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Medicine PhD Projects, Programmes & Scholarships in Manchester

We have 124 Medicine PhD Projects, Programmes & Scholarships in Manchester

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Discipline

Medicine

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Location

Manchester  United Kingdom

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We have 124 Medicine PhD Projects, Programmes & Scholarships in Manchester

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Mechanistic analysis of neurodevelopmental disorders caused by mutations in the gene RAC1

RAC1 is a signalling protein that regulates many cellular processes and is essential during embryonic development. We recently discovered a novel genetic disease called RAC1-related neurodevelopmental disorder (RRND) that results from mutations in the RAC1 gene. Read more

Epigenetic regulation in heart failure and cardiac sudden death

A large proportion of heart failure patients die from cardiac sudden death (SCD), a direct result of lethal ventricular arrhythmias, which is the principal cause of mortality from heart disease worldwide and remains a major unresolved public health problem. Read more

Investigation of aortic remodelling in obesity and role of mitochondrial dysfunction

Obesity is a global healthcare and economic burden with currently more than 650 million adults classified as obese (WHO, 2017). Obesity is a common precursor to type 2 diabetes (T2DM), and both are risk factors for developing cardiovascular disease. Read more

Tackling antibiotic seeking in behaviour in veterinary and dental practices

Antimicrobial resistance is a global health and patient safety emergency driven by the unnecessary use of antimicrobial drugs. Dentistry is responsible for around 10% of antibiotics globally, with up to 80% unnecessary of inappropriate use. Read more

Immune phenotyping of refractory rheumatoid arthritis disease

Treatment of rheumatoid arthritis (RA) has been transformed with the introduction of targeted therapies twenty years ago (comprising biologic disease modifying anti-rheumatic drugs, bDMARDS; and the more recent small molecule JAK inhibitors). Read more

Detecting subtle but clinically significant cognitive change in an ageing population

A major challenge facing dementia research is identifying the earliest indicators of clinically-significant cognitive decline. This research project will be linked to the newly established Memory Assessment & Cognitive Ageing Research Unit (MACARU), led by the primary supervisor. Read more

Enhanced variant interpretation for the discovery of mechanisms underpinning Ophthalmic genomic disorders

This project will utilize large genomic sequencing datasets from the 100,000 genomes project and the UK BioBank to understand how genomic variation impacts the development and function of cells vital for correct vision. Read more

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