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Immunology PhD Projects, Programs & Scholarships in Manchester

We have 28 Immunology PhD Projects, Programs & Scholarships in Manchester

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Showing 1 to 15 of 28
  Characterising B cells in Rheumatoid Arthritis: Their role in susceptibility, pathogenesis, and treatment response
  Dr S Viatte, Dr D Plant, Dr Q-J Meng, Prof A Barton
Applications accepted all year round

Funding Type

PhD Type

Note. Dr D Plant is the main supervisor for this project. Background. Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that primarily affects the joints.
  Improved classification of myositis disease subtypes using statistical genetics approaches for stratified medicine
  Dr J Lamb, Dr AM Morris, Dr H Chinoy
Applications accepted all year round

Funding Type

PhD Type

Keywords. idiopathic inflammatory myopathy, myositis, genetics, disease classification, stratified medicine. Idiopathic inflammatory myopathies (IIM) are heterogeneous autoimmune diseases characterized by inflammation of skeletal muscle (myositis).
  Tackling antibiotic resistance: developing a vaccine against gonorrhoea
  Prof J P Derrick, Dr F Hayes
Applications accepted all year round

Funding Type

PhD Type

Gonorrhoea is caused by the Gram-negative bacterium Neisseria gonorrhoeae and is a serious public health problem in developing and developed countries.
  Metals and host-pathogen interactions: the role of metal handling systems in the human gastrointestinal pathogen Campylobacter jejuni
  Dr J Cavet, Dr D Linton
Applications accepted all year round

Funding Type

PhD Type

Campylobacter jejuni is a globally important food-borne pathogen causing an estimated 400-500 million cases of acute human gastroenteritis each year.
  Development of a three dimensional in vitro model of the human cornea to dissect the inflammatory events associated with sight-threatening ocular pathogens
  Dr C Dobson, Dr C Maldonado-Codina, Prof P Morgan
Applications accepted all year round

Funding Type

PhD Type

The presence of microbes at the corneal surface may trigger low grade discomfort through to acute eye infection and permanent loss of vision.
  Do Altered host-microbial interactions promote oral inflammation during ageing?
  Dr J Konkel, Prof A McBain
Applications accepted all year round

Funding Type

PhD Type

As we age, the systems of our bodies become less able to function; rendering people increasingly infirm. Ageing affects our immune system, impeding our ability to both fight infection and maintain tolerance.
  Environmental control of dendritic cell activation and function during pulmonary type 2 inflammation
  Prof A MacDonald, Prof J Allen
Applications accepted all year round

Funding Type

PhD Type

Type 2 inflammation is a defining feature of infection with parasitic worms (helminths), as well as being responsible for widespread suffering in allergies.
  The respiratory metagenome during exacerbations of asthma
  Prof N Papadopoulos, Prof D Robertson, Dr S Megremis
Applications accepted all year round

Funding Type

PhD Type

Asthma is an international pandemic, with 10% or more of the global population having experience asthma symptoms some time in life.
  Immune phenotyping of refractory rheumatoid arthritis disease
  Prof Maya Buch, Dr S Viatte
Applications accepted all year round

Funding Type

PhD Type

Treatment of rheumatoid arthritis (RA) has been transformed with the introduction of targeted therapies twenty years ago (comprising biologic disease modifying anti-rheumatic drugs, bDMARDS; and the more recent small molecule JAK inhibitors).
  Determining how immune responses are regulated at mucosal surfaces
  Prof M Travis, Prof D Thornton
Applications accepted all year round

Funding Type

PhD Type

The immune system must be primed to quickly respond to infection, but must also be tightly regulated so it ignores harmless substances and our own tissues.
  Exploiting tumour-promoting paracrine signals in solid cancers to turbocharge genetically redirected T cells
  Dr A Hurlstone, Prof R Edmondson
Applications accepted all year round

Funding Type

PhD Type

Adoptive cell therapy (ACT) using tumour infiltrating lymphocytes (TILs) or genetically redirected T cells are some of the most promising approaches to emerge recently for the treatment of metastatic disease.
  Understanding disease mechanisms in autoimmune inflammatory muscle disease
  Dr J Lamb, Dr H Chinoy
Applications accepted all year round

Funding Type

PhD Type

The idiopathic inflammatory myopathies are a spectrum of rare autoimmune disorders characterized by inflammation of muscle tissue (myositis), which leads to muscle weakness and fatigue, and heterogeneous systemic organ involvement.
  Building the human endometrium in vitro: The role of macrophages in receptive and decidual endometrium to optimise reproductive health
  Dr E Mann, Dr Peter Ruane, Prof J Aplin, Dr L Mohiyiddeen
Applications accepted all year round

Funding Type

PhD Type

The human endometrium is a highly dynamic tissue that rapidly generates over ~20 days and differentiates to form a uterus lining receptive to embryo implantation, further transforming into decidua to support embryonic development, or breaking down before regenerating a few days later.
  Predicting treatment response in juvenile idiopathic arthritis using a single cell genomics based approach
  Prof W Thomson, Dr S Smith, Mr P Martin, Prof A Morris
Applications accepted all year round

Funding Type

PhD Type

Background. Juvenile idiopathic arthritis (JIA) is a group of chronic arthropathies of unknown cause which can result in long-term disability and poor quality of life for children and can continue well into adult life.
  The impact of zinc deficiency on Alzheimer’s disease
  Dr C Lawrence, Prof D Brough
Applications accepted all year round

Funding Type

PhD Type

In addition to memory problems, people with Alzheimer’s disease (AD) also experience ‘non-memory’ behavioural symptoms including depression, anxiety, and agitation.
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