Pathogen-pathogen interactions in polymicrobial infections are known to directly impact, often to worsen, disease outcomes. Aspergillus fumigatus is the most common fungal pathogen and Pseudomonas aeruginosa one of the most prevalent bacterial pathogens of the human lung.
Age-related macular degeneration (AMD) is one of the leading causes of blindness globally. It is well established that although a multifactorial disease, AMD is largely genetically driven, with the majority of attributable genetic risk being associated with loci on chromosome 1 (Chr1) and chromosome 10 (Chr10).
Background. Rheumatoid arthritis (RA) is a complex autoimmune disease of unknown aetiology. Our understanding of mechanisms underlying the cause of the disease is still very limited, which prevents the development of efficient treatment strategies.
The aim of this PhD project is to characterise gene regulatory elements (enhancers) harbouring rheumatoid arthritis (RA) associated variants, in order to determine the genes, biological pathways and mechanisms by which these variants act in specific cell subtypes to increase the risk of disease.
NF-κB is one of most important cell signalling systems in the body and controls inflammation and cell fate. NF-κB signalling involves complex dynamics involving oscillations of the NF-κB complex between the nucleus and cytoplasm in activated cells.