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We have 26 Cancer Biology PhD Projects, Programmes & Scholarships for Self-funded Students in Manchester
Cancer Biology PhD Projects, Programmes & Scholarships for Self-funded Students in Manchester
We have 26 Cancer Biology PhD Projects, Programmes & Scholarships for Self-funded Students in Manchester
The role of nuclear localisation of adhesion proteins in tumour growth and invasion
Overview. This project seeks to understand how tumour growth and invasion are controlled by the localisation of certain proteins in cancer cells. Read more
(MB-PhD) Smaller, Better, Faster, Stronger: real-time colorectal cancer management using nanopore sequencing.
Colorectal cancer (CRC) is ranking among the leading causes of cancer-related morbidity and mortality and where early onset is increasing. Read more
(MB-PhD) Investigation of signalling from the microenvironment in metastasis of invasive lobular breast cancer
This project focuses on lobular breast cancer (LBC), a less-studied subtype of breast cancer constituting about 15% of diagnoses. Read more
On-Demand Regulation of the Transcriptional Activity of Redox Induced Transcription Factors in Cancer Using Bioelectronics
Cancer heterogeneity reduces the effectiveness of many cancer therapies. Therefore, the most promising treatments are those that inhibit several signalling pathways crucial for cancer survival. Read more
Development and Characterization of Hydrogel-Based Model(s) for Pancreatic Cancer
Pancreatic Ductal Adenocarcinoma (PDAC), which develops from cells lining pancreas ducts, represents 95% of all pancreatic cancer cases. Read more
(RadNet Non-Clinical PhD)Development of in vitro and in silico models to predict impact of intermittent flow on hypoxic gene expression
The presence of regions of hypoxia is well established as a key factor of tumour progression and therapy resistance, in particular radiotherapy (RT). Read more
(BBSRC NWD) Harnessing organic catalysts for precision interaction mapping in ubiquitin-like systems
This PhD project focuses on the development and application of innovative tools to achieve high-resolution mapping of protein-protein interactions (PPIs) within ubiquitin-like protein (UBL) systems, addressing a critical gap in understanding cellular signalling. Read more
Decoding the epigenetic mechanisms of drug resistance in aggressive breast cancers
Breast cancers pose a major health burden to modern world as being the most common cancer in women. Estrogen receptor (ER), the classical marker of 70% these cancers, is the nuclear receptor important for cancer progression. Read more
Evaluation of Tripterygium wilfordii derived compounds as novel treatments for medulloblastoma.
Medulloblastoma is the most common paediatric malignant brain tumour, accounting for 20% of childhood brain tumours cases per annum in the United Kingdom alone, with approximately one-third of patients dying from the disease worldwide. Read more
Defining the molecular mechanisms of leukaemia chemotherapies
Chemotherapies are usually the backbone of cancer treatment for either curative or palliative patient care. Multiple therapies can be used for the same disease, with the choice of drug dependent on parameters such as the patient’s age and fitness. Read more
Towards controlling cell-state switching of neural crest differentiation states in melanoma evolution
Melanoma, a deadly skin cancer, exhibits remarkable adaptability, enabling metastasis, therapy resistance, and immune evasion. Central to this adaptability is the ability of melanoma cells to transition between distinct functional states, a process rooted in mechanisms of cell fate choice. Read more
(BBSRC NWD) Investigating the mechanism of cell signalling by cytonemes in Drosophila ovarian germline stem cells
Cell signalling is essential to multicellular life and its misregulation causes a vast number of human diseases, including cancer and cardiovascular disorders. … Read more
Comparative investigations into proton and photon radiation in chromosomal instability- and telomere spectrum disorders
Chromosomal instability- and telomere spectrum disorders (CITSDs), such as Bloom syndrome (BS), Fanconi anaemia (FA), or Dyskeratosis Congenita (DKC) are inherited conditions with congenital and developmental abnormalities and impaired ability to maintain chromosomal integrity. Read more
(MB-PhD)Immunomodulation in multiple myeloma
Multiple myeloma is a devastating B-cell malignancy for which there is no cure. The development of immunomodulatory drugs (IMiDs) has proved transformative to multiple myeloma care, however, their remain unanswered questions related to the mechanism of action of this important drug class. Read more
(MB-PhD) Multiomic investigation of drug resistance in lobular breast cancers
Lobular breast cancers represent one of the understudied cancers but of unmet need, due to their poor response to targeted therapies. Read more
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