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Genetics PhD Projects, Programs & Scholarships in Manchester

We have 33 Genetics PhD Projects, Programs & Scholarships in Manchester

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  (WIS) How food-borne Listeria monocytogenes overcomes the host defence mechanisms at the single cell level?
  Dr P Paszek, Prof I Roberts
Application Deadline: 28 February 2019
Pathogens have developed intricate ways to overcome the host’s immune system. In this proposal we will study the direct interaction of macrophages with the important food-borne bacterial pathogen Listeria monocytogenes that causes significant human morbidity and mortality.
  (WIS) Determining the role of vascularisation in glomerular development
  Prof R Lennon, Dr R Naylor
Application Deadline: 28 February 2019
The kidney has an essential role in filtering waste and toxins from the blood. When kidney function declines the impact on health is severe.
  Understanding the role of spliceosome gene mutations in disease
  Dr R O'Keefe, Prof B Newman
Applications accepted all year round
The DNA of a cell is copied into a pre-messenger RNA (pre-mRNA) that the cell uses as a template for protein production. Some of the information contained in DNA is not required for making proteins, therefore, unwanted information must be removed before a protein is made.
  Genetic mechanisms of chronic kidney disease
  Prof M Tomaszewski, Prof A Woolf
Applications accepted all year round
Chronic kidney disease (CKD) is one of the most common complex disorders. The prevalence of CKD is on the rise in all populations around the globe and both the clinical and economic pressures of CKD on the healthcare systems increase exponentially.
  Metals and host-pathogen interactions: the role of metal handling systems in the human gastrointestinal pathogen Campylobacter jejuni
  Dr J Cavet, Dr D Linton
Applications accepted all year round
Campylobacter jejuni is a globally important food-borne pathogen causing an estimated 400-500 million cases of acute human gastroenteritis each year.
  Genetic and immunological basis of rare primary immunodeficiency diseases
  Dr P Arkwright, Dr T Briggs, Prof T Hussell
Applications accepted all year round
Objective. To understand the genetic and explore the functional immune basis of rare primary immunodeficiency diseases. Background.
  Developing Blood Cell Production Platforms for Therapeutic Applications
  Prof G Lacaud, Prof A J Dickson
Applications accepted all year round
Generation and modification of blood cells ex vivo or in vitro harbours a huge potential in cell based therapies and regenerative medicine.
  Interplay between the translation of upstream open reading frames and ribosome nascent chain-associated factors to control gene expression in eukaryotic cells
  Dr M Pool, Prof G D Pavitt
Applications accepted all year round
Eukaryotic mRNAs typically contain one open reading frame that is translated into protein. However many mRNAs contain additional upstream ORFs (uORFs) that regulate protein expression by controlling the flow of ribosomes to the main ORF, often by regulated reinitiation.
  Regulation of gene expression in Drosophila ovarian germline stem cells
  Prof H Ashe, Prof M Ashe
Applications accepted all year round
Drosophila germline stem cells (GSCs) are a premier model for understanding stem cell regulation. Upon division, one GSC daughter remains a stem cell, whereas the other differentiates into a cystoblast (CB).
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