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Cancer / Oncology PhD Projects, Programs & Scholarships in Manchester

We have 27 Cancer / Oncology PhD Projects, Programs & Scholarships in Manchester

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Showing 1 to 10 of 27
  Design, Synthesis and Biological Evaluation of novel inhibitors of the JAK-STAT signalling pathway with potential application as immune oncology agents
  Dr R Whitehead, Dr K Finegan, Prof N Turner
Applications accepted all year round
Small molecule inhibitors of the JAK-STAT signalling pathway often possess interesting biological properties with many displaying potent anti-proliferative activity towards cancer cell lines.
  Role of cutaneous circadian clocks in gating skin repair
  Dr Q-J Meng, Dr M Sherratt
Application Deadline: 31 March 2019
Biological clocks play a key role by temporally controlling the function of whole organisms (including humans) and individual tissues and cells to be aligned with the rhythmic environment.
  Characterizing the heterogeneity of stem cells in the normal breast and breast tumours
  Dr A Ucar, Prof K R Brennan
Applications accepted all year round
Tissue-restricted stem cells are crucial in supporting the development and maintenance of normal tissues. This is also true for tumours, as only a small population of tumour cells, which are known as cancer stem cells, have the unique stemness features and tumour-initiating capacity.
  (MCRC Non-Clinical) NK cell control of tumour growth dependent on the inflammatory environment
  Prof D Davis, Dr S Zelenay
Application Deadline: 24 February 2019
Arguably, immune therapies for cancer are at a tipping point. Undoubtedly, there are many more successes to come. Understanding the mechanisms behind a strong anti-tumour immune response will surely seed new ideas for immune therapies.
  (MCRC Non-Clinical) Assessing the impact of oxygen tension on the generation of cancer immunity
  Dr J Honeychurch, Prof J O'Connor, Prof K Williams
Application Deadline: 24 February 2019
The importance of T-cell immunity to cancer outcome is increasingly recognised. Infiltration of tumours by T-cells correlates with patient survival, and immunotherapies designed to enhance T cell function, such as checkpoint blockade, have revolutionised the way in which many solid malignancies are treated.
  (WIS) The application of novel Top down Mass Spectrometry to uncover targeted mutagenesis of DNA repair proteins for exposomics
  Dr A Povey, Prof P Barran, Prof G Margison
Application Deadline: 28 February 2019
Next generation sequencing of human tumour DNA consistently shows large numbers of mutations scattered throughout the genome (e.g.
  Analysis of the role of microRNAs in the regulation of NF-kappaB dynamics and function
  Prof M White, Dr A P Gilmore
Applications accepted all year round
NF-κB is one of most important cell signalling systems in the body and controls inflammation and cell fate. NF-κB signalling involves complex dynamics involving oscillations of the NF-κB complex between the nucleus and cytoplasm in activated cells.
  Developing Blood Cell Production Platforms for Therapeutic Applications
  Prof G Lacaud, Prof A J Dickson
Applications accepted all year round
Generation and modification of blood cells ex vivo or in vitro harbours a huge potential in cell based therapies and regenerative medicine.
  How an IFNγ target gene mediates resistance to immunotherapy
  Dr A Hurlstone, Prof K Williams, Dr J Bruce
Applications accepted all year round
Metastatic melanoma, a highly aggressive form of skin cancer, can respond well to immunotherapy with immune checkpoint inhibitors, but there are still a significant proportion of patients not benefitting or for whom benefits are not durable.
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