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Cell Biology / Development PhD Projects, Programs & Scholarships in Manchester

We have 69 Cell Biology / Development PhD Projects, Programs & Scholarships in Manchester

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Manchester  United Kingdom

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We have 69 Cell Biology / Development PhD Projects, Programs & Scholarships in Manchester

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CRISPR manipulation of gene expression in retinal organoids to model and rescue human disease

Human pluripotent stem cells can be used in the lab to grow 3D retinal structures called retinal organoids. This allows us to investigate both the early and later events of human eye development and disease. Read more

The functions of the Class II Pi3-kinase signals in vivo

Phosphoinositide lipids (PIPs) play critical roles in development and the homeostasis of adult tissues and their dysfunction has been linked to major human diseases such as cancer, diabetes, myopathies and neuropathies. Read more

Mechanistic analysis of neurodevelopmental disorders caused by mutations in the gene RAC1

RAC1 is a signalling protein that regulates many cellular processes and is essential during embryonic development. We recently discovered a novel genetic disease called RAC1-related neurodevelopmental disorder (RRND) that results from mutations in the RAC1 gene. Read more

Insights into eye disease: understanding the molecular basis of age-related macular degeneration

Dysregulation of innate immunity has been implicated as playing a key role in the development of age-related macular degeneration (AMD) – a major form of blindness in the industrialised world (see [1-5]). Read more

Investigating the role of bioactive lipids in skin health

Human skin depends on systemic provision of fatty acids that are important to maintain the integrity of the epidermal barrier as well as to support the associated immune and inflammatory reactions. Read more

Understanding the role of spliceosome gene mutations in disease

The DNA of a cell is copied into a pre-messenger RNA (pre-mRNA) that the cell uses as a template for protein production. Some of the information contained in DNA is not required for making proteins, therefore, unwanted information must be removed before a protein is made. Read more

Do Altered host-microbial interactions promote oral inflammation during ageing?

As we age, the systems of our bodies become less able to function; rendering people increasingly infirm. Ageing affects our immune system, impeding our ability to both fight infection and maintain tolerance. Read more

A mechanistic understanding of circadian clock-dependent regulation of the secretory pathway

The protein secretory pathway comprises a series of membranous compartments and transport vesicles that cells use to synthesise, post-translationally modify, and move proteins for delivery to the plasma membrane or for secretion to the extracellular matrix. Read more

Transcriptional control of vascular development

Sprouting of new capillaries from pre-existing vessels (angiogenesis) promotes the formation of almost all blood vessels during development, growth and tissue regeneration. Read more

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