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Genetics PhD Projects, Programs & Scholarships in Manchester

We have 47 Genetics PhD Projects, Programs & Scholarships in Manchester

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Manchester  United Kingdom

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We have 47 Genetics PhD Projects, Programs & Scholarships in Manchester

Deciphering a novel anti-ageing epigenetic programme

Over two decades of intense research in the field of epigenetics have produced compelling evidence that chromatin modifications are crucial for processes such as DNA repair, transcription, splicing, mitosis, meiosis, and in the preservation of the epigenetic memory of cells. Read more

Bacterial genome evolution

The University of Manchester’s KNH Centre for Biomedical Egyptology (https://sites.manchester.ac.uk/knhcentre/) is offering a unique self-funded PhD studentship in Bacterial genome evolution through the study of ancient omics. Read more

Understanding the role of spliceosome gene mutations in disease

The DNA of a cell is copied into a pre-messenger RNA (pre-mRNA) that the cell uses as a template for protein production. Some of the information contained in DNA is not required for making proteins, therefore, unwanted information must be removed before a protein is made. Read more

The role of Myh10 (Non-Muscle Myosin IIB) in epicardial-myocardial cross talk during coronary vessel development.

During cardiac development the coronary vessels form from the epicardium, which is the outer epithelial cell layer of the heart. Formation of the coronary vasculature is a critical event in cardiac development, since the vasculature is required to nourish the cardiac muscle and maintain cardiac function throughout life. Read more

Interplay between the translation of upstream open reading frames and ribosome nascent chain-associated factors to control gene expression in eukaryotic cells

Eukaryotic mRNAs typically contain one open reading frame that is translated into protein. However many mRNAs contain additional upstream ORFs (uORFs) that regulate protein expression by controlling the flow of ribosomes to the main ORF, often by regulated reinitiation. Read more

An omics approach to understand and treat KMT2C-related neurodevelopmental disorder using induced pluripotent stem cells and CRISPR-Cas9

Background. We recently identified a novel human syndrome caused by mutations in a gene called KMT2C1. Patients with this condition predominantly have developmental delay and intellectual disability indicating the important function of this gene in brain’s normal development and function. Read more

The role of the spliceosome protein Prpf8 in embryonic development

Errors that occur during cardiac development cause congenital heart defects (CHD). Despite the prevalence of CHD, the developmental processes that ensure the heart forms correctly are still being elucidated. Read more

Development and Evolution of Shapes: Investigating the genetic pathways governing the leaf shape in Arabidopsis

The shapes and sizes of organisms and organs are scrupulously conserved within a species. What regulates the shapes and sizes of organisms and their lateral organs are intriguing and fundamental questions in Biology. Read more

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