onset high blood pressure and protein in the urine in pregnancy, occurs in 3% of pregnancies and is a common cause of maternal and infant illness and death worldwide.
  (MRC DTP) Model-driven optimization of drug therapy and individualisation of healthcare in chronic kidney disease
  Dr A Galetin, Dr Daniel Scotcher
Application Deadline: 15 November 2019

Funding Type

PhD Type

Chronic kidney disease (CKD) is associated with increasing age, as approximately 50% of individuals over 75 years are affected by some degree of kidney disease.
  Understanding cellulose synthesis in plants
  Prof S Turner, Prof S High
Applications accepted all year round

Funding Type

PhD Type

It is clear that there is now enormous pressure to develop much better replacements for plastics derived from fossil fuels. One possibility is to develop novel plastics based on polymers from plants.
  The chemical glycobiology of carbohydrate metabolism
  Prof R Field, Prof S Flitsch
Applications accepted all year round

Funding Type

PhD Type

Carbohydrates are widespread in nature and fulfil many important biological functions. However, the biology of carbohydrates is much less well explored than that of nucleic acids and proteins.
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