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Immunology PhD Projects, Programs & Scholarships in Manchester

We have 30 Immunology PhD Projects, Programs & Scholarships in Manchester

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  Virus pathogenesis: interplay between the unfolded protein response and innate immunity.
  Dr S-W Chan, Prof R Ford
Applications accepted all year round
The unfolded protein response (UPR) is a cellular homeostatic response in restoring endoplasmic reticulum balance upon stress conditions e.g.
  Deciphering Aspergillus fumigatus - Pseudomonas aeruginosa synergistic interactions in coinfection
  Dr J Amich, Prof E Bignell, Dr S Fowler
Applications accepted all year round
Pathogen-pathogen interactions in polymicrobial infections are known to directly impact, often to worsen, disease outcomes. Aspergillus fumigatus is the most common fungal pathogen and Pseudomonas aeruginosa one of the most prevalent bacterial pathogens of the human lung.
  Hair follicle dysbiosis and immune privilege alteration as drivers of human skin dysfunction, interrogating dandruff pathogenesis as a model
  Prof R Paus, Dr J Hardman
Application Deadline: 15 April 2019
Despite the psycho-social burden of dandruff and the commercial relevance of its management, the molecular and cellular pathobiology of this condition is poorly understood.
  A state-of-the-art effector trap to identify secreted effectors of tissue invasion in the major fungal pathogen of human lungs
  Prof E Bignell, Dr J Amich, Dr A Reid
Applications accepted all year round
The often-fatal fungal lung disease invasive aspergillosis (IA) has claimed more than 8 million human lives since its emergence ~ 40 years ago.
  Investigating the role of Inter-alpha-inhibitor Heavy Chain 3 in age-related macular degeneration
  Dr S Clark, Prof T Day
Application Deadline: 31 March 2019
Age-related macular degeneration (AMD) is one of the leading causes of blindness globally. It is well established that although a multifactorial disease, AMD is largely genetically driven, with the majority of attributable genetic risk being associated with loci on chromosome 1 (Chr1) and chromosome 10 (Chr10).
  The role of CD4+ T-cells specific for GRP78 in the pathogenesis of rheumatoid arthritis (RA)
  Dr S Viatte, Prof A Barton, Mr P Martin
Application Deadline: 31 March 2019
Background. Rheumatoid arthritis (RA) is a complex autoimmune disease of unknown aetiology. Our understanding of mechanisms underlying the cause of the disease is still very limited, which prevents the development of efficient treatment strategies.
  Functional investigation of genetic variants associated with rheumatoid arthritis using CRISPR-Cas9
  Dr G Orozco, Dr S Eyre
Application Deadline: 31 March 2019
The aim of this PhD project is to characterise gene regulatory elements (enhancers) harbouring rheumatoid arthritis (RA) associated variants, in order to determine the genes, biological pathways and mechanisms by which these variants act in specific cell subtypes to increase the risk of disease.
  Metals and host-pathogen interactions: the role of metal handling systems in the human gastrointestinal pathogen Campylobacter jejuni
  Dr J Cavet, Dr D Linton
Applications accepted all year round
Campylobacter jejuni is a globally important food-borne pathogen causing an estimated 400-500 million cases of acute human gastroenteritis each year.
  Analysis of the role of microRNAs in the regulation of NF-kappaB dynamics and function
  Prof M White, Dr A P Gilmore
Applications accepted all year round
NF-κB is one of most important cell signalling systems in the body and controls inflammation and cell fate. NF-κB signalling involves complex dynamics involving oscillations of the NF-κB complex between the nucleus and cytoplasm in activated cells.
  Genetic and immunological basis of rare primary immunodeficiency diseases
  Dr P Arkwright, Dr T Briggs, Prof T Hussell
Applications accepted all year round
Objective. To understand the genetic and explore the functional immune basis of rare primary immunodeficiency diseases. Background.
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