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Genetics PhD Projects, Programs & Scholarships in Manchester

We have 31 Genetics PhD Projects, Programs & Scholarships in Manchester

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  Engineering synthetic ribosomal RNAs (rRNAs) in yeast
  Prof P Cai, Prof D Delneri
Application Deadline: 31 July 2020

Funding Type

PhD Type

Advances in DNA synthesis technology have led to rapid growth in the field of synthetic biology, heralding a nascent era of synthetic genomics.
  Generation of universal donor transplant tissue by genomic engineering of induced pluripotent stem cells
  Dr F Manson, Dr T Wang
Applications accepted all year round

Funding Type

PhD Type

Project Description. Blindness can be caused by mutations in genes expressed in the retinal pigment epithelium (RPE), the tissue adjacent to the rod and cone photoreceptor cells that is essential for their normal function.
  Bayesian statistical approaches to identification of shared genetic signals
  Dr H Guo, Prof C Berzuini
Applications accepted all year round

Funding Type

PhD Type

Project description. A number of genes have been found associated with health conditions of interest (e.g. autoimmune disease) from multiple studies.
  Improved classification of myositis disease subtypes using statistical genetics approaches for stratified medicine
  Dr J Lamb, Dr AM Morris, Dr H Chinoy
Applications accepted all year round

Funding Type

PhD Type

Keywords. idiopathic inflammatory myopathy, myositis, genetics, disease classification, stratified medicine. Idiopathic inflammatory myopathies (IIM) are heterogeneous autoimmune diseases characterized by inflammation of skeletal muscle (myositis).
  Expanding the Genetic Code of a Synthetic Yeast
  Prof P Cai, Dr A Green
Applications accepted all year round

Funding Type

PhD Type

The proposed project aims to develop an efficient yeast-based protein expression platform with an expanded genetic code. The standard genetic code of natural organisms comprises 20 canonical amino acids.
  Metals and host-pathogen interactions: the role of metal handling systems in the human gastrointestinal pathogen Campylobacter jejuni
  Dr J Cavet, Dr D Linton
Applications accepted all year round

Funding Type

PhD Type

Campylobacter jejuni is a globally important food-borne pathogen causing an estimated 400-500 million cases of acute human gastroenteritis each year.
  Genetic mechanisms of chronic kidney disease
  Prof M Tomaszewski, Prof A Woolf
Applications accepted all year round

Funding Type

PhD Type

Chronic kidney disease (CKD) is one of the most common complex disorders. The prevalence of CKD is on the rise in all populations around the globe and both the clinical and economic pressures of CKD on the healthcare systems increase exponentially.
  Understanding regulation of gene expression during development via an integrated computational analysis of ‘omics data
  Prof S Hubbard, Prof S Griffiths-Jones, Dr M Baron
Applications accepted all year round

Funding Type

PhD Type

Embryonic development requires exquisite control of the expression of large numbers of genes, integrating components from the genome, transcriptome and proteome.
  The role of the spliceosome protein Prpf8 in embryonic development
  Dr K Hentges
Applications accepted all year round

Funding Type

PhD Type

Errors that occur during cardiac development cause congenital heart defects (CHD). Despite the prevalence of CHD, the developmental processes that ensure the heart forms correctly are still being elucidated.
  Interplay between the translation of upstream open reading frames and ribosome nascent chain-associated factors to control gene expression in eukaryotic cells
  Dr M Pool, Prof G D Pavitt
Applications accepted all year round

Funding Type

PhD Type

Eukaryotic mRNAs typically contain one open reading frame that is translated into protein. However many mRNAs contain additional upstream ORFs (uORFs) that regulate protein expression by controlling the flow of ribosomes to the main ORF, often by regulated reinitiation.
  Deciphering a novel anti-ageing epigenetic programme
  Dr G Poulin, Prof A Sharrocks
Applications accepted all year round

Funding Type

PhD Type

Over two decades of intense research in the field of epigenetics have produced compelling evidence that chromatin modifications are crucial for processes such as DNA repair, transcription, splicing, mitosis, meiosis, and in the preservation of the epigenetic memory of cells.
  Understanding disease mechanisms in autoimmune inflammatory muscle disease
  Dr J Lamb, Dr H Chinoy
Applications accepted all year round

Funding Type

PhD Type

The idiopathic inflammatory myopathies are a spectrum of rare autoimmune disorders characterized by inflammation of muscle tissue (myositis), which leads to muscle weakness and fatigue, and heterogeneous systemic organ involvement.
  Cellular protein quality control in diabetes-associated heart disease: The insight into mechanisms and therapeutic potentials
  Dr V Liu, Dr L Swanton
Applications accepted all year round

Funding Type

PhD Type

Cardiovascular complications are the leading causes of diabetes mortality. With the exception of vascular and valvular injuries, diabetic cardiomyopathy (DCM) is a distinct myocardial disease, which is characterised by abnormal cellular metabolism and defects in organelles function, leading to impaired cardiac function.
  Regulation of gene expression in Drosophila ovarian germline stem cells
  Prof H Ashe, Prof M Ashe
Applications accepted all year round

Funding Type

PhD Type

Drosophila germline stem cells (GSCs) are a premier model for understanding stem cell regulation. Upon division, one GSC daughter remains a stem cell, whereas the other differentiates into a cystoblast (CB).
  Understanding the functional role of the non-coding genome in cardiovascular disease
  Prof N Bobola, Prof N Hanley
Applications accepted all year round

Funding Type

PhD Type

Cardiovascular disease is the leading cause of death worldwide. Inherited DNA sequence variants contribute to human diseases and susceptibility.
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