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Cell Biology / Development PhD Projects, Programs & Scholarships in Manchester

We have 74 Cell Biology / Development PhD Projects, Programs & Scholarships in Manchester

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Showing 1 to 10 of 74
  (MRC DTP) Exploring the transcriptomic and chromatin landscapes of fibroblast-like synoviocytes in rheumatoid arthritis
  Dr S Eyre, Mr P Martin, Prof A Morris
Application Deadline: 15 November 2019

Funding Type

PhD Type

Genetic studies in rheumatoid arthritis (RA) have been successful in identifying regions of the genome which contribute to disease risk, but it is often unclear which genes they effect.
  (MRC DTP) Using super-resolution microscopy to understand immune cell inhibitory receptors and develop novel immune therapies
  Prof D Davis, Dr J Honeychurch
Application Deadline: 15 November 2019

Funding Type

PhD Type

Super-resolution microscopy allows us to study immune cell activity in unprecedented detail. Recently, Davis’s research team has used these microscopes to study the changing arrangements of molecules on the surface of immune cells as they survey other cells for signs of disease.
  (MRC DTP) The role of the lung microenvironment in regulating metastatic colonisation by breast cancer
  Dr R Clarke, Dr Ciara O'Brien, Dr R Eyre
Application Deadline: 15 November 2019

Funding Type

PhD Type

The metastatic spread of breast cancer cells and their colonisation of important organs such as the lungs is the cause of death in 95% of breast cancer.
  (MRC DTP) Design of allosteric small molecule inhibitors of fibrosis using advanced molecular simulation techniques
  Dr R A Bryce, Dr K Piper Hanley, Dr R Whitehead
Application Deadline: 15 November 2019

Funding Type

PhD Type

Integrins are a family of protein receptors that play a major role in cell survival, growth and migration. Their function is to transmit signals across the cell membrane by undergoing an elegant large scale structural rearrangement.
  (MRC DTP) Understanding the regulation of an IL-1alpha inflammatory reaction
  Dr D Brough, Prof S Allan, Dr J Rivers-Auty
Application Deadline: 15 November 2019

Funding Type

PhD Type

Background. Inflammation is a response of the innate immune system that controls infection and promotes resistance and tissue repair.
  (MRC DTP) Decoding the role of vascular smooth muscle cell heterogeneity in cardiovascular disease by single cell genomics
  Prof N Bobola, Prof N Hanley
Application Deadline: 15 November 2019

Funding Type

PhD Type

Cardiovascular disease is the leading cause of death worldwide. Vascular smooth muscle cells (VSMC) are implicated in the pathogenesis of several types of vascular diseases, such as aneurysm, atherosclerosis, vascular calcification and congenital vascular disease.
  Cutting off the fuel supply to calcium pumps in pancreatic cancer: a novel therapeutic strategy
  Dr J Bruce, Prof K Williams, Dr A P Gilmore
Applications accepted all year round

Funding Type

PhD Type

Background and Rationale. Pancreatic ductal adenocarcinoma (PDAC) has the poorest survival and limited treatment options. Therefore, the search for novel therapeutic targets and drugs designed to selectively kill PDAC cells must remain a central research strategy.
  Determining how immune responses are regulated at mucosal surfaces
  Dr M Travis, Prof D Thornton
Applications accepted all year round

Funding Type

PhD Type

The immune system must be primed to quickly respond to infection, but must also be tightly regulated so it ignores harmless substances and our own tissues.
  Development of a three dimensional in vitro model of the human cornea to dissect the inflammatory events associated with sight-threatening ocular pathogens
  Dr C Dobson, Dr C Maldonado-Codina, Prof P Morgan
Applications accepted all year round

Funding Type

PhD Type

The presence of microbes at the corneal surface may trigger low grade discomfort through to acute eye infection and permanent loss of vision.
  Understanding regulation of gene expression during development via an integrated computational analysis of ‘omics data
  Prof S Hubbard, Prof S Griffiths-Jones, Dr M Baron
Applications accepted all year round

Funding Type

PhD Type

Embryonic development requires exquisite control of the expression of large numbers of genes, integrating components from the genome, transcriptome and proteome.
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