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We have 17 Genomics PhD Projects, Programmes & Scholarships in Manchester
Genomics PhD Projects, Programmes & Scholarships in Manchester
We have 17 Genomics PhD Projects, Programmes & Scholarships in Manchester
VariantCurator: A “spell-checker” for genomic variant data that will improve diagnostic rates by improving the accuracy of genetic data in clinical literature and increasing the findability of data in historic literature
Rare diseases affect <1-in-2,000 people, but ~8,000 rare genetic diseases impact ~10% of births globally. These arise from variations in patients’ DNA sequences. Read more
VariantVisualiser: Ensuring precise diagnoses of genetic disorders through the development of intuitive software that facilitates the integration and visualisation of complex informatics with biological and clinical data
Rare diseases affect. This proposal builds on substantial efforts of a Human Genome Organization committee which has proposed a unified professional-standard for representing genomic data which, when finalised, will be adopted world-wide. Read more
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(UoM - A* STAR) Engineering modular human artificial chromosomes
Rapid advances in DNA synthesis techniques have made it possible to chemically synthesize and modify viruses, biochemical pathways, and bacterial genomes. Read more
Unravelling complex somatic genomic variations: advancing early diagnostics and precision medicine
Complex somatic structural variations (SVs) in genomic regions such as centromeres and telomeres play a crucial role in driving many genetic disorders. Read more
Identifying critical pathways regulating autoimmunity in immuno-oncology and arthritis patients
Background. Immune checkpoint inhibitors (CPIs) such as BLOCKING antibodies targeting CTLA4 (e.g. ipilimumab) have revolutionised the treatment of metastatic cancers by offering long-term remission, by boosting the immune response. Read more
Genetic and acoustic diversity in an invasive parrot
The ring-necked parakeet Psittacula krameri is one of the world’s most successfully introduced species. Native to the Indian sub-continent and sub-Saharan Africa, this species is the UK’s only naturalised parrot, and populations are continuing to increase rapidly across Europe. Read more
A novel role in mitochondrial homeostasis for the anti-ageing factor RBBP5
The mitochondrion has evolved from the endosymbiotic interaction of an alpha-proteobacterium and an archaeon. One major event during this evolution was the transferring of genes from the symbiont to the host. Read more
Understanding antimicrobial resistance mechanisms and transmission ability via their genetic associations
The ability of bacteria to become resistance to antimicrobials is one of the biggest threats of our age. Read more
Mutations in anaerobic mixed communities
The majority of the human gut microbiome is comprised of anaerobic commensal microbes. Anaerobic commensals are involved in immune responses, absorption of nutrients, drug metabolism, they can protect us against pathogens (1) and can spread antibiotic resistance genes or generate resistance via de novo mutations (2). Read more
Mechanistic analysis of neurodevelopmental disorders caused by mutations in the gene RAC1
RAC1 is a signalling protein that regulates many cellular processes and is essential during embryonic development. We recently discovered a novel genetic disease called RAC1-related neurodevelopmental disorder (RAC1-NDD) that results from mutations in the RAC1 gene. Read more
Modelling the ecology and evolution of microbial communities
From the human gut to deep-sea sediments, microbial communities – or microbiomes – colonize virtually every habitat on earth. These microbiomes are central to ecosystem functioning and to host health, and therefore it is essential that we understand how and why they change over time. Read more
Circadian clock control of adipocyte metabolism
Obesity is a major public health issue affecting one third of UK adults, and an estimated 2.1 billion individuals worldwide. The role of circadian clock dysfunction in the development of obesity is becoming clear, with disruptive lifestyles (e.g. Read more
Investigate the novel therapeutic potential for treating heart failure in diabetes.
Heart failure is the most common cause of mortality in diabetes patients, but current diabetes therapies have a limited impact on the incidence of heart failure in diabetic populations. Read more
Molecular pathogenesis and treatment of obesity/diabetes-associated heart disease: The insight into mechanisms and therapeutic potentials
Both the number of cases and the prevalence of obesity/diabetes are increasing globally. Cardiovascular complications are the leading causes of diabetes mortality. Read more
Understanding the evolution of gene regulatory networks through biophysical modelling and machine learning
The ability to coordinate the expression of genes within a cell is at the heart of life. When and how much of a specific gene is turned into a protein is essential for organisms to respond to their environment and to manage resources. Read more
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