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Biotechnology PhD Projects, Programs & Scholarships in Manchester

We have 42 Biotechnology PhD Projects, Programs & Scholarships in Manchester

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  Engineering synthetic ribosomal RNAs (rRNAs) in yeast
  Prof P Cai, Prof D Delneri
Application Deadline: 31 July 2020

Funding Type

PhD Type

Advances in DNA synthesis technology have led to rapid growth in the field of synthetic biology, heralding a nascent era of synthetic genomics.
  Robust Bioprocess Design and Engineering for Novel Biosurfactant Production
  Dr J Winterburn
Application Deadline: 28 October 2020

Funding Type

PhD Type

Biosurfactants are naturally occurring amphiphiles with a range of unique properties including biodegradability and tolerance of a wide range of temperature and pH.
  Nanoparticle conjugates for agricultural disease detection and diagnosis
  Dr L Wong, Prof J Micklefield
Applications accepted all year round

Funding Type

PhD Type

Infectious diseases in plant crops present a significant socioeconomic burden globally, as they compromise the safety and reliability of food supply, as well as other agricultural products.
  The chemical glycobiology of carbohydrate metabolism
  Prof R Field, Prof S Flitsch
Applications accepted all year round

Funding Type

PhD Type

Carbohydrates are widespread in nature and fulfil many important biological functions. However, the biology of carbohydrates is much less well explored than that of nucleic acids and proteins.
  Tackling antibiotic resistance: developing a vaccine against gonorrhoea
  Prof J P Derrick, Dr F Hayes
Applications accepted all year round

Funding Type

PhD Type

Gonorrhoea is caused by the Gram-negative bacterium Neisseria gonorrhoeae and is a serious public health problem in developing and developed countries.
  Non-invasive imaging of the pathophysiology of early systemic sclerosis; fibrosis and oxygenation
  Dr A Murray, Prof G Parker, Prof A Herrick, Dr M Dickinson
Applications accepted all year round

Funding Type

PhD Type

Systemic sclerosis (SSc) is a microvascular autoimmune disease that causes lack of blood flow and scarring and thickening of skin and tissues within internal organs.
  Partitioning primary and secondary changes of gene expression caused by gene mutations
  Dr D Talavera, Prof G D Pavitt, Dr J-M Schwartz
Applications accepted all year round

Funding Type

PhD Type

Control of gene expression is a complex cell process, which involves balancing both the synthesis and the degradation of RNA and protein so as to establish optimal levels of each protein.
  Development of a three dimensional in vitro model of the human cornea to dissect the inflammatory events associated with sight-threatening ocular pathogens
  Dr C Dobson, Dr C Maldonado-Codina, Prof P Morgan
Applications accepted all year round

Funding Type

PhD Type

The presence of microbes at the corneal surface may trigger low grade discomfort through to acute eye infection and permanent loss of vision.
  Tackling neurovascular dysfunction in dementia: a cell biology and biomaterials approach
  Prof N Hooper, Dr M Domingos, Dr T Wang
Applications accepted all year round

Funding Type

PhD Type

Neurovascular dysfunction is a central process in the pathogenesis of Alzheimer’s disease and other dementias. In the brain, vascular and neuronal structures are tightly integrated forming the multicellular neurovascular unit comprising endothelial cells, pericytes, astrocytes, microglia and neurons.
  Understanding regulation of gene expression during development via an integrated computational analysis of ‘omics data
  Prof S Hubbard, Prof S Griffiths-Jones, Dr M Baron
Applications accepted all year round

Funding Type

PhD Type

Embryonic development requires exquisite control of the expression of large numbers of genes, integrating components from the genome, transcriptome and proteome.
  Development of robust and effective downstream purification and analytical techniques for glycolipid biosurfactants
  Research Group: Molecular Systems and Biomaterials
  Dr J Winterburn
Application Deadline: 1 June 2020

Funding Type

PhD Type

Glycolipid biosurfactants are naturally occurring, microbially produced amphiphiles with a range of unique properties including biodegradability and tolerance of a wide range of temperature and pH.
  EPSRC CDT in Science and Applications of Graphene and Related Nanomaterials (Graphene NOWANO)

Funding Type

PhD Type

Established in 2013 with EPSRC funding and now supported by the University of Manchester and industry, Graphene NOWNANO CDT offers PhD training in science, technology and applications of the fast-growing family of two-dimensional materials.
  In vitro assessment of drug sequestration into lysosomes and in silico prediction of implications for drug disposition and therapeutic efficacy
  Dr A Galetin, Dr D Hallifax
Applications accepted all year round

Funding Type

PhD Type

Intracellular concentration of a drug is an important determinant of its efficacy, toxicity, and potential drug-drug interactions [1].
  Interplay between the translation of upstream open reading frames and ribosome nascent chain-associated factors to control gene expression in eukaryotic cells
  Dr M Pool, Prof G D Pavitt
Applications accepted all year round

Funding Type

PhD Type

Eukaryotic mRNAs typically contain one open reading frame that is translated into protein. However many mRNAs contain additional upstream ORFs (uORFs) that regulate protein expression by controlling the flow of ribosomes to the main ORF, often by regulated reinitiation.
  Accurate energy evaluation of receptor-ligand interaction
  Prof P Popelier, Dr S De Visser
Applications accepted all year round

Funding Type

PhD Type

Drug design routinely uses existing computational methods to evaluate the interaction energy between receptor (protein) and ligand (drug) in molecular docking.
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